CABERLIN

Women Health

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Brand Name: Caberlin
Generic Name: Cabergoline
Therapeutic Class: Ergot-derived dopamine D2 receptor agonist
Dosage Form: 0.5 mg scored tablets
Key Feature:
- Long half-life (63-69 hours) → twice-weekly dosing
- Highly selective for pituitary lactotrophs

2. COMPOSITION

Component	Role
Cabergoline	Active ingredient
Lactose monohydrate	Filler
Leucine	Flow agent

(Contains ergot alkaloid derivative – monitor for fibrosis risk)

3. MECHANISM OF ACTION

✔ Inhibits prolactin secretion via:

Direct D2 receptor stimulation on lactotrophs
Downregulation of prolactin gene expression ✔ Additional Effects:
Mild GH suppression (useful in acromegaly adjunct therapy)
Parkinsonian symptom relief (high doses)

4. DOSAGE & ADMINISTRATION

By Indication

Condition	Starting Dose	Maintenance Dose	Max Dose
Hyperprolactinemia	0.25 mg 2x/week	0.5-1 mg 2x/week	4.5 mg/week
Parkinson’s Disease	0.5 mg daily	2-3 mg/day in divided doses	6 mg/day

Key Notes:

Take with food to reduce nausea
Titrate slowly (increase every 4 weeks for prolactin disorders)
For macroprolactinomas: Start low (0.25 mg/week) to avoid tumor shrinkage complications

5. INDICATIONS

✅ Hyperprolactinemic disorders:

Prolactinomas (micro/macro)
Idiopathic hyperprolactinemia
Medication-induced (e.g., antipsychotics)

✅ Parkinson’s disease (2nd line) ✅ Acromegaly adjunct therapy ✅ Infertility with hyperprolactinemia

6. STORAGE CONDITIONS

Temperature: Below 30°C
Humidity: Keep in original blister
Light Protection: Required
Shelf Life: 2-3 years

7. KEY RECOMMENDATIONS

✔ Monitoring Protocol:

Prolactin levels every 4-6 weeks until normalized
MRI for macroprolactinomas (3-6 months post-initiation)
Echocardiogram baseline + annually (fibrosis risk)

✔ For Antipsychotic-Induced Hyperprolactinemia:

Coordinate with psychiatrist
Consider alternative antipsychotics (e.g., aripiprazole) first

✔ In Pregnancy:

Discontinue once pregnancy confirmed
Monitor for tumor growth in macroprolactinomas

8. IMPORTANT SAFETY NOTES

Black Box Warnings

⚠ Valvular Heart Disease:

Risk increases with cumulative dose (>3 mg/day for Parkinson’s)
Contraindicated in fibrotic cardiac/retroperitoneal disorders

Contraindications

❌ Uncontrolled hypertension ❌ History of pericardial/pleural fibrosis ❌ Hypersensitivity to ergot derivatives

Adverse Effects

Common (≥10%)	Serious (<1%)
Nausea	Valvulopathy
Headache	Psychosis
Dizziness	Pulmonary fibrosis

9. COMPARISON WITH OTHER DOPAMINE AGONISTS

Parameter	Cabergoline	Bromocriptine	Quinagolide
Dosing Frequency	2x/week	Daily	Daily
GI Tolerance	Better	Poor	Moderate
Fibrosis Risk	Higher	Lower	Moderate
Cost	$$	$	$$$

10. PATIENT COUNSELING

✔ Take evening doses to minimize dizziness ✔ Report immediately:

Shortness of breath (cardiac fibrosis)
Hallucinations (especially in Parkinson’s patients)
Leg swelling/pain (DVT risk)

✔ Fertility patients:

May resume menses within 4-6 weeks
Use contraception until prolactin normalized

CONCLUSION

Caberlin 0.5 mg is the most potent/longest-acting prolactin-lowering agent, ideal for:

Rapid prolactin normalization
Macroprolactinoma shrinkage
Patients intolerant to bromocriptine

Brand Name: Caberlin
Generic Name: Cabergoline
Therapeutic Class: Ergot-derived dopamine D2 receptor agonist
Dosage Form: 0.5 mg scored tablets
Key Feature:
- Long half-life (63-69 hours) → twice-weekly dosing
- Highly selective for pituitary lactotrophs

2. COMPOSITION

Component	Role
Cabergoline	Active ingredient
Lactose monohydrate	Filler
Leucine	Flow agent

(Contains ergot alkaloid derivative – monitor for fibrosis risk)

3. MECHANISM OF ACTION

✔ Inhibits prolactin secretion via:

Direct D2 receptor stimulation on lactotrophs
Downregulation of prolactin gene expression
✔ Additional Effects:
Mild GH suppression (useful in acromegaly adjunct therapy)
Parkinsonian symptom relief (high doses)

4. DOSAGE & ADMINISTRATION

By Indication

Condition	Starting Dose	Maintenance Dose	Max Dose
Hyperprolactinemia	0.25 mg 2x/week	0.5-1 mg 2x/week	4.5 mg/week
Parkinson’s Disease	0.5 mg daily	2-3 mg/day in divided doses	6 mg/day

Key Notes:

Take with food to reduce nausea
Titrate slowly (increase every 4 weeks for prolactin disorders)
For macroprolactinomas: Start low (0.25 mg/week) to avoid tumor shrinkage complications

5. INDICATIONS

✅ Hyperprolactinemic disorders:

Prolactinomas (micro/macro)
Idiopathic hyperprolactinemia
Medication-induced (e.g., antipsychotics)

✅ Parkinson’s disease (2nd line)
✅ Acromegaly adjunct therapy
✅ Infertility with hyperprolactinemia

6. STORAGE CONDITIONS

Temperature: Below 30°C
Humidity: Keep in original blister
Light Protection: Required
Shelf Life: 2-3 years

7. KEY RECOMMENDATIONS

✔ Monitoring Protocol:

Prolactin levels every 4-6 weeks until normalized
MRI for macroprolactinomas (3-6 months post-initiation)
Echocardiogram baseline + annually (fibrosis risk)

✔ For Antipsychotic-Induced Hyperprolactinemia:

Coordinate with psychiatrist
Consider alternative antipsychotics (e.g., aripiprazole) first

✔ In Pregnancy:

Discontinue once pregnancy confirmed
Monitor for tumor growth in macroprolactinomas

8. IMPORTANT SAFETY NOTES

Black Box Warnings

⚠ Valvular Heart Disease:

Risk increases with cumulative dose (>3 mg/day for Parkinson’s)
Contraindicated in fibrotic cardiac/retroperitoneal disorders

Contraindications

❌ Uncontrolled hypertension
❌ History of pericardial/pleural fibrosis
❌ Hypersensitivity to ergot derivatives

Adverse Effects

Common (≥10%)	Serious (<1%)
Nausea	Valvulopathy
Headache	Psychosis
Dizziness	Pulmonary fibrosis

9. COMPARISON WITH OTHER DOPAMINE AGONISTS

Parameter	Cabergoline	Bromocriptine	Quinagolide
Dosing Frequency	2x/week	Daily	Daily
GI Tolerance	Better	Poor	Moderate
Fibrosis Risk	Higher	Lower	Moderate
Cost	$$	$	$$$

10. PATIENT COUNSELING

✔ Take evening doses to minimize dizziness
✔ Report immediately:

Shortness of breath (cardiac fibrosis)
Hallucinations (especially in Parkinson’s patients)
Leg swelling/pain (DVT risk)

✔ Fertility patients:

May resume menses within 4-6 weeks
Use contraception until prolactin normalized

CONCLUSION

Caberlin 0.5 mg is the most potent/longest-acting prolactin-lowering agent, ideal for:

Rapid prolactin normalization
Macroprolactinoma shrinkage
Patients intolerant to bromocriptine

