ULTROGESTAN 200 mg is a natural micronized progesterone preparation available in soft gelatin capsules for oral or vaginal use. It is widely used in hormone replacement therapy (HRT), fertility treatments, and menstrual disorders.
Composition
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Active Ingredient: Natural Progesterone 200 mg (micronized for better absorption).
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Vehicle: Peanut oil, soy lecithin, gelatin, glycerin.
(Contains no synthetic progestins – bioidentical to human progesterone.)
Mechanism of Action
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Binds to progesterone receptors in the endometrium, ovaries, and brain.
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Prepares the uterus for implantation (luteal phase support in IVF).
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Balances estrogen effects (prevents endometrial hyperplasia in HRT).
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Suppresses ovulation at high doses.
Dosage & Administration
By Indication
Condition | Dosage | Route | Duration |
---|---|---|---|
Luteal Phase Support (IVF) | 200–400 mg/day | Vaginal (preferred) | From embryo transfer → 10–12 weeks gestation |
HRT (with Estrogen) | 200 mg/day | Oral/Vaginal | 12–14 days/month |
Secondary Amenorrhea | 200–300 mg/day | Oral | 10–12 days/month |
Premenstrual Syndrome (PMS) | 200–300 mg/day | Oral | Luteal phase (Day 14–28) |
Key Notes
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Vaginal route has higher uterine bioavailability (less systemic side effects).
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Oral administration causes drowsiness (take at bedtime).
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With food to enhance absorption.
Indications
✅ Assisted reproduction (IVF/IUI support)
✅ Hormone replacement therapy (HRT) in postmenopausal women
✅ Menstrual irregularities (amenorrhea, heavy bleeding)
✅ Premenstrual syndrome (PMS) & PMDD
Storage & Stability
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Store below 25°C (protect from light & moisture).
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Do not freeze (soft capsules may rupture).
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Shelf life: 3 years.
Key Recommendations
✔ Vaginal use preferred in IVF (higher endometrial effect).
✔ Monitor for breakthrough bleeding (adjust dose if needed).
✔ Avoid in active thromboembolic disorders (minimal risk vs. synthetic progestins).
Important Safety Notes
âš Â Pregnancy (Category B): Safe in pregnancy for luteal support.
âš Â Breastfeeding: Compatible (low milk transfer).
âš Â Contraindications:
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Undiagnosed vaginal bleeding
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Severe liver disease
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Progesterone-sensitive cancers
âš Â Side Effects:
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Common: Drowsiness (oral), vaginal discharge (vaginal).
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Rare: Allergic reactions (peanut/soy allergy warning).
Comparison with Other Progesterones
Feature | ULTROGESTAN | Medroxyprogesterone | Dydrogesterone |
---|---|---|---|
Type | Natural micronized | Synthetic | Synthetic (retroprogesterone) |
Drowsiness | High (oral) | Minimal | Minimal |
Thrombosis Risk | Low | Moderate | Low |
IVF Use | Preferred (vaginal) | Not used | Alternative |
Why Choose ULTROGESTAN?
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Bioidentical hormone (no androgenic side effects).
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Flexible administration (oral/vaginal).
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Well-tolerated in long-term HRT.
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