PREMARIN VAGINAL CREAM

Women Health

Description
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Brand Name: Premarin Vaginal Cream
Generic Name: Conjugated Estrogens (USP)
Therapeutic Class: Topical Estrogen Therapy
Formulation: 0.625 mg conjugated estrogens per gram of cream
Delivery System: Graduated applicator for precise dosing

2. COMPOSITION

Component	Concentration	Purpose
Conjugated Estrogens (USP)	0.625 mg/g	Active ingredient
Cetyl Esters Wax	7%	Emollient base
Glycerin	5%	Humectant
Propylene Glycol	3%	Solvent/Preservative
Methylparaben	0.18%	Preservative

3. MECHANISM OF ACTION

Local estrogenic effects on vaginal epithelium:
- Restores vaginal pH (↓ from ~6.0 to ~4.5)
- Increases blood flow to urogenital tissues
- Thickens vaginal epithelium (maturation index improvement)
- Enhances cervical mucus production
Minimal systemic absorption:
- Serum estradiol levels typically remain in postmenopausal range
- First-pass hepatic metabolism avoided

4. DOSAGE & ADMINISTRATION

Standard Dosing Schedule

Phase	Dose (g)	Estrogen Content	Frequency	Duration
Initial	0.5-2 g	0.31-1.25 mg	Daily	2-4 weeks
Maintenance	0.5-1 g	0.31-0.625 mg	2-3× weekly	Ongoing

Administration Guide

Wash hands before application
Fill applicator to prescribed dose marking
Insert deeply into vagina (best at bedtime)
Avoid intercourse for 1 hour post-application

5. INDICATIONS

✅ Moderate-to-severe dyspareunia due to menopause ✅ Vaginal dryness/itching/burning (vulvovaginal atrophy) ✅ Urinary symptoms (dysuria, urgency) from urogenital atrophy ✅ Pre-procedure preparation for postmenopausal pelvic surgery

6. STORAGE CONDITIONS

Temperature: 20-25°C (68-77°F)
Post-Opening: Use within 3 months
Protection: Keep tube tightly closed
Do not freeze

7. KEY RECOMMENDATIONS

✔ Start with lowest effective dose (0.5 g daily) ✔ Re-evaluate need every 3-6 months (consider non-hormonal alternatives) ✔ Use vaginal moisturizers concomitantly for optimal symptom relief ✔ Monitor endometrial thickness if used >1 year (transvaginal ultrasound)

8. IMPORTANT SAFETY INFORMATION

Black Box Warnings

⚠ Endometrial Cancer Risk:

Unopposed estrogen increases risk (add progestogen if uterus present)
Monitor for abnormal bleeding

⚠ Cardiovascular/Thromboembolic Risks:

Lower than oral estrogens but still present

Contraindications

❌ Undiagnosed vaginal bleeding ❌ Estrogen-dependent neoplasia ❌ Active arterial thromboembolism ❌ Pregnancy (Category X)

Adverse Effects

Common (≥5%)	Serious (<1%)
Vaginal spotting	Endometrial hyperplasia
Breast tenderness	Venous thromboembolism
Headache	Gallbladder disease

9. COMPARISON WITH OTHER VAGINAL ESTROGENS

Parameter	Premarin Cream	Estradiol Tablet	Vaginal Ring
Estrogen Type	Conjugated	17β-estradiol	Estradiol acetate
Dosing Frequency	2-3× weekly	Daily	Every 3 months
Systemic Absorption	Low	Very low	Low
Cost/Month	$$	$	$$$

10. PATIENT COUNSELING POINTS

✔ Proper applicator cleaning (wash with mild soap after use) ✔ Expected timeline for improvement (full effects in 1-3 months) ✔ Warning signs to report:

New breast lumps
Severe headaches
Visual changes
Leg pain/swelling

✔ Alternate options:

Non-hormonal moisturizers (e.g., Replens)
Regular sexual activity to maintain blood flow

CONCLUSION

Premarin Vaginal Cream provides effective localized estrogen therapy for urogenital atrophy with minimal systemic effects. While safer than oral estrogens, it still requires regular monitoring and should be used at the lowest effective dose for the shortest duration.

Brand Name: Premarin Vaginal Cream
Generic Name: Conjugated Estrogens (USP)
Therapeutic Class: Topical Estrogen Therapy
Formulation: 0.625 mg conjugated estrogens per gram of cream
Delivery System: Graduated applicator for precise dosing

2. COMPOSITION

Component	Concentration	Purpose
Conjugated Estrogens (USP)	0.625 mg/g	Active ingredient
Cetyl Esters Wax	7%	Emollient base
Glycerin	5%	Humectant
Propylene Glycol	3%	Solvent/Preservative
Methylparaben	0.18%	Preservative

3. MECHANISM OF ACTION

Local estrogenic effects on vaginal epithelium:
- Restores vaginal pH (↓ from ~6.0 to ~4.5)
- Increases blood flow to urogenital tissues
- Thickens vaginal epithelium (maturation index improvement)
- Enhances cervical mucus production
Minimal systemic absorption:
- Serum estradiol levels typically remain in postmenopausal range
- First-pass hepatic metabolism avoided

4. DOSAGE & ADMINISTRATION

Standard Dosing Schedule

Phase	Dose (g)	Estrogen Content	Frequency	Duration
Initial	0.5-2 g	0.31-1.25 mg	Daily	2-4 weeks
Maintenance	0.5-1 g	0.31-0.625 mg	2-3× weekly	Ongoing

Administration Guide

Wash hands before application
Fill applicator to prescribed dose marking
Insert deeply into vagina (best at bedtime)
Avoid intercourse for 1 hour post-application

5. INDICATIONS

✅ Moderate-to-severe dyspareunia due to menopause
✅ Vaginal dryness/itching/burning (vulvovaginal atrophy)
✅ Urinary symptoms (dysuria, urgency) from urogenital atrophy
✅ Pre-procedure preparation for postmenopausal pelvic surgery

6. STORAGE CONDITIONS

Temperature: 20-25°C (68-77°F)
Post-Opening: Use within 3 months
Protection: Keep tube tightly closed
Do not freeze

7. KEY RECOMMENDATIONS

✔ Start with lowest effective dose (0.5 g daily)
✔ Re-evaluate need every 3-6 months (consider non-hormonal alternatives)
✔ Use vaginal moisturizers concomitantly for optimal symptom relief
✔ Monitor endometrial thickness if used >1 year (transvaginal ultrasound)

8. IMPORTANT SAFETY INFORMATION

Black Box Warnings

⚠ Endometrial Cancer Risk:

Unopposed estrogen increases risk (add progestogen if uterus present)
Monitor for abnormal bleeding

⚠ Cardiovascular/Thromboembolic Risks:

Lower than oral estrogens but still present

Contraindications

❌ Undiagnosed vaginal bleeding
❌ Estrogen-dependent neoplasia
❌ Active arterial thromboembolism
❌ Pregnancy (Category X)

Adverse Effects

Common (≥5%)	Serious (<1%)
Vaginal spotting	Endometrial hyperplasia
Breast tenderness	Venous thromboembolism
Headache	Gallbladder disease

9. COMPARISON WITH OTHER VAGINAL ESTROGENS

Parameter	Premarin Cream	Estradiol Tablet	Vaginal Ring
Estrogen Type	Conjugated	17β-estradiol	Estradiol acetate
Dosing Frequency	2-3× weekly	Daily	Every 3 months
Systemic Absorption	Low	Very low	Low
Cost/Month	$$	$	$$$

10. PATIENT COUNSELING POINTS

✔ Proper applicator cleaning (wash with mild soap after use)
✔ Expected timeline for improvement (full effects in 1-3 months)
✔ Warning signs to report:

New breast lumps
Severe headaches
Visual changes
Leg pain/swelling

✔ Alternate options:

Non-hormonal moisturizers (e.g., Replens)
Regular sexual activity to maintain blood flow

CONCLUSION

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Brand Name: Premarin Vaginal Cream
Generic Name: Conjugated Estrogens (USP)
Therapeutic Class: Topical Estrogen Therapy
Formulation: 0.625 mg conjugated estrogens per gram of cream
Delivery System: Graduated applicator for precise dosing

2. COMPOSITION

Component	Concentration	Purpose
Conjugated Estrogens (USP)	0.625 mg/g	Active ingredient
Cetyl Esters Wax	7%	Emollient base
Glycerin	5%	Humectant
Propylene Glycol	3%	Solvent/Preservative
Methylparaben	0.18%	Preservative

3. MECHANISM OF ACTION

Local estrogenic effects on vaginal epithelium:
- Restores vaginal pH (↓ from ~6.0 to ~4.5)
- Increases blood flow to urogenital tissues
- Thickens vaginal epithelium (maturation index improvement)
- Enhances cervical mucus production
Minimal systemic absorption:
- Serum estradiol levels typically remain in postmenopausal range
- First-pass hepatic metabolism avoided

4. DOSAGE & ADMINISTRATION

Standard Dosing Schedule

Phase	Dose (g)	Estrogen Content	Frequency	Duration
Initial	0.5-2 g	0.31-1.25 mg	Daily	2-4 weeks
Maintenance	0.5-1 g	0.31-0.625 mg	2-3× weekly	Ongoing

Administration Guide

Wash hands before application
Fill applicator to prescribed dose marking
Insert deeply into vagina (best at bedtime)
Avoid intercourse for 1 hour post-application

5. INDICATIONS

✅ Moderate-to-severe dyspareunia due to menopause
✅ Vaginal dryness/itching/burning (vulvovaginal atrophy)
✅ Urinary symptoms (dysuria, urgency) from urogenital atrophy
✅ Pre-procedure preparation for postmenopausal pelvic surgery

6. STORAGE CONDITIONS

Temperature: 20-25°C (68-77°F)
Post-Opening: Use within 3 months
Protection: Keep tube tightly closed
Do not freeze

7. KEY RECOMMENDATIONS

✔ Start with lowest effective dose (0.5 g daily)
✔ Re-evaluate need every 3-6 months (consider non-hormonal alternatives)
✔ Use vaginal moisturizers concomitantly for optimal symptom relief
✔ Monitor endometrial thickness if used >1 year (transvaginal ultrasound)

8. IMPORTANT SAFETY INFORMATION

Black Box Warnings

⚠ Endometrial Cancer Risk:

Unopposed estrogen increases risk (add progestogen if uterus present)
Monitor for abnormal bleeding

⚠ Cardiovascular/Thromboembolic Risks:

Lower than oral estrogens but still present

Contraindications

❌ Undiagnosed vaginal bleeding
❌ Estrogen-dependent neoplasia
❌ Active arterial thromboembolism
❌ Pregnancy (Category X)

Adverse Effects

Common (≥5%)	Serious (<1%)
Vaginal spotting	Endometrial hyperplasia
Breast tenderness	Venous thromboembolism
Headache	Gallbladder disease

9. COMPARISON WITH OTHER VAGINAL ESTROGENS

Parameter	Premarin Cream	Estradiol Tablet	Vaginal Ring
Estrogen Type	Conjugated	17β-estradiol	Estradiol acetate
Dosing Frequency	2-3× weekly	Daily	Every 3 months
Systemic Absorption	Low	Very low	Low
Cost/Month	$$	$	$$$

10. PATIENT COUNSELING POINTS

✔ Proper applicator cleaning (wash with mild soap after use)
✔ Expected timeline for improvement (full effects in 1-3 months)
✔ Warning signs to report:

New breast lumps
Severe headaches
Visual changes
Leg pain/swelling

✔ Alternate options:

Non-hormonal moisturizers (e.g., Replens)
Regular sexual activity to maintain blood flow

CONCLUSION

Reviews

There are no reviews yet.