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Brand Name: Caberlin
Generic Name: Cabergoline
Therapeutic Class: Ergot-derived dopamine D2 receptor agonist
Dosage Form: 0.5 mg scored tablets
Key Feature:
- Long half-life (63-69 hours) → twice-weekly dosing
- Highly selective for pituitary lactotrophs

2. COMPOSITION

Component	Role
Cabergoline	Active ingredient
Lactose monohydrate	Filler
Leucine	Flow agent

(Contains ergot alkaloid derivative – monitor for fibrosis risk)

3. MECHANISM OF ACTION

✔ Inhibits prolactin secretion via:

Direct D2 receptor stimulation on lactotrophs
Downregulation of prolactin gene expression
✔ Additional Effects:
Mild GH suppression (useful in acromegaly adjunct therapy)
Parkinsonian symptom relief (high doses)

4. DOSAGE & ADMINISTRATION

By Indication

Condition	Starting Dose	Maintenance Dose	Max Dose
Hyperprolactinemia	0.25 mg 2x/week	0.5-1 mg 2x/week	4.5 mg/week
Parkinson’s Disease	0.5 mg daily	2-3 mg/day in divided doses	6 mg/day

Key Notes:

Take with food to reduce nausea
Titrate slowly (increase every 4 weeks for prolactin disorders)
For macroprolactinomas: Start low (0.25 mg/week) to avoid tumor shrinkage complications

5. INDICATIONS

✅ Hyperprolactinemic disorders:

Prolactinomas (micro/macro)
Idiopathic hyperprolactinemia
Medication-induced (e.g., antipsychotics)

✅ Parkinson’s disease (2nd line)
✅ Acromegaly adjunct therapy
✅ Infertility with hyperprolactinemia

6. STORAGE CONDITIONS

Temperature: Below 30°C
Humidity: Keep in original blister
Light Protection: Required
Shelf Life: 2-3 years

7. KEY RECOMMENDATIONS

✔ Monitoring Protocol:

Prolactin levels every 4-6 weeks until normalized
MRI for macroprolactinomas (3-6 months post-initiation)
Echocardiogram baseline + annually (fibrosis risk)

✔ For Antipsychotic-Induced Hyperprolactinemia:

Coordinate with psychiatrist
Consider alternative antipsychotics (e.g., aripiprazole) first

✔ In Pregnancy:

Discontinue once pregnancy confirmed
Monitor for tumor growth in macroprolactinomas

8. IMPORTANT SAFETY NOTES

Black Box Warnings

⚠ Valvular Heart Disease:

Risk increases with cumulative dose (>3 mg/day for Parkinson’s)
Contraindicated in fibrotic cardiac/retroperitoneal disorders

Contraindications

❌ Uncontrolled hypertension
❌ History of pericardial/pleural fibrosis
❌ Hypersensitivity to ergot derivatives

Adverse Effects

Common (≥10%)	Serious (<1%)
Nausea	Valvulopathy
Headache	Psychosis
Dizziness	Pulmonary fibrosis

9. COMPARISON WITH OTHER DOPAMINE AGONISTS

Parameter	Cabergoline	Bromocriptine	Quinagolide
Dosing Frequency	2x/week	Daily	Daily
GI Tolerance	Better	Poor	Moderate
Fibrosis Risk	Higher	Lower	Moderate
Cost	$$	$	$$$

10. PATIENT COUNSELING

✔ Take evening doses to minimize dizziness
✔ Report immediately:

Shortness of breath (cardiac fibrosis)
Hallucinations (especially in Parkinson’s patients)
Leg swelling/pain (DVT risk)

✔ Fertility patients:

May resume menses within 4-6 weeks
Use contraception until prolactin normalized

CONCLUSION

Caberlin 0.5 mg is the most potent/longest-acting prolactin-lowering agent, ideal for:

Rapid prolactin normalization
Macroprolactinoma shrinkage
Patients intolerant to bromocriptine

Reviews

There are no reviews yet.

