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Brand Name: BHARGLOB
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Generic Name: Human Chorionic Gonadotropin (hCG)
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Therapeutic Class: Gonadotropin hormone
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Presentation:
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Lyophilized powder in vials (1000 IU, 2000 IU, 5000 IU, 10000 IU)
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With solvent for reconstitution
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2. Composition
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Active Ingredient: hCG (purified from human urine)
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Excipients:
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Mannitol (stabilizer)
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Sodium phosphate (buffer)
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Albumin human (stabilizer)
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3. Mechanism of Action
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In Women:
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Mimics LH surge to trigger final oocyte maturation
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Induces ovulation within 36-48 hours
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Supports corpus luteum formation
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In Men:
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Stimulates Leydig cells to produce testosterone
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Maintains spermatogenesis when combined with FSH
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4. Dosage and Administration
For Women (Ovulation Trigger)
Indication | Standard Dose | Timing |
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Ovulation Induction | 5000-10000 IU | When lead follicle reaches 18-20mm |
ART Cycles | 5000-10000 IU or 250mcg r-hCG | 34-36 hours before retrieval |
For Men (Hypogonadism)
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1000-2000 IU IM 2-3 times weekly
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Often combined with FSH for spermatogenesis
Administration
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Reconstitute with provided solvent
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Administer via deep IM injection
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Preferred sites: Gluteal or deltoid muscle
5. Indications
✔ Ovulation induction in anovulatory women
✔ Final follicular maturation in ART cycles
✔ Corpus luteum support in luteal phase defects
✔ Male hypogonadotropic hypogonadism
✔ Cryptorchidism in prepubertal boys (off-label)
6. Storage Conditions
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Unreconstituted:
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Store at 2-8°C (refrigerate)
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Protect from light
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Reconstituted:
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Use immediately
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Discard unused portions
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Do not freeze
7. Key Recommendations
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For ART cycles:
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Time administration precisely (34-36h before retrieval)
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Cancel cycle if >30 follicles >12mm (OHSS risk)
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For male patients:
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Monitor testosterone levels
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Combine with FSH for spermatogenesis
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Treatment duration ≥3 months for sperm production
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8. Important Safety Information
Warnings
⚠ Ovarian Hyperstimulation Syndrome (OHSS)
⚠ Multiple pregnancies (up to 30% risk)
⚠ Androgen-related effects in men (acne, fluid retention)
Contraindications
❌ Ovarian/testicular cancer
❌ Pituitary tumors
❌ Uncontrolled thyroid/adrenal dysfunction
❌ Hypersensitivity to hCG preparations
Adverse Effects
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Women: OHSS, injection site pain, headache
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Men: Gynecomastia, acne, mood changes
9. Comparison with Other hCG Products
Parameter | BHARGLOB | Recombinant hCG | Urinary hCG |
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Source | Urinary | Recombinant | Urinary |
Purity | High | Ultra-high | Moderate |
Cost | $$ | $$$ | $ |
Dosing | 1000-10000 IU | 250mcg equivalent | 1000-10000 IU |
10. Patient Counseling
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Importance of precise timing for ovulation trigger
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OHSS warning signs to report:
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Severe abdominal pain
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Nausea/vomiting
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Difficulty breathing
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For male patients:
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Expected timeline for spermatogenesis (3-6 months)
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Potential androgenic side effects
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11. Regulatory Status
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Prescription-only medication
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Requires specialist supervision for fertility use
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Pregnancy Category X (contraindicated in pregnancy except for ART)
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