SUSTEN 200 is an oral progesterone preparation used for hormone replacement therapy (HRT) and menstrual cycle regulation. Each soft gelatin capsule contains 200 mg micronized progesterone for better absorption.
Composition
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Active Ingredient: Progesterone 200 mg (micronized for enhanced bioavailability).
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Inactive Ingredients: Soybean oil, gelatin, glycerin, titanium dioxide.
Mechanism of Action
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Natural progesterone binds to progesterone receptors in the uterus, ovaries, and brain.
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Supports endometrial maturation (for pregnancy maintenance).
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Balances estrogen effects (prevents endometrial hyperplasia in HRT).
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Inhibits ovulation at high doses (luteal phase support).
Dosage & Administration
Common Indications & Dosing
Condition | Dosage | Duration |
---|---|---|
Luteal phase defect | 200 mg 2x/day (vaginal/oral) | From ovulation → 12 weeks gestation |
HRT (with estrogen) | 200 mg/day (cyclic or continuous) | 12–14 days/month |
Secondary amenorrhea | 200–400 mg/day × 10 days | Cyclic therapy |
Administration Notes
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Best taken at bedtime (sedative effect aids sleep).
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With food to improve absorption.
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Vaginal use: Insert deeply (off-label for IVF support).
Indications
✅ Infertility treatment (luteal phase support).
✅ Hormone replacement therapy (HRT) in postmenopausal women.
✅ Secondary amenorrhea.
✅ Prevention of endometrial hyperplasia (in estrogen therapy).
Storage & Stability
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Store below 25°C, protect from moisture/light.
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Do not freeze (softgel may rupture).
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Shelf life: Typically 2–3 years.
Key Recommendations
✔ Monitor for breakthrough bleeding (adjust dose if needed).
✔ Avoid in active thromboembolic disorders (↑ risk of blood clots).
✔ Caution in hepatic impairment (alters metabolism).
Important Safety Notes
âš Â Pregnancy (Category B): Safe for luteal support but avoid unnecessary use.
âš Â Breast cancer risk: Avoid in estrogen-dependent cancers.
âš Â Side effects: Drowsiness, dizziness, bloating.
Comparison with Other Progesterones
Feature | SUSTEN 200 | Medroxyprogesterone | Dydrogesterone |
---|---|---|---|
Bioavailability | High (micronized) | Moderate | High |
Sedation | Yes (calming effect) | No | Minimal |
Breastfeeding | Compatible | Avoid | Compatible |
Conclusion
SUSTEN 200 is a versatile progesterone option for fertility support & HRT, with better tolerability than synthetic progestins.
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