PRIMOLUT N is an oral hormonal preparation containing Norethisterone, a synthetic progestogen. It is primarily used for menstrual disorders, endometriosis, and contraception support.
Composition
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Active Ingredient:
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Norethisterone (5 mg per tablet).
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Excipients:Â Lactose, maize starch, magnesium stearate.
Mechanism of Action
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Progestogenic Effect:
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Suppresses endometrial proliferation, preventing abnormal uterine bleeding.
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Inhibits ovulation by negative feedback on the pituitary gland.
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Anti-Estrogenic Effect:
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Counteracts estrogen-driven conditions like endometriosis.
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Dosage & Administration
For Menstrual Disorders (e.g., heavy bleeding):
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5 mg 3 times daily for 10 days (to stop bleeding), then 5 mg twice daily for maintenance.
For Endometriosis:
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5 mg daily for 6–9 months (start on Day 1 of the cycle).
For Contraception (with estrogen):
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Combined with estrogen in COCs (specific regimen varies).
Missed Dose:
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Take as soon as remembered; avoid doubling doses.
Uses (Indications)
✔ Dysfunctional uterine bleeding (DUB).
✔ Endometriosis management.
✔ Secondary amenorrhea.
✔ Contraception support (in combined pills).
✔ Premenstrual syndrome (PMS).
Storage
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Store below 30°C in a dry place.
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Keep away from children.
Recommendations
✔ Take at the same time daily for consistent effects.
✔ Monitor for mood changes, weight gain, or breakthrough bleeding.
✔ Not for long-term use without medical supervision.
Important Note
Contraindications:
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Pregnancy (risk of fetal harm).
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History of thromboembolism, liver tumors, or hormone-sensitive cancers.
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Severe hypertension or diabetes with vascular complications.
Side Effects:
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Common:Â Nausea, breast tenderness, headache.
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Serious:
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Venous thromboembolism (rare).
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Jaundice (hepatic dysfunction).
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Drug Interactions:
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Rifampicin, Carbamazepine: ↓ Progestin efficacy.
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Warfarin:Â Alters anticoagulant effect.
Pregnancy & Lactation:
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Avoid in pregnancy (teratogenic risk).
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Lactation:Â Safe in small doses; monitor infant.
Presentation
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Strip of 10 tablets (5 mg each).
Disclaimer:Â Use under medical supervision for hormonal conditions.
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