Introduction:
Microvir 500 is an antiviral medication containing Famciclovir as its active ingredient. It is a prodrug of penciclovir and is used primarily to treat infections caused by herpesviruses, including herpes zoster (shingles), genital herpes, and cold sores (herpes labialis).
Description:
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Generic Name:Â Famciclovir
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Brand Name:Â Microvir 500
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Drug Class:Â Antiviral (Nucleoside analogue)
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Mechanism of Action: Famciclovir is converted into penciclovir in the body, which inhibits viral DNA replication by competing with deoxyguanosine triphosphate, thereby stopping herpesvirus multiplication.
Therapeutic Uses:
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Herpes Zoster (Shingles):
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Reduces pain, rash duration, and complications like postherpetic neuralgia.
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Genital Herpes:
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Treats outbreaks and suppresses recurrent episodes.
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Herpes Labialis (Cold Sores):
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Shortens healing time and symptom severity.
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Immunocompromised Patients:
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Used for herpes simplex and varicella-zoster virus infections in HIV/AIDS or transplant patients.
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Dosage:
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Herpes Zoster (Shingles):
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500 mg every 8 hours for 7 days.
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Genital Herpes (Recurrent):
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1000 mg twice daily for 1 day (short-term) OR 250 mg twice daily (suppressive therapy).
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Cold Sores (Herpes Labialis):
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1500 mg as a single dose at first sign of outbreak.
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Renal Impairment:Â Dose adjustment required (lower frequency).
Side Effects:
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Common:
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Headache, nausea, dizziness, fatigue, diarrhea.
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Less Common:
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Confusion, rash, itching, elevated liver enzymes.
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Serious (Rare):
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Severe allergic reactions, kidney dysfunction, neurological effects (hallucinations, seizures).
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Importance:
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Effective in reducing viral shedding and symptom duration.
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Helps prevent recurrent herpes outbreaks.
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Critical for immunocompromised patients to avoid complications.
Storage:
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Store at room temperature (15–30°C).
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Keep in a dry place, away from light and moisture.
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Keep out of reach of children.
Conclusion:
Microvir 500 (Famciclovir) is a potent antiviral for herpesvirus infections, offering rapid relief and suppression. Proper dosing and adherence are crucial for effectiveness, while monitoring for side effects ensures safe use.
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