Biodronate 90mg

Biodronate (Pamidronate) 90mg Intravenous is a prescription medication used to treat osteoporosis, a condition characterized by brittle and porous bones that can lead to fractures.

Composition:

Each vial of Biodronate contains 90mg of pamidronate, a bisphosphonate that inhibits the activity of osteoclasts, the cells responsible for breaking down bone tissue.

Mechanism of Action:

Pamidronate works by:

• Inhibiting the activity of osteoclasts, which reduces bone resorption and increases bone density
• Suppressing the formation of new bone by inhibiting the activity of osteoblasts, the cells responsible for forming new bone tissue
• Reducing the levels of calcium in the blood by inhibiting the absorption of calcium in the gut

Indications:

Biodronate is indicated for the treatment of:

• Osteoporosis in postmenopausal women who are at high risk of fracture
• Osteoporosis in men who are at high risk of fracture
• Hypercalcemia (elevated levels of calcium in the blood) due to malignancy or other conditions

Administration:

Biodronate is administered intravenously over a period of approximately 2 hours. The recommended dose is 90mg every 2 weeks.

Side Effects:

Common side effects of Biodronate include:

• Nausea
• Vomiting
• Abdominal pain
• Diarrhea
• Headache
• Dizziness

Rare but serious side effects include:

• Osteonecrosis (death of bone tissue) of the jaw or femur
• Atypical subtrochanteric or diaphyseal femoral fractures (breaks in the thigh bone)
• Hypocalcemia (low levels of calcium in the blood)

Contraindications:

Biodronate is contraindicated in patients with:

• Hypocalcemia (low levels of calcium in the blood)
• Hypercalcemia (elevated levels of calcium in the blood)
• History of severe allergic reactions to pamidronate or other components of the product
• Pregnancy or breastfeeding

Precautions:

Patients with a history of dental problems or other oral health issues should be monitored closely while using Biodronate. Patients with a history of kidney disease or severe kidney impairment should be monitored closely for changes in their kidney function.

Interactions:

Biodronate may interact with other medications, including:

• Bisphosphonates
• Corticosteroids
• Hormone replacement therapy (HRT)
• Thyroid hormone replacement therapy

Important Note:

Biodronate should be administered by a healthcare professional in a clinical setting. Patients should be monitored regularly for changes in their bone density, as well as for signs of allergic reactions or other adverse events.