Be the first to review “CABERLIN”

Description
Reviews (0)

Brand Name: Caberlin
Generic Name: Cabergoline
Therapeutic Class: Ergot-derived dopamine D2 receptor agonist
Dosage Form: 0.5 mg scored tablets
Key Feature:
- Long half-life (63-69 hours) → twice-weekly dosing
- Highly selective for pituitary lactotrophs

2. COMPOSITION

Component	Role
Cabergoline	Active ingredient
Lactose monohydrate	Filler
Leucine	Flow agent

(Contains ergot alkaloid derivative – monitor for fibrosis risk)

3. MECHANISM OF ACTION

✔ Inhibits prolactin secretion via:

Direct D2 receptor stimulation on lactotrophs
Downregulation of prolactin gene expression
✔ Additional Effects:
Mild GH suppression (useful in acromegaly adjunct therapy)
Parkinsonian symptom relief (high doses)

4. DOSAGE & ADMINISTRATION

By Indication

Condition	Starting Dose	Maintenance Dose	Max Dose
Hyperprolactinemia	0.25 mg 2x/week	0.5-1 mg 2x/week	4.5 mg/week
Parkinson’s Disease	0.5 mg daily	2-3 mg/day in divided doses	6 mg/day

Key Notes:

Take with food to reduce nausea
Titrate slowly (increase every 4 weeks for prolactin disorders)
For macroprolactinomas: Start low (0.25 mg/week) to avoid tumor shrinkage complications

5. INDICATIONS

✅ Hyperprolactinemic disorders:

Prolactinomas (micro/macro)
Idiopathic hyperprolactinemia
Medication-induced (e.g., antipsychotics)

✅ Parkinson’s disease (2nd line)
✅ Acromegaly adjunct therapy
✅ Infertility with hyperprolactinemia

6. STORAGE CONDITIONS

Temperature: Below 30°C
Humidity: Keep in original blister
Light Protection: Required
Shelf Life: 2-3 years

7. KEY RECOMMENDATIONS

✔ Monitoring Protocol:

Prolactin levels every 4-6 weeks until normalized
MRI for macroprolactinomas (3-6 months post-initiation)
Echocardiogram baseline + annually (fibrosis risk)

✔ For Antipsychotic-Induced Hyperprolactinemia:

Coordinate with psychiatrist
Consider alternative antipsychotics (e.g., aripiprazole) first

✔ In Pregnancy:

Discontinue once pregnancy confirmed
Monitor for tumor growth in macroprolactinomas

8. IMPORTANT SAFETY NOTES

Black Box Warnings

⚠ Valvular Heart Disease:

Risk increases with cumulative dose (>3 mg/day for Parkinson’s)
Contraindicated in fibrotic cardiac/retroperitoneal disorders

Contraindications

❌ Uncontrolled hypertension
❌ History of pericardial/pleural fibrosis
❌ Hypersensitivity to ergot derivatives

Adverse Effects

Common (≥10%)	Serious (<1%)
Nausea	Valvulopathy
Headache	Psychosis
Dizziness	Pulmonary fibrosis

9. COMPARISON WITH OTHER DOPAMINE AGONISTS

Parameter	Cabergoline	Bromocriptine	Quinagolide
Dosing Frequency	2x/week	Daily	Daily
GI Tolerance	Better	Poor	Moderate
Fibrosis Risk	Higher	Lower	Moderate
Cost	$$	$	$$$

10. PATIENT COUNSELING

✔ Take evening doses to minimize dizziness
✔ Report immediately:

Shortness of breath (cardiac fibrosis)
Hallucinations (especially in Parkinson’s patients)
Leg swelling/pain (DVT risk)

✔ Fertility patients:

May resume menses within 4-6 weeks
Use contraception until prolactin normalized

CONCLUSION

Caberlin 0.5 mg is the most potent/longest-acting prolactin-lowering agent, ideal for:

Rapid prolactin normalization
Macroprolactinoma shrinkage
Patients intolerant to bromocriptine

Reviews

There are no reviews yet.

Be the first to review “CABERLIN”

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