LORATIN

1. Introduction

Loratin is a brand name for loratadine, a second-generation antihistamine used to treat allergic conditions. Unlike older antihistamines, it causes minimal drowsiness, making it suitable for daytime use.

2. Description

• Generic Name: Loratadine

• Brand Names: Loratin (common in some markets), Claritin (global brand)

• Dosage Forms:

  • Tablets (10 mg)

  • Syrup (5 mg/5 ml)

  • Disintegrating tablets

• Manufacturer: Various pharmaceutical companies

3. Uses

✔ Allergic rhinitis (seasonal and perennial) ✔ Chronic urticaria (hives) ✔ Allergic conjunctivitis ✔ Other allergic skin reactions

4. Mechanism of Action

• Selective H1-receptor antagonist

• Blocks histamine action without crossing blood-brain barrier significantly

• Provides 24-hour relief with single daily dose

5. Side Effects

Common (rare and mild):

• Headache

• Dry mouth

• Fatigue (uncommon)

• Mild gastrointestinal discomfort

Serious (very rare):

• Tachycardia

• Allergic reactions (rash, swelling)

• Liver dysfunction (with prolonged high doses)

6. Storage

• Store at room temperature (15-30°C)

• Protect from moisture and light

• Keep out of reach of children

7. Precautions & Warnings

⚠ Liver impairment: Dose adjustment may be needed ⚠ Pregnancy: Category B – use only if clearly needed ⚠ Breastfeeding: Small amounts excreted in milk ⚠ Drug Interactions:

• Erythromycin, ketoconazole (may increase loratadine levels)

• CNS depressants (minimal interaction)

8. Dosage

• Adults & children >12 years: 10 mg once daily

• Children 2-12 years:

  • 30 kg: 10 mg daily

  • ≤30 kg: 5 mg daily

• Elderly: No adjustment typically needed

9. Special Considerations

• Can be taken with or without food

• Onset of action within 1-3 hours

• Maximum effect at 8-12 hours

• Safe for long-term use under medical supervision

10. Conclusion

Loratin (loratadine) is a safe, effective, non-sedating antihistamine for managing various allergic conditions. Its once-daily dosing and minimal side effects make it a preferred choice for allergy relief.