Cabozantinib 60mg (Cabometyx)
Product Description: Cabozantinib is a prescription medicine used to treat:
- Advanced renal cell carcinoma (kidney cancer)
- Locally advanced or metastatic medullary thyroid cancer (thyroid cancer)
Composition: Cabozantinib is a tyrosine kinase inhibitor, which means it works by inhibiting the activity of certain enzymes that help cancer cells grow.
Mechanism of Action: Cabozantinib inhibits the activity of several tyrosine kinases, including:
- VEGFR2 (vascular endothelial growth factor receptor 2)
- VEGFR3 (vascular endothelial growth factor receptor 3)
- RET (rearranged during transfection) protein
- MET (hepatocyte growth factor receptor) protein
By inhibiting these kinases, cabozantinib:
- Reduces angiogenesis (the formation of new blood vessels that feed tumors)
- Inhibits tumor cell growth and proliferation
- Induces apoptosis (cell death) in cancer cells
Dosage: The recommended dose of cabozantinib is 60mg taken orally once daily, with or without food.
Uses: Cabozantinib is approved for the treatment of:
- Advanced renal cell carcinoma (kidney cancer)
- Locally advanced or metastatic medullary thyroid cancer (thyroid cancer)
Side Effects: Common side effects of cabozantinib include:
- Fatigue
- Diarrhea
- Nausea
- Decreased appetite
- Weight loss
- Hair loss
- Skin reactions (e.g., rash, itching)
- Abdominal pain
- Headache
- Blood clotting disorders
Recommendation: Cabozantinib should be prescribed by a healthcare professional experienced in the treatment of cancer.
Important Note:
- Cabozantinib can cause serious side effects, including:
- Gastrointestinal perforation (tearing of the stomach or intestine)
- Hepatotoxicity (liver damage)
- Embryofetal toxicity (harm to the developing fetus)
- Patients with a history of gastrointestinal perforation or fistula should not receive cabozantinib.
- Women who are pregnant or breastfeeding should not take cabozantinib.
- Men who are taking cabozantinib should use effective contraception to avoid fathering a child.
It’s essential to discuss any concerns or questions with your healthcare provider before starting cabozantinib therapy.
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