HUCOG 10000 HP is a highly purified urinary-derived hCG preparation containing 10,000 IU per vial. It is used for:
-
Triggering final follicular maturation and ovulation in women
-
Supporting corpus luteum function
-
Treating male hypogonadotropic hypogonadism
Composition
-
Active Ingredient: Human Chorionic Gonadotropin (hCG) 10,000 IU
-
Source: Purified from human urine
-
Form: Lyophilized powder with 1 mL sterile water for reconstitution
-
Excipients: Mannitol, sodium phosphate, human albumin
Mechanism of Action
-
In Women:
-
Mimics LH surge → induces final oocyte maturation
-
Triggers ovulation within 36-42 hours
-
Supports progesterone production by corpus luteum
-
-
In Men:
-
Stimulates testosterone production from Leydig cells
-
Maintains spermatogenesis (when combined with FSH)
-
Dosage & Administration
For Women (Ovulation Trigger)
Indication | Dose | Timing |
---|---|---|
Ovulation Induction | 5,000-10,000 IU | When dominant follicle reaches 18-20mm |
ART Cycles | 5,000-10,000 IU | 34-36 hours before oocyte retrieval |
For Men
-
Hypogonadism: 1,000-2,000 IU IM 2-3 times weekly
-
Spermatogenesis Induction: Combine with FSH (75-150 IU 3x/week)
Administration
-
Reconstitute with provided solvent
-
Inject deeply IMÂ (gluteal or deltoid)
-
Time precisely for ART cycles
Storage & Stability
-
Unreconstituted: 2-8°C (refrigerate)
-
After reconstitution: Use immediately
-
Do not freeze
-
Protect from light
Key Recommendations
✔ For ART:
-
Cancel cycle if >20 follicles >12mm (OHSS risk)
-
Consider GnRH agonist trigger for high responders
✔ For Men:
-
Monitor testosterone levels
-
Minimum 3-6 months treatment for spermatogenesis
✔ Always confirm:
-
Absence of pregnancy before use
-
Normal renal function
Important Safety Notes
âš Â Black Box Warnings:
-
Ovarian Hyperstimulation Syndrome (OHSS)
-
Arterial thromboembolism (higher risk with OHSS)
âš Â Contraindications:
-
Ovarian/testicular cancer
-
Uncontrolled thyroid/adrenal dysfunction
-
Precocious puberty
-
Hypersensitivity to hCG preparations
âš Â Adverse Effects:
-
Women: OHSS, injection site reactions
-
Men: Gynecomastia, androgen excess
Comparison with Other hCG Preparations
Feature | HUCOG 10000 HP | Recombinant hCG |
---|---|---|
Source | Urinary | Recombinant |
Purity | >95% | >99% |
Dose Equivalent | 10,000 IU | 250 mcg |
Cost | $$ | $$$$ |
Conclusion
HUCOG 10000 HP is a cost-effective hCG option for:
-
Ovulation triggering in fertility treatments
-
Male hypogonadism management
Requires careful monitoring for OHSS and proper timing in ART cycles.
Reviews
There are no reviews yet.