Furmecil 15mg

Furmecil (Gimeracil, Oteracil, and Tegafur) 15mg Tablet is a medication used to treat certain types of cancer. Here are some key points about the product:

Composition:

Furmecil 15mg Tablet contains three active ingredients:

1. Gimeracil (5.8mg): a dihydropyrimidine dehydrogenase (DPD) inhibitor
2. Oteracil (15.8mg): an antiviral agent that inhibits the replication of certain viruses
3. Tegafur (20mg): a pyrimidine derivative that is converted to 5-fluorouracil (5-FU) in the body, which is a chemotherapy agent

Indications:

Furmecil 15mg Tablet is indicated for the treatment of:

1. Gastric cancer
2. Gastroesophageal junction (GEJ) cancer
3. Esophageal cancer

Mechanism of Action:

The combination of Gimeracil, Oteracil, and Tegafur works by:

1. Inhibiting the activity of DPD, which is an enzyme involved in the metabolism of 5-FU
2. Reducing the conversion of Tegafur to 5-FU, thereby increasing the levels of active 5-FU in the body
3. Inhibiting the replication of certain viruses, such as herpes simplex virus and varicella-zoster virus

Dosage and Administration:

The recommended dosage of Furmecil 15mg Tablet is:

• 1 tablet taken orally twice daily, with or without food
• Take at the same time each day

Side Effects:

Common side effects of Furmecil 15mg Tablet include:

1. Diarrhea
2. Stomatitis (mouth sores)
3. Fatigue
4. Nausea
5. Vomiting
6. Abdominal pain

Serious side effects can include:

1. Leukopenia (low white blood cell count)
2. Neutropenia (low neutrophil count)
3. Thrombocytopenia (low platelet count)
4. Hepatotoxicity (e.g., liver damage)

Contraindications:

Furmecil 15mg Tablet is contraindicated in patients with:

1. Hypersensitivity to any of the active ingredients
2. Severe hepatic impairment (Child-Pugh C)
3. Pregnancy or breastfeeding

Precautions:

1. Patients with a history of liver disease or liver damage should be closely monitored while receiving Furmecil 15mg Tablet.
2. Patients with a history of hematological disorders or blood dyscrasias should be closely monitored while receiving Furmecil 15mg Tablet.

Patient Counseling:

• Patients should be counseled on the importance of taking their medication as directed and not missing doses.
• Patients should be instructed to report any signs of diarrhea, stomatitis, or abdominal pain.
• Patients should be advised to report any changes in their appetite or weight loss.

Storage and Handling:

• Store bottles at room temperature between 15°C and 30°C (59°F and 86°F).
• Do not expose to direct sunlight or moisture.
• Use within 24 hours of opening.

Please note that the dosage and administration information is based on the recommended dosage and may vary depending on individual patient needs and circumstances.