FOLICULIN 150Ā is aĀ recombinant FSH (rFSH) injectionĀ used inĀ fertility treatmentsĀ to stimulateĀ ovarian follicle developmentĀ in women andĀ sperm productionĀ in men with hypogonadotropic hypogonadism.
Composition
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Active Ingredient:Ā Follitropin alfa/beta 150 IUĀ (recombinant human FSH).
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Form: Lyophilized powder or prefilled pen (with solvent for reconstitution).
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Purity:Ā Highly purifiedĀ (no LH activity, minimal proteins).
Mechanism of Action
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Directly stimulates ovarian folliclesĀ (in women).
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Supports spermatogenesisĀ (in men with low FSH).
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Used in ART (IVF/IUI) & ovulation induction.
Dosage & Administration
For Women
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Ovulation Induction (OI):Ā 75ā150 IU/day SC/IMĀ (adjust per response).
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IVF/ICSI:Ā 150ā450 IU/dayĀ (based on ovarian reserve).
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Duration: 7ā14 days (until follicles reachĀ 17ā20 mm).
For Men
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150ā300 IU 2ā3x/weekĀ (with hCG) for spermatogenesis.
Reconstitution
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Mix powder with provided solvent.
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InjectĀ subcutaneously (preferred) or IM.
Indications
ā
Ā Anovulation (PCOS, hypothalamic origin).
ā
Ā Assisted Reproductive Technology (IVF/IUI).
ā
Ā Male infertility (hypogonadotropic hypogonadism).
Storage & Stability
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Unopened vials/pens:Ā 2ā8°CĀ (do not freeze).
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After reconstitution: Use immediately (discard unused portions).
Key Recommendations
āĀ Monitor with ultrasound & estradiol levelsĀ (prevent OHSS).
āĀ Start low in PCOSĀ (high OHSS risk).
āĀ Rotate injection sitesĀ (avoid lipoatrophy).
Important Safety Notes
ā Ā Ovarian Hyperstimulation Syndrome (OHSS) RiskĀ ā Requires close monitoring.
ā Ā Multiple Pregnancy RiskĀ ā Higher with fertility drugs.
ā Ā Contraindications:
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Ovarian/testicular tumors
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Pregnancy
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Uncontrolled thyroid disease
Comparison with Other FSH Preparations
Feature | FOLICULIN 150 (rFSH) | hMG (Menopur) | Clomiphene Citrate |
---|---|---|---|
Hormone | Pure FSH | FSH + LH | Oral anti-estrogen |
Purity | Recombinant (no LH) | Urinary-derived | N/A |
Male Use | Yes | Yes | No |
Cost | High | Moderate | Low |
Conclusion
FOLICULIN 150Ā is aĀ high-purity rFSHĀ forĀ ovulation induction & ART, offeringĀ better consistencyĀ than urinary FSH.
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