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1. Introduction

Samvec 10 mg is an oral antidiabetic medication containing saxagliptin, a DPP-4 inhibitor that enhances the body’s natural ability to control blood sugar levels. It is particularly effective for type 2 diabetes management when combined with diet and exercise.

2. Key Specifications

  • Generic Name: Saxagliptin

  • Brand Names: Samvec (India), Onglyza (international)

  • Dosage Form: Film-coated tablets (2.5 mg, 5 mg, 10 mg)

  • Manufacturer: Samarth Life Sciences

  • Drug Class: Dipeptidyl peptidase-4 (DPP-4) inhibitor

3. Therapeutic Advantages

✔ Glucose-dependent insulin secretion (low hypoglycemia risk) ✔ Weight-neutral effect ✔ Once-daily dosing for better compliance ✔ Cardiovascular safety proven in clinical trials

4. Mechanism of Action

  • Inhibits DPP-4 enzyme, prolonging active GLP-1 and GIP

  • Enhances pancreatic insulin secretion when glucose is high

  • Suppresses glucagon release from alpha cells

  • Slows gastric emptying (mild effect)

5. Approved Indications

  • Type 2 diabetes mellitus (monotherapy or combination)

  • Adjunct to diet and exercise

  • Combination with metformin, SGLT2 inhibitors, or insulin

6. Dosage & Administration

  • Standard Dose: 5 mg once daily (2.5 mg if CrCl ≤50 mL/min)

  • Maximum Dose: 5 mg daily (10 mg not commonly used)

  • Best Taken: Morning, with/without food

  • Missed Dose: Take if remembered same day; skip if next day

7. Side Effects

Common (≥1%):

  • Upper respiratory tract infection

  • Urinary tract infection

  • Headache

Serious (Monitor For):

  • Pancreatitis (rare but serious)

  • Hypersensitivity reactions

  • Joint pain (severe arthralgia)

  • Heart failure (in predisposed patients)

8. Pharmacokinetics

  • Peak Time: 2 hours

  • Half-life: 2.5-3.5 hours

  • Duration: 24 hours (DPP-4 inhibition)

  • Metabolism: CYP3A4/5 mediated

  • Excretion: Renal (75%) and fecal (22%)

9. Storage Requirements

  • Temperature: Below 30°C

  • Humidity: Keep in original packaging

  • Stability: 24 months from manufacture

10. Important Precautions

⚠ Renal Impairment:

  • CrCl >50: 5 mg daily

  • CrCl ≤50: 2.5 mg daily

  • ESRD: Not recommended

⚠ Hepatic Impairment:

  • No dose adjustment needed

⚠ Drug Interactions:

  • Strong CYP3A4 inhibitors (ketoconazole): Reduce to 2.5 mg

  • CYP3A4 inducers (rifampin): May need dose increase

11. Clinical Advantages Over Other DPP-4 Inhibitors

Parameter Saxagliptin Sitagliptin Linagliptin
Renal Adjustment Yes Yes No
CYP Interactions Yes Minimal Minimal
CV Outcome Neutral Neutral Neutral
Cost Moderate High High

12. Patient Counseling Points

• “Take at the same time daily” • “Report unusual stomach pain immediately” • “Monitor for signs of heart failure” • “Continue diet/exercise regimen”

13. Conclusion

Samvec 10 mg offers effective glycemic control with minimal side effects, making it a valuable option for type 2 diabetes management. While the 10 mg dose exists, 5 mg is typically the maintenance dose, with 10 mg reserved for specific cases under medical supervision. Its once-daily regimen and weight-neutral profile enhance patient compliance.

1. Introduction

Samvec 10 mg is an oral antidiabetic medication containing saxagliptin, a DPP-4 inhibitor that enhances the body’s natural ability to control blood sugar levels. It is particularly effective for type 2 diabetes management when combined with diet and exercise.

2. Key Specifications

  • Generic Name: Saxagliptin

  • Brand Names: Samvec (India), Onglyza (international)

  • Dosage Form: Film-coated tablets (2.5 mg, 5 mg, 10 mg)

  • Manufacturer: Samarth Life Sciences

  • Drug Class: Dipeptidyl peptidase-4 (DPP-4) inhibitor

3. Therapeutic Advantages

✔ Glucose-dependent insulin secretion (low hypoglycemia risk)
✔ Weight-neutral effect
✔ Once-daily dosing for better compliance
✔ Cardiovascular safety proven in clinical trials

4. Mechanism of Action

  • Inhibits DPP-4 enzyme, prolonging active GLP-1 and GIP

  • Enhances pancreatic insulin secretion when glucose is high

  • Suppresses glucagon release from alpha cells

  • Slows gastric emptying (mild effect)

5. Approved Indications

  • Type 2 diabