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Brand Name: HUCOG HCG 5000 HP
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Generic Name: Human Chorionic Gonadotropin (hCG)
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Source: Urinary-derived, highly purified (≤1% impurities)
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Form: Lyophilized powder (5000 IU/vial) + 1 mL sterile solvent
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Administration: IM/Subcutaneous injection
2. Composition
Component | Function |
---|---|
hCG 5000 IU | Active glycoprotein hormone |
Mannitol | Stabilizer |
Sodium Phosphate | Buffer |
Human Albumin | Solubility enhancer |
(Latex-free vial stopper in newer formulations)
3. Mechanism of Action
✔ In Women:
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Mimics LH surge → triggers ovulation (36-42h post-injection)
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Supports corpus luteum progesterone production
✔ In Men:
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Stimulates Leydig cells → boosts testosterone
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Maintains spermatogenesis (with FSH co-treatment)
✔ In Prepubertal Boys:
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Treats cryptorchidism (off-label)
4. Dosage & Administration
For Women
Indication | Dose | Timing |
---|---|---|
Ovulation Trigger | 5000-10000 IU | When follicle reaches 18-20mm |
Luteal Support | 1500 IU q3d | Post-ovulation → 10 weeks gestation |
For Men
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Hypogonadism: 1000-2000 IU IM 2-3x/week
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Fertility: 2000 IU + 75 IU FSH 3x/week
Reconstitution
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Add 1 mL solvent → swirl gently (do not shake)
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Inject IM (gluteal/deltoid) or SubQ
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Time precisely for ART cycles
5. Indications
✅ ART Cycles (IVF/IUI ovulation trigger)
✅ Anovulatory Infertility (PCOS/hypothalamic)
✅ Male Hypogonadotropic Hypogonadism
✅ Corpus Luteum Insufficiency
(Not for weight loss or athletic enhancement)
6. Storage & Stability
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Unreconstituted: 2-8°C (refrigerate; do not freeze)
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Reconstituted: Use immediately (discard leftovers)
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Travel: Stable ≤25°C for ≤30 days if unopened
7. Key Recommendations
✔ For ART:
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Cancel cycle if >20 follicles >12mm (OHSS risk)
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Use GnRH agonist trigger for high responders
✔ For Men:
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Monitor testosterone & semen analysis q3mo
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Combine with FSH for spermatogenesis
✔ Always confirm:
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No pregnancy before use
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Normal renal function
8. Important Safety Notes
⚠ Black Box Warnings:
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Ovarian Hyperstimulation Syndrome (OHSS)
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Arterial Thromboembolism (↑ with OHSS)
⚠ Contraindications:
❌ Ovarian/testicular cancer
❌ Uncontrolled thyroid/adrenal disease
❌ Precocious puberty
⚠ Adverse Effects:
Women | Men |
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OHSS | Gynecomastia |
Multiples | Androgen excess |
Injection pain | Fluid retention |
9. Comparison with Recombinant hCG
Parameter | HUCOG 5000 HP | Recombinant hCG |
---|---|---|
Source | Urinary | Cell culture |
Cost per 5000 IU | 15−30 | 100−200 |
Purity | >95% | >99% |
LH Activity | Yes | Minimal |
10. Patient Counseling
✔ Report immediately:
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Severe abdominal pain/distension (OHSS)
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Shortness of breath (thromboembolism)
✔ Fertility patients:
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Precise timed intercourse/IUI after injection
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Avoid NSAIDs post-trigger (impairs implantation)
✔ Male patients:
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3-6 month minimum for spermatogenesis
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Monitor testicular volume
Conclusion
HUCOG 5000 HP is a cost-effective hCG for:
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Reliable ovulation triggering
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Male hypogonadism management
Requires strict OHSS vigilance in fertility cycles.
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