Be the first to review “PREMARIN VAGINAL CREAM”

Description
Reviews (0)

Brand Name: Premarin Vaginal Cream
Generic Name: Conjugated Estrogens (USP)
Therapeutic Class: Topical Estrogen Therapy
Formulation: 0.625 mg conjugated estrogens per gram of cream
Delivery System: Graduated applicator for precise dosing

2. COMPOSITION

Component	Concentration	Purpose
Conjugated Estrogens (USP)	0.625 mg/g	Active ingredient
Cetyl Esters Wax	7%	Emollient base
Glycerin	5%	Humectant
Propylene Glycol	3%	Solvent/Preservative
Methylparaben	0.18%	Preservative

3. MECHANISM OF ACTION

Local estrogenic effects on vaginal epithelium:
- Restores vaginal pH (↓ from ~6.0 to ~4.5)
- Increases blood flow to urogenital tissues
- Thickens vaginal epithelium (maturation index improvement)
- Enhances cervical mucus production
Minimal systemic absorption:
- Serum estradiol levels typically remain in postmenopausal range
- First-pass hepatic metabolism avoided

4. DOSAGE & ADMINISTRATION

Standard Dosing Schedule

Phase	Dose (g)	Estrogen Content	Frequency	Duration
Initial	0.5-2 g	0.31-1.25 mg	Daily	2-4 weeks
Maintenance	0.5-1 g	0.31-0.625 mg	2-3× weekly	Ongoing

Administration Guide

Wash hands before application
Fill applicator to prescribed dose marking
Insert deeply into vagina (best at bedtime)
Avoid intercourse for 1 hour post-application

5. INDICATIONS

✅ Moderate-to-severe dyspareunia due to menopause
✅ Vaginal dryness/itching/burning (vulvovaginal atrophy)
✅ Urinary symptoms (dysuria, urgency) from urogenital atrophy
✅ Pre-procedure preparation for postmenopausal pelvic surgery

6. STORAGE CONDITIONS

Temperature: 20-25°C (68-77°F)
Post-Opening: Use within 3 months
Protection: Keep tube tightly closed
Do not freeze

7. KEY RECOMMENDATIONS

✔ Start with lowest effective dose (0.5 g daily)
✔ Re-evaluate need every 3-6 months (consider non-hormonal alternatives)
✔ Use vaginal moisturizers concomitantly for optimal symptom relief
✔ Monitor endometrial thickness if used >1 year (transvaginal ultrasound)

8. IMPORTANT SAFETY INFORMATION

Black Box Warnings

⚠ Endometrial Cancer Risk:

Unopposed estrogen increases risk (add progestogen if uterus present)
Monitor for abnormal bleeding

⚠ Cardiovascular/Thromboembolic Risks:

Lower than oral estrogens but still present

Contraindications

❌ Undiagnosed vaginal bleeding
❌ Estrogen-dependent neoplasia
❌ Active arterial thromboembolism
❌ Pregnancy (Category X)

Adverse Effects

Common (≥5%)	Serious (<1%)
Vaginal spotting	Endometrial hyperplasia
Breast tenderness	Venous thromboembolism
Headache	Gallbladder disease

9. COMPARISON WITH OTHER VAGINAL ESTROGENS

Parameter	Premarin Cream	Estradiol Tablet	Vaginal Ring
Estrogen Type	Conjugated	17β-estradiol	Estradiol acetate
Dosing Frequency	2-3× weekly	Daily	Every 3 months
Systemic Absorption	Low	Very low	Low
Cost/Month	$$	$	$$$

10. PATIENT COUNSELING POINTS

✔ Proper applicator cleaning (wash with mild soap after use)
✔ Expected timeline for improvement (full effects in 1-3 months)
✔ Warning signs to report:

New breast lumps
Severe headaches
Visual changes
Leg pain/swelling

✔ Alternate options:

Non-hormonal moisturizers (e.g., Replens)
Regular sexual activity to maintain blood flow

CONCLUSION

Reviews

There are no reviews yet.

Be the first to review “PREMARIN VAGINAL CREAM”

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