SUDOPEN 500 GM

Antibacterial

Description
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SUDOPEN 500 MG is a sterile, lyophilized powder for intravenous (IV) or intramuscular (IM) administration, combining Cefoperazone (3rd-generation cephalosporin) and Sulbactam (beta-lactamase inhibitor). It is effective against multidrug-resistant Gram-negative and some Gram-positive infections.

Composition

Active Ingredients per vial:
- Cefoperazone Sodium (equivalent to 500 mg Cefoperazone).
- Sulbactam Sodium (equivalent to 500 mg Sulbactam).
Excipients: Sodium carbonate (for pH adjustment).

Mechanism of Action

Cefoperazone:
- Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
- Broad-spectrum activity against Gram-negative (Pseudomonas, Enterobacteriaceae) and some Gram-positive bacteria.
Sulbactam:
- Irreversibly inhibits beta-lactamase enzymes, enhancing Cefoperazone’s efficacy against resistant strains.

Dosage & Administration

Standard Adult Dose:

1–2 g (1:1 ratio) every 12 hours (IV/IM).
Severe Infections: Up to 2 g every 8 hours (max 8 g/day).

Pediatric Dose (≥1 year):

40–80 mg/kg/day (divided every 6–12 hours).

Renal/Hepatic Dose Adjustment:

Renal Impairment (CrCl <30 mL/min): Reduce dose by 50%.
Hepatic Dysfunction: Monitor closely (Cefoperazone is bile-excreted).

Administration:

IV: Reconstitute with 2–5 mL sterile water, then dilute in 50–100 mL NS/D5W; infuse over 30–60 minutes.
IM: Deep injection (use lidocaine for pain relief).

Uses (Indications)

✔ Intra-abdominal infections (with metronidazole for anaerobes). ✔ Respiratory tract infections (pneumonia, bronchitis). ✔ Skin/soft tissue infections. ✔ UTIs and gynecological infections. ✔ Septicemia.

Storage

Unreconstituted powder: Store below 25°C; protect from light/moisture.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze.

Recommendations

✔ Monitor CBC, liver/renal function during prolonged therapy. ✔ Not effective against MRSA or Enterococci. ✔ Avoid alcohol (disulfiram-like reaction possible).

Important Note

Contraindications:

Hypersensitivity to cephalosporins/penicillins.
History of severe allergic reactions to beta-lactams.

Side Effects:

Common: Diarrhea, rash, elevated liver enzymes.
Serious:
- Bleeding (vitamin K-dependent coagulopathy).
- C. difficile colitis.

Drug Interactions:

Anticoagulants: ↑ Bleeding risk (monitor PT/INR).
Alcohol: Disulfiram-like reaction (flushing, tachycardia).

Pregnancy & Lactation:

Category B (use if benefits outweigh risks).
Breastfeeding: Low excretion in milk (caution advised).

Presentation

Single-dose vial (500 mg + 500 mg powder for reconstitution).

Composition

Active Ingredients per vial:
- Cefoperazone Sodium (equivalent to 500 mg Cefoperazone).
- Sulbactam Sodium (equivalent to 500 mg Sulbactam).
Excipients: Sodium carbonate (for pH adjustment).

Mechanism of Action

Cefoperazone:
- Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
- Broad-spectrum activity against Gram-negative (Pseudomonas, Enterobacteriaceae) and some Gram-positive bacteria.
Sulbactam:
- Irreversibly inhibits beta-lactamase enzymes, enhancing Cefoperazone’s efficacy against resistant strains.

Dosage & Administration

Standard Adult Dose:

1–2 g (1:1 ratio) every 12 hours (IV/IM).
Severe Infections: Up to 2 g every 8 hours (max 8 g/day).

Pediatric Dose (≥1 year):

40–80 mg/kg/day (divided every 6–12 hours).

Renal/Hepatic Dose Adjustment:

Renal Impairment (CrCl <30 mL/min): Reduce dose by 50%.
Hepatic Dysfunction: Monitor closely (Cefoperazone is bile-excreted).

Administration:

IV: Reconstitute with 2–5 mL sterile water, then dilute in 50–100 mL NS/D5W; infuse over 30–60 minutes.
IM: Deep injection (use lidocaine for pain relief).

Uses (Indications)

✔ Intra-abdominal infections (with metronidazole for anaerobes).
✔ Respiratory tract infections (pneumonia, bronchitis).
✔ Skin/soft tissue infections.
✔ UTIs and gynecological infections.
✔ Septicemia.

Storage

Unreconstituted powder: Store below 25°C; protect from light/moisture.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze.

Recommendations

✔ Monitor CBC, liver/renal function during prolonged therapy.
✔ Not effective against MRSA or Enterococci.
✔ Avoid alcohol (disulfiram-like reaction possible).

Important Note

Contraindications:

Hypersensitivity to cephalosporins/penicillins.
History of severe allergic reactions to beta-lactams.

Side Effects:

Common: Diarrhea, rash, elevated liver enzymes.
Serious:
- Bleeding (vitamin K-dependent coagulopathy).
- C. difficile colitis.

Drug Interactions:

Anticoagulants: ↑ Bleeding risk (monitor PT/INR).
Alcohol: Disulfiram-like reaction (flushing, tachycardia).

Pregnancy & Lactation:

Category B (use if benefits outweigh risks).
Breastfeeding: Low excretion in milk (caution advised).

Presentation

Single-dose vial (500 mg + 500 mg powder for reconstitution).

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Composition

Active Ingredients per vial:
- Cefoperazone Sodium (equivalent to 500 mg Cefoperazone).
- Sulbactam Sodium (equivalent to 500 mg Sulbactam).
Excipients: Sodium carbonate (for pH adjustment).

Mechanism of Action

Cefoperazone:
- Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
- Broad-spectrum activity against Gram-negative (Pseudomonas, Enterobacteriaceae) and some Gram-positive bacteria.
Sulbactam:
- Irreversibly inhibits beta-lactamase enzymes, enhancing Cefoperazone’s efficacy against resistant strains.

Dosage & Administration

Standard Adult Dose:

1–2 g (1:1 ratio) every 12 hours (IV/IM).
Severe Infections: Up to 2 g every 8 hours (max 8 g/day).

Pediatric Dose (≥1 year):

40–80 mg/kg/day (divided every 6–12 hours).

Renal/Hepatic Dose Adjustment:

Renal Impairment (CrCl <30 mL/min): Reduce dose by 50%.
Hepatic Dysfunction: Monitor closely (Cefoperazone is bile-excreted).

Administration:

IV: Reconstitute with 2–5 mL sterile water, then dilute in 50–100 mL NS/D5W; infuse over 30–60 minutes.
IM: Deep injection (use lidocaine for pain relief).

Uses (Indications)

✔ Intra-abdominal infections (with metronidazole for anaerobes).
✔ Respiratory tract infections (pneumonia, bronchitis).
✔ Skin/soft tissue infections.
✔ UTIs and gynecological infections.
✔ Septicemia.

Storage

Unreconstituted powder: Store below 25°C; protect from light/moisture.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze.

Recommendations

✔ Monitor CBC, liver/renal function during prolonged therapy.
✔ Not effective against MRSA or Enterococci.
✔ Avoid alcohol (disulfiram-like reaction possible).

Important Note

Contraindications:

Hypersensitivity to cephalosporins/penicillins.
History of severe allergic reactions to beta-lactams.

Side Effects:

Common: Diarrhea, rash, elevated liver enzymes.
Serious:
- Bleeding (vitamin K-dependent coagulopathy).
- C. difficile colitis.

Drug Interactions:

Anticoagulants: ↑ Bleeding risk (monitor PT/INR).
Alcohol: Disulfiram-like reaction (flushing, tachycardia).

Pregnancy & Lactation:

Category B (use if benefits outweigh risks).
Breastfeeding: Low excretion in milk (caution advised).

Presentation

Single-dose vial (500 mg + 500 mg powder for reconstitution).

Reviews

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Be the first to review “SUDOPEN 500 GM”

Description
Reviews (0)

Composition

Active Ingredients per vial:
- Cefoperazone Sodium (equivalent to 500 mg Cefoperazone).
- Sulbactam Sodium (equivalent to 500 mg Sulbactam).
Excipients: Sodium carbonate (for pH adjustment).

Mechanism of Action

Cefoperazone:
- Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
- Broad-spectrum activity against Gram-negative (Pseudomonas, Enterobacteriaceae) and some Gram-positive bacteria.
Sulbactam:
- Irreversibly inhibits beta-lactamase enzymes, enhancing Cefoperazone’s efficacy against resistant strains.

Dosage & Administration

Standard Adult Dose:

1–2 g (1:1 ratio) every 12 hours (IV/IM).
Severe Infections: Up to 2 g every 8 hours (max 8 g/day).

Pediatric Dose (≥1 year):

40–80 mg/kg/day (divided every 6–12 hours).

Renal/Hepatic Dose Adjustment:

Renal Impairment (CrCl <30 mL/min): Reduce dose by 50%.
Hepatic Dysfunction: Monitor closely (Cefoperazone is bile-excreted).

Administration:

IV: Reconstitute with 2–5 mL sterile water, then dilute in 50–100 mL NS/D5W; infuse over 30–60 minutes.
IM: Deep injection (use lidocaine for pain relief).

Uses (Indications)

✔ Intra-abdominal infections (with metronidazole for anaerobes).
✔ Respiratory tract infections (pneumonia, bronchitis).
✔ Skin/soft tissue infections.
✔ UTIs and gynecological infections.
✔ Septicemia.

Storage

Unreconstituted powder: Store below 25°C; protect from light/moisture.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze.

Recommendations

✔ Monitor CBC, liver/renal function during prolonged therapy.
✔ Not effective against MRSA or Enterococci.
✔ Avoid alcohol (disulfiram-like reaction possible).

Important Note

Contraindications:

Hypersensitivity to cephalosporins/penicillins.
History of severe allergic reactions to beta-lactams.

Side Effects:

Common: Diarrhea, rash, elevated liver enzymes.
Serious:
- Bleeding (vitamin K-dependent coagulopathy).
- C. difficile colitis.

Drug Interactions:

Anticoagulants: ↑ Bleeding risk (monitor PT/INR).
Alcohol: Disulfiram-like reaction (flushing, tachycardia).

Pregnancy & Lactation:

Category B (use if benefits outweigh risks).
Breastfeeding: Low excretion in milk (caution advised).

Presentation

Single-dose vial (500 mg + 500 mg powder for reconstitution).

Reviews

There are no reviews yet.

Be the first to review “SUDOPEN 500 GM”

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