FOLICULIN 75 is a recombinant FSH (rFSH) injection used in fertility treatments to stimulate ovarian follicle development in women and sperm production in men with hypogonadotropic hypogonadism. It contains 75 IU of follitropin alfa/beta per vial, providing a lower-dose option for controlled ovarian stimulation.
Composition
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Active Ingredient:Â Follitropin alfa/beta 75 IUÂ (recombinant human FSH).
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Form: Lyophilized powder (with solvent for reconstitution).
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Purity: Highly purified (no LH activity, minimal proteins).
Mechanism of Action
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Stimulates ovarian follicle growth in women (promotes egg maturation).
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Supports spermatogenesis in men with low FSH levels.
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Used in ovulation induction and assisted reproductive technologies (ART)Â like IVF/IUI.
Dosage & Administration
For Women
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Ovulation Induction (OI): 75–150 IU/day SC/IM (adjust based on response).
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IVF/ICSI: 75–225 IU/day (individualized based on ovarian reserve).
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Duration: Typically 7–14 days (until follicles reach 17–20 mm).
For Men
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75–150 IU 2–3x/week (combined with hCG for spermatogenesis).
Reconstitution & Injection
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Reconstitute with provided solvent.
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Inject subcutaneously (preferred) or intramuscularly.
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Rotate injection sites (to avoid skin reactions).
Indications
✅ Anovulatory infertility (e.g., PCOS, hypothalamic dysfunction).
✅ Controlled ovarian stimulation (IVF/IUI).
✅ Male infertility due to hypogonadotropic hypogonadism.
Storage & Stability
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Unopened vials: Store at 2–8°C (refrigerate; do not freeze).
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After reconstitution: Use immediately (discard unused portions).
Key Recommendations
✔ Start with lower doses (especially in PCOS/high responders).
✔ Monitor via ultrasound & estradiol levels (prevents OHSS).
✔ Adjust dose based on follicle growth (avoid overstimulation).
Important Safety Notes
⚠ Ovarian Hyperstimulation Syndrome (OHSS) Risk – Requires close monitoring.
⚠ Multiple Pregnancy Risk – Higher with fertility treatments.
âš Â Contraindications:
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Ovarian/testicular tumors
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Pregnancy
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Uncontrolled thyroid/adrenal disorders
Comparison with Other FSH Preparations
Feature | FOLICULIN 75 (rFSH) | hMG (Menopur) | Clomiphene Citrate |
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Hormone Type | Pure FSH | FSH + LH | Oral anti-estrogen |
Purity | Recombinant (no LH) | Urinary-derived | N/A |
Male Use | Yes | Yes | No |
Cost | Moderate-High | Moderate | Low |
Conclusion
FOLICULIN 75 is an effective, lower-dose rFSH option for ovulation induction and ART, offering better control in sensitive patients (e.g., PCOS).
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