Fludarabine is a chemotherapy medication used to treat certain types of cancer, including chronic lymphocytic leukemia (CLL), indolent non-Hodgkin’s lymphoma (NHL), and follicular lymphoma.
Composition:
Each 10 mg tablet of Fludarabine 10 mg contains fludarabine phosphate, a synthetic analog of the nucleoside arabinoside.
Mechanism of Action: Fludarabine works by inhibiting the production of DNA, which is necessary for cell growth and division. It also damages the DNA of cancer cells, leading to cell death.
Use: Fludarabine is used to treat:
- Chronic lymphocytic leukemia (CLL)
- Indolent non-Hodgkin’s lymphoma (NHL)
- Follicular lymphoma
- Hairy cell leukemia
Dosage: The recommended dosage of Fludarabine varies depending on the patient’s condition and the treatment regimen. Typical dosages range from 25 mg/m² to 30 mg/m² every 28 days.
Side Effects: Common side effects of Fludarabine include:
- Nausea and vomiting
- Fatigue
- Diarrhea
- Abdominal pain
- Headache
- Dizziness
- Confusion
- Weakness
- Hair loss
- Infection
Recommendation: Fludarabine should be administered under the guidance of an experienced healthcare provider. Patients should be monitored for signs of infection, including fever, chills, and sore throat. Patients should also be advised to report any changes in their vision or hearing to their healthcare provider.
Important Note:
- Fludarabine can cause severe bone marrow suppression, which can lead to infections, bleeding, and anemia.
- Patients with a history of bone marrow disorders or who are taking medications that suppress the bone marrow should be cautious when using Fludarabine.
- Women of childbearing potential should avoid pregnancy during treatment with Fludarabine due to the risk of fetal harm.
- Patients with pre-existing liver or kidney disease should be monitored closely during treatment with Fludarabine.
It’s important to note that this information is intended to serve as a general overview of Fludarabine and its uses, and should not be considered a substitute for medical advice from a qualified healthcare provider.
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