Meroza XP

Antibacterial

Description
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MEROZA XP is a sterile, lyophilized powder for intravenous (IV) infusion, combining Meropenem (a carbapenem antibiotic) and Vaborbactam (a beta-lactamase inhibitor). It is used for treating serious multidrug-resistant Gram-negative infections, including those caused by carbapenem-resistant Enterobacteriaceae (CRE).

Composition

Each vial contains:

Meropenem – 1 g
Vaborbactam – 1 g
Excipients: Sodium carbonate (for pH adjustment)

Mechanism of Action

Meropenem:
- Binds to penicillin-binding proteins (PBPs), disrupting bacterial cell wall synthesis.
- Broad-spectrum activity against Gram-positive, Gram-negative, and anaerobic bacteria.
Vaborbactam:
- A non-beta-lactam beta-lactamase inhibitor that protects Meropenem from degradation by Klebsiella pneumoniae carbapenemase (KPC) and other resistant enzymes.

Dosage & Administration

Standard Adult Dose:

4 g (2 g Meropenem + 2 g Vaborbactam) every 8 hours via IV infusion (over 3 hours for optimal efficacy).
Infusion Time: Extended infusion (3 hours) recommended for CRE infections.

Renal Dose Adjustment:

CrCl 30–49 mL/min: 2 g (1g + 1g) every 8 hours
CrCl 15–29 mL/min: 2 g (1g + 1g) every 12 hours
Hemodialysis: Administer after dialysis

Pediatric Use:

Safety & efficacy not established in children.

Uses (Indications)

MEROZA XP is approved for: ✔ Complicated urinary tract infections (cUTIs), including pyelonephritis ✔ Hospital-acquired pneumonia (HAP) & ventilator-associated pneumonia (VAP) ✔ Intra-abdominal infections (with metronidazole for anaerobes) ✔ Bacteremia caused by CRE (Carbapenem-Resistant Enterobacteriaceae)

Storage

Unreconstituted powder: Store at 20–25°C, protect from moisture.
Reconstituted solution:
- Stable for 1 hour at room temperature or 24 hours refrigerated (2–8°C).
- Do not freeze.

Recommendations

✔ Administer as a slow IV infusion (over 3 hours) to maximize efficacy. ✔ Monitor renal function, liver enzymes, and CBC during prolonged therapy. ✔ Not effective against MRSA or Acinetobacter (consider additional coverage if suspected).

Important Note

Contraindications:

Hypersensitivity to carbapenems (e.g., imipenem, ertapenem).
Severe anaphylactic reactions to beta-lactams.

Side Effects:

Common: Diarrhea, headache, nausea, elevated liver enzymes.
Serious: Seizures (in high doses), C. difficile colitis, hypersensitivity.

Drug Interactions:

Valproic acid: Meropenem reduces valproate levels (risk of seizures).
Probenecid: Increases Meropenem concentration (avoid concurrent use).

Pregnancy & Lactation:

Category B (use only if clearly needed).
Breastfeeding: Safety unknown (caution advised).

Composition

Each vial contains:

Meropenem – 1 g
Vaborbactam – 1 g
Excipients: Sodium carbonate (for pH adjustment)

Mechanism of Action

Meropenem:
- Binds to penicillin-binding proteins (PBPs), disrupting bacterial cell wall synthesis.
- Broad-spectrum activity against Gram-positive, Gram-negative, and anaerobic bacteria.
Vaborbactam:
- A non-beta-lactam beta-lactamase inhibitor that protects Meropenem from degradation by Klebsiella pneumoniae carbapenemase (KPC) and other resistant enzymes.

Dosage & Administration

Standard Adult Dose:

4 g (2 g Meropenem + 2 g Vaborbactam) every 8 hours via IV infusion (over 3 hours for optimal efficacy).
Infusion Time: Extended infusion (3 hours) recommended for CRE infections.

Renal Dose Adjustment:

CrCl 30–49 mL/min: 2 g (1g + 1g) every 8 hours
CrCl 15–29 mL/min: 2 g (1g + 1g) every 12 hours
Hemodialysis: Administer after dialysis

Pediatric Use:

Safety & efficacy not established in children.

Uses (Indications)

MEROZA XP is approved for:
✔ Complicated urinary tract infections (cUTIs), including pyelonephritis
✔ Hospital-acquired pneumonia (HAP) & ventilator-associated pneumonia (VAP)
✔ Intra-abdominal infections (with metronidazole for anaerobes)
✔ Bacteremia caused by CRE (Carbapenem-Resistant Enterobacteriaceae)

Storage

Unreconstituted powder: Store at 20–25°C, protect from moisture.
Reconstituted solution:
- Stable for 1 hour at room temperature or 24 hours refrigerated (2–8°C).
- Do not freeze.

Recommendations

✔ Administer as a slow IV infusion (over 3 hours) to maximize efficacy.
✔ Monitor renal function, liver enzymes, and CBC during prolonged therapy.
✔ Not effective against MRSA or Acinetobacter (consider additional coverage if suspected).

Important Note

Contraindications:

Hypersensitivity to carbapenems (e.g., imipenem, ertapenem).
Severe anaphylactic reactions to beta-lactams.

Side Effects:

Common: Diarrhea, headache, nausea, elevated liver enzymes.
Serious: Seizures (in high doses), C. difficile colitis, hypersensitivity.

Drug Interactions:

Valproic acid: Meropenem reduces valproate levels (risk of seizures).
Probenecid: Increases Meropenem concentration (avoid concurrent use).

Pregnancy & Lactation:

Category B (use only if clearly needed).
Breastfeeding: Safety unknown (caution advised).

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Composition

Each vial contains:

Meropenem – 1 g
Vaborbactam – 1 g
Excipients: Sodium carbonate (for pH adjustment)

Mechanism of Action

Meropenem:
- Binds to penicillin-binding proteins (PBPs), disrupting bacterial cell wall synthesis.
- Broad-spectrum activity against Gram-positive, Gram-negative, and anaerobic bacteria.
Vaborbactam:
- A non-beta-lactam beta-lactamase inhibitor that protects Meropenem from degradation by Klebsiella pneumoniae carbapenemase (KPC) and other resistant enzymes.

Dosage & Administration

Standard Adult Dose:

4 g (2 g Meropenem + 2 g Vaborbactam) every 8 hours via IV infusion (over 3 hours for optimal efficacy).
Infusion Time: Extended infusion (3 hours) recommended for CRE infections.

Renal Dose Adjustment:

CrCl 30–49 mL/min: 2 g (1g + 1g) every 8 hours
CrCl 15–29 mL/min: 2 g (1g + 1g) every 12 hours
Hemodialysis: Administer after dialysis

Pediatric Use:

Safety & efficacy not established in children.

Uses (Indications)

MEROZA XP is approved for:
✔ Complicated urinary tract infections (cUTIs), including pyelonephritis
✔ Hospital-acquired pneumonia (HAP) & ventilator-associated pneumonia (VAP)
✔ Intra-abdominal infections (with metronidazole for anaerobes)
✔ Bacteremia caused by CRE (Carbapenem-Resistant Enterobacteriaceae)

Storage

Unreconstituted powder: Store at 20–25°C, protect from moisture.
Reconstituted solution:
- Stable for 1 hour at room temperature or 24 hours refrigerated (2–8°C).
- Do not freeze.

Recommendations

✔ Administer as a slow IV infusion (over 3 hours) to maximize efficacy.
✔ Monitor renal function, liver enzymes, and CBC during prolonged therapy.
✔ Not effective against MRSA or Acinetobacter (consider additional coverage if suspected).

Important Note

Contraindications:

Hypersensitivity to carbapenems (e.g., imipenem, ertapenem).
Severe anaphylactic reactions to beta-lactams.

Side Effects:

Common: Diarrhea, headache, nausea, elevated liver enzymes.
Serious: Seizures (in high doses), C. difficile colitis, hypersensitivity.

Drug Interactions:

Valproic acid: Meropenem reduces valproate levels (risk of seizures).
Probenecid: Increases Meropenem concentration (avoid concurrent use).

Pregnancy & Lactation:

Category B (use only if clearly needed).
Breastfeeding: Safety unknown (caution advised).

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Description
Reviews (0)

Composition

Each vial contains:

Meropenem – 1 g
Vaborbactam – 1 g
Excipients: Sodium carbonate (for pH adjustment)

Mechanism of Action

Meropenem:
- Binds to penicillin-binding proteins (PBPs), disrupting bacterial cell wall synthesis.
- Broad-spectrum activity against Gram-positive, Gram-negative, and anaerobic bacteria.
Vaborbactam:
- A non-beta-lactam beta-lactamase inhibitor that protects Meropenem from degradation by Klebsiella pneumoniae carbapenemase (KPC) and other resistant enzymes.

Dosage & Administration

Standard Adult Dose:

4 g (2 g Meropenem + 2 g Vaborbactam) every 8 hours via IV infusion (over 3 hours for optimal efficacy).
Infusion Time: Extended infusion (3 hours) recommended for CRE infections.

Renal Dose Adjustment:

CrCl 30–49 mL/min: 2 g (1g + 1g) every 8 hours
CrCl 15–29 mL/min: 2 g (1g + 1g) every 12 hours
Hemodialysis: Administer after dialysis

Pediatric Use:

Safety & efficacy not established in children.

Uses (Indications)

MEROZA XP is approved for:
✔ Complicated urinary tract infections (cUTIs), including pyelonephritis
✔ Hospital-acquired pneumonia (HAP) & ventilator-associated pneumonia (VAP)
✔ Intra-abdominal infections (with metronidazole for anaerobes)
✔ Bacteremia caused by CRE (Carbapenem-Resistant Enterobacteriaceae)

Storage

Unreconstituted powder: Store at 20–25°C, protect from moisture.
Reconstituted solution:
- Stable for 1 hour at room temperature or 24 hours refrigerated (2–8°C).
- Do not freeze.

Recommendations

✔ Administer as a slow IV infusion (over 3 hours) to maximize efficacy.
✔ Monitor renal function, liver enzymes, and CBC during prolonged therapy.
✔ Not effective against MRSA or Acinetobacter (consider additional coverage if suspected).

Important Note

Contraindications:

Hypersensitivity to carbapenems (e.g., imipenem, ertapenem).
Severe anaphylactic reactions to beta-lactams.

Side Effects:

Common: Diarrhea, headache, nausea, elevated liver enzymes.
Serious: Seizures (in high doses), C. difficile colitis, hypersensitivity.

Drug Interactions:

Valproic acid: Meropenem reduces valproate levels (risk of seizures).
Probenecid: Increases Meropenem concentration (avoid concurrent use).

Pregnancy & Lactation:

Category B (use only if clearly needed).
Breastfeeding: Safety unknown (caution advised).

Reviews

There are no reviews yet.

Be the first to review “Meroza XP”

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