HUCOG 2000 HP is a highly purified urinary-derived hCG preparation containing 2,000 IU per vial. It is primarily used for:
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Luteal phase support in fertility treatments
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Mild ovulation induction
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Low-dose hCG supplementation in ART cycles
Key Specifications
Parameter | Details |
---|---|
Active Ingredient | Human Chorionic Gonadotropin (hCG) |
Strength | 2,000 IU per vial |
Source | Purified from human urine |
Formulation | Lyophilized powder with 1 mL solvent |
Purity Level | >95% pure |
Administration Route | Intramuscular (preferred) or Subcutaneous |
Clinical Applications
1. Female Fertility
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Luteal Phase Support:
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1,500-2,000 IU every 3-5 days post-ovulation
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Enhances progesterone production
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Mild Ovulation Induction:
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2,000-5,000 IU when lead follicle reaches 17-18mm
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2. Male Fertility
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Hypogonadotropic Hypogonadism:
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1,000-2,000 IU 2-3 times weekly
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Combined with FSH for spermatogenesis
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Dosage Guidelines
For Luteal Phase Support
Protocol | Dose | Frequency | Duration |
---|---|---|---|
Standard | 2,000 IU | Every 3 days | Until pregnancy test |
Intensive | 1,500 IU | Every 2 days | Up to 10 weeks gestation |
For Mild Stimulation Cycles
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Step-up Protocol:
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Start with 2,000 IU
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Additional 1,000 IU after 24h if needed
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Maximum total dose: 5,000 IU per cycle
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Pharmacological Properties
Pharmacokinetics
Parameter | Value |
---|---|
Time to peak | 6-12 hours |
Half-life | 24-36 hours |
Clearance | Renal (30%) and hepatic |
Biological Effects
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Onset of LH-like activity: Within 2 hours
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Duration of action: 3-5 days
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Ovulation window: 36-42 hours post-injection
Safety Profile
Adverse Effects
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Common (≥5%):
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Injection site reactions
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Mild ovarian enlargement
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Headache
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Serious (<1%):
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Ovarian hyperstimulation
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Thromboembolic events
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Ovarian torsion
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Risk Minimization
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OHSS Prevention:
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Cancel cycle if E2 >4,000 pg/mL
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Coasting strategy for high responders
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Avoid in PCOS patients with >15 follicles
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Storage & Handling
Storage Conditions
State | Temperature | Duration |
---|---|---|
Unreconstituted | 2-8°C | Until expiry |
Reconstituted | 2-8°C | 24 hours |
Room temperature | ≤25°C | 6 hours |
Reconstitution Protocol
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Add 1 mL provided solvent
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Swirl gently (do not shake)
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Inspect for clarity before use
Cost Comparison
Preparation | Cost per 1,000 IU | Advantages |
---|---|---|
HUCOG 2000 HP | $X | Cost-effective for luteal support |
Recombinant hCG | $3X | More precise dosing |
Urinary hCG | $0.8X | Lower purity |
Clinical Pearls
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For Frozen Embryo Transfers:
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Ideal for natural cycle support
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Start 2,000 IU on ovulation day +3
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In Male Infertility:
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Combine with 75 IU FSH 3x/week
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Semen analysis every 3 months
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ART Considerations:
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Can be used for dual trigger (with GnRH agonist)
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Reduces OHSS risk compared to 5,000 IU doses
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Regulatory Information
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Pregnancy Category: X
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Prescription Status: Specialist-only prescription
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Therapeutic Index: Narrow (requires precise dosing)
Reviews
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