Introduction:
Valgan is an antiviral medication containing Valganciclovir, a prodrug of ganciclovir. It is primarily used to treat cytomegalovirus (CMV) infections, especially in immunocompromised patients (e.g., HIV/AIDS, organ transplant recipients).
Description:
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Generic Name:Â Valganciclovir
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Brand Name:Â Valgan
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Drug Class:Â Antiviral (Nucleoside analogue)
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Mechanism of Action:
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Converts into ganciclovir, which inhibits CMV DNA polymerase, preventing viral replication.
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Therapeutic Uses:
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CMV Retinitis (in HIV Patients)
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Prevention of CMV Disease in Organ Transplant Recipients
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Kidney, heart, or pancreas transplants
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Congenital CMV Infection (in some cases)
Dosage:
Condition | Dosage | Duration |
---|---|---|
CMV Retinitis (Induction) | 900 mg twice daily | 21 days |
CMV Retinitis (Maintenance) | 900 mg once daily | Long-term |
CMV Prophylaxis (Transplant Patients) | 900 mg once daily | 100–200 days post-transplant |
Renal Dose Adjustment | Required (lower dose if impaired kidney function) | As prescribed |
Side Effects:
Common:
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Bone Marrow Suppression (↓ Neutrophils, ↓ Platelets, ↓ Hemoglobin)
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Diarrhea, nausea, vomiting
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Fever, headache, fatigue
Serious (Require Medical Attention):
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Severe neutropenia/pancytopenia (risk of infections/bleeding)
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Kidney toxicity (monitor creatinine)
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Seizures, hallucinations (CNS effects)
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Retinal detachment (in CMV retinitis patients)
Important Warnings:
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Hematologic Toxicity: Regular CBC monitoring required (risk of neutropenia, anemia, thrombocytopenia).
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Teratogenic: Contraindicated in pregnancy (Category D – can cause fetal harm).
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Carcinogenic/Mutagenic:Â Long-term use may increase cancer risk.
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Drug Interactions:
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Myelosuppressive drugs (e.g., zidovudine, trimethoprim-sulfamethoxazole) → Increased toxicity.
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Probenecid → Increases ganciclovir levels.
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Storage:
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Store at 25°C (77°F), away from moisture.
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Keep in original packaging (light-sensitive).
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Keep out of reach of children & pets.
Conclusion:
Valgan (Valganciclovir) is a potent anti-CMV drug used in immunocompromised patients. Due to its high toxicity risk, strict monitoring of blood counts and kidney function is essential.
Would you like details on pediatric dosing or alternative CMV treatments?
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