Actamase

Antibacterial

Description
Shipping Options
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Actamase is a combination injectable antibiotic containing Cefepime (a fourth-generation cephalosporin) and Tazobactam (a beta-lactamase inhibitor). It is used to treat severe bacterial infections caused by multidrug-resistant organisms.

Composition

Cefepime – 1 g or 2 g (as Cefepime Hydrochloride)
Tazobactam – 0.125 g or 0.25 g (as Tazobactam Sodium)

*(Commonly available as 1g/0.125g or 2g/0.25g per vial)*

Mechanism of Action

Cefepime:
- A broad-spectrum cephalosporin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
- Effective against Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa.
Tazobactam:
- A beta-lactamase inhibitor that protects Cefepime from degradation by bacterial enzymes (e.g., ESBLs, AmpC beta-lactamases).
- Extends the spectrum of Cefepime against resistant strains.

Dosage & Administration

Standard Adult Dose:
- 1g Cefepime + 0.125g Tazobactam or 2g Cefepime + 0.25g Tazobactam every 8–12 hours via IV infusion (over 30 mins).
Renal Impairment:
- Dose adjustment required based on creatinine clearance (CrCl).
- CrCl 30–60 mL/min: Reduce dose frequency to every 12–24 hrs.
- CrCl < 30 mL/min: Further reduction needed.

Uses (Indications)

Severe infections caused by beta-lactamase-producing bacteria, including:
- Complicated intra-abdominal infections (cIAI)
- Complicated urinary tract infections (cUTI)
- Hospital-acquired pneumonia (HAP) & ventilator-associated pneumonia (VAP)
- Sepsis & bacteremia
- Skin & soft tissue infections (SSTI)

Storage

Unreconstituted vials: Store below 25°C, protect from moisture.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (refrigerated).
- Use immediately if stored at room temperature.
Do not freeze.

Recommendations

Culture & sensitivity testing should guide therapy.
Monitor renal function (adjust dose in renal impairment).
Avoid prolonged use to prevent superinfections (e.g., C. difficile colitis).
Use with caution in patients with penicillin/cephalosporin allergy.

Important Note

Not effective against MRSA (use additional coverage if MRSA suspected).
Cross-hypersensitivity may occur in penicillin-allergic patients.
Pregnancy & Lactation: Use only if clearly needed (Category B).

This combination is reserved for severe, resistant infections and should be used under medical supervision. Always follow local antibiotic guidelines.

Composition

Cefepime – 1 g or 2 g (as Cefepime Hydrochloride)
Tazobactam – 0.125 g or 0.25 g (as Tazobactam Sodium)

*(Commonly available as 1g/0.125g or 2g/0.25g per vial)*

Mechanism of Action

Cefepime:
- A broad-spectrum cephalosporin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
- Effective against Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa.
Tazobactam:
- A beta-lactamase inhibitor that protects Cefepime from degradation by bacterial enzymes (e.g., ESBLs, AmpC beta-lactamases).
- Extends the spectrum of Cefepime against resistant strains.

Dosage & Administration

Standard Adult Dose:
- 1g Cefepime + 0.125g Tazobactam or 2g Cefepime + 0.25g Tazobactam every 8–12 hours via IV infusion (over 30 mins).
Renal Impairment:
- Dose adjustment required based on creatinine clearance (CrCl).
- CrCl 30–60 mL/min: Reduce dose frequency to every 12–24 hrs.
- CrCl < 30 mL/min: Further reduction needed.

Uses (Indications)

Severe infections caused by beta-lactamase-producing bacteria, including:
- Complicated intra-abdominal infections (cIAI)
- Complicated urinary tract infections (cUTI)
- Hospital-acquired pneumonia (HAP) & ventilator-associated pneumonia (VAP)
- Sepsis & bacteremia
- Skin & soft tissue infections (SSTI)

Storage

Unreconstituted vials: Store below 25°C, protect from moisture.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (refrigerated).
- Use immediately if stored at room temperature.
Do not freeze.

Recommendations

Culture & sensitivity testing should guide therapy.
Monitor renal function (adjust dose in renal impairment).
Avoid prolonged use to prevent superinfections (e.g., C. difficile colitis).
Use with caution in patients with penicillin/cephalosporin allergy.

Important Note

Not effective against MRSA (use additional coverage if MRSA suspected).
Cross-hypersensitivity may occur in penicillin-allergic patients.
Pregnancy & Lactation: Use only if clearly needed (Category B).

This combination is reserved for severe, resistant infections and should be used under medical supervision. Always follow local antibiotic guidelines.

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Composition

Cefepime – 1 g or 2 g (as Cefepime Hydrochloride)
Tazobactam – 0.125 g or 0.25 g (as Tazobactam Sodium)

*(Commonly available as 1g/0.125g or 2g/0.25g per vial)*

Mechanism of Action

Cefepime:
- A broad-spectrum cephalosporin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
- Effective against Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa.
Tazobactam:
- A beta-lactamase inhibitor that protects Cefepime from degradation by bacterial enzymes (e.g., ESBLs, AmpC beta-lactamases).
- Extends the spectrum of Cefepime against resistant strains.

Dosage & Administration

Standard Adult Dose:
- 1g Cefepime + 0.125g Tazobactam or 2g Cefepime + 0.25g Tazobactam every 8–12 hours via IV infusion (over 30 mins).
Renal Impairment:
- Dose adjustment required based on creatinine clearance (CrCl).
- CrCl 30–60 mL/min: Reduce dose frequency to every 12–24 hrs.
- CrCl < 30 mL/min: Further reduction needed.

Uses (Indications)

Severe infections caused by beta-lactamase-producing bacteria, including:
- Complicated intra-abdominal infections (cIAI)
- Complicated urinary tract infections (cUTI)
- Hospital-acquired pneumonia (HAP) & ventilator-associated pneumonia (VAP)
- Sepsis & bacteremia
- Skin & soft tissue infections (SSTI)

Storage

Unreconstituted vials: Store below 25°C, protect from moisture.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (refrigerated).
- Use immediately if stored at room temperature.
Do not freeze.

Recommendations

Culture & sensitivity testing should guide therapy.
Monitor renal function (adjust dose in renal impairment).
Avoid prolonged use to prevent superinfections (e.g., C. difficile colitis).
Use with caution in patients with penicillin/cephalosporin allergy.

Important Note

Not effective against MRSA (use additional coverage if MRSA suspected).
Cross-hypersensitivity may occur in penicillin-allergic patients.
Pregnancy & Lactation: Use only if clearly needed (Category B).

This combination is reserved for severe, resistant infections and should be used under medical supervision. Always follow local antibiotic guidelines.

Reviews

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Description
Reviews (0)

Composition

Cefepime – 1 g or 2 g (as Cefepime Hydrochloride)
Tazobactam – 0.125 g or 0.25 g (as Tazobactam Sodium)

*(Commonly available as 1g/0.125g or 2g/0.25g per vial)*

Mechanism of Action

Cefepime:
- A broad-spectrum cephalosporin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
- Effective against Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa.
Tazobactam:
- A beta-lactamase inhibitor that protects Cefepime from degradation by bacterial enzymes (e.g., ESBLs, AmpC beta-lactamases).
- Extends the spectrum of Cefepime against resistant strains.

Dosage & Administration

Standard Adult Dose:
- 1g Cefepime + 0.125g Tazobactam or 2g Cefepime + 0.25g Tazobactam every 8–12 hours via IV infusion (over 30 mins).
Renal Impairment:
- Dose adjustment required based on creatinine clearance (CrCl).
- CrCl 30–60 mL/min: Reduce dose frequency to every 12–24 hrs.
- CrCl < 30 mL/min: Further reduction needed.

Uses (Indications)

Severe infections caused by beta-lactamase-producing bacteria, including:
- Complicated intra-abdominal infections (cIAI)
- Complicated urinary tract infections (cUTI)
- Hospital-acquired pneumonia (HAP) & ventilator-associated pneumonia (VAP)
- Sepsis & bacteremia
- Skin & soft tissue infections (SSTI)

Storage

Unreconstituted vials: Store below 25°C, protect from moisture.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (refrigerated).
- Use immediately if stored at room temperature.
Do not freeze.

Recommendations

Culture & sensitivity testing should guide therapy.
Monitor renal function (adjust dose in renal impairment).
Avoid prolonged use to prevent superinfections (e.g., C. difficile colitis).
Use with caution in patients with penicillin/cephalosporin allergy.

Important Note

Not effective against MRSA (use additional coverage if MRSA suspected).
Cross-hypersensitivity may occur in penicillin-allergic patients.
Pregnancy & Lactation: Use only if clearly needed (Category B).

This combination is reserved for severe, resistant infections and should be used under medical supervision. Always follow local antibiotic guidelines.

Reviews

There are no reviews yet.

Be the first to review “Actamase”

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