1. Product Description
Brand Name:Ā Fabiflu 400mg
Generic Name:Ā Favipiravir
Manufacturer:Ā Glenmark Pharmaceuticals (India)
Dosage Form:Ā Film-coated tablets
Packaging:Ā Blister strips (varies by pack size)
Approval Status:Ā Emergency use authorization for COVID-19 in India
2. Composition
Component | Details |
---|---|
Active Ingredient | Favipiravir 400mg |
Inactive Ingredients | Microcrystalline cellulose, Povidone, Croscarmellose sodium, Magnesium stearate, Film coating agents |
3. Therapeutic Uses
Primary Indication:
-
Treatment ofĀ mild to moderate COVID-19Ā in adults (as per emergency approvals)
Mechanism of Action:
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InhibitsĀ RNA-dependent RNA polymerase (RdRp), blocking viral replication of SARS-CoV-2 and other RNA viruses.
Recommended For:
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Patients withĀ SpOā ā„ 94%Ā (not for severe/critical COVID-19)
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Early-stage infection (within 3-5 days of symptom onset)
4. Dosage & Administration
Standard COVID-19 Treatment Course:
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Day 1 (Loading Dose):Ā 1800mgĀ (4.5 tablets of 400mg)Ā twice daily
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Days 2-10 (Maintenance):Ā 800mgĀ (2 tablets of 400mg)Ā twice daily
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Total Duration:Ā 10-14 days (or as prescribed)
Administration Guidelines:
ā Swallow whole with water (do not crush/chew)
ā Can be takenĀ with or without food
ā MaintainĀ consistent 12-hour intervalsĀ between doses
5. Contraindications
āĀ PregnancyĀ (teratogenic risk ā causes fetal abnormalities)
āĀ Severe liver/kidney impairment
āĀ History of gout or hyperuricemiaĀ (may increase uric acid)
āĀ HypersensitivityĀ to favipiravir
6. Side Effects
Common | Less Common | Serious (Seek Medical Help) |
---|---|---|
Nausea | Diarrhea | Severe liver damage (jaundice) |
Headache | Elevated uric acid | Allergic reactions (rash, swelling) |
Stomach pain | Increased ALT/AST (LFT abnormalities) | Neuropsychiatric symptoms (hallucinations) |
7. Storage Conditions
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Temperature: Below 30°C
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Humidity:Ā Keep in a dry place
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Packaging:Ā Retain in original blister strips until use
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Shelf Life:Ā Typically 24 months (check packaging)
Disposal:
-
Do not flush. Return unused tablets to pharmacies for safe disposal.
8. Drug Interactions
ā Ā Pyrazinamide/Theophylline:Ā May alter drug levels
ā Ā Repaglinide:Ā Potential hypoglycemia risk
ā Ā Alcohol:Ā May worsen liver effects
9. Special Precautions
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Pregnancy Test RequiredĀ before prescribing to women of childbearing age.
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Contraception MandatoryĀ during andĀ 1 week post-treatment.
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Monitoring Needed:
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Liver function tests (LFTs)
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Uric acid levels
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Clinical symptom progression
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10. Manufacturer & Regulatory Notes
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Approved Under:Ā Emergency use in India, Russia, Japan (as Avigan)
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Not FDA-ApprovedĀ for COVID-19 in the USA
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Prescription-OnlyĀ ā Self-medication is unsafe.
Key Takeaways
-
Fabiflu 400mg is anĀ antiviralĀ for early COVID-19 management.
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StrictlyĀ avoid in pregnancyĀ (risk category: X).
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Early initiation (within 72 hours of symptoms) improves outcomes.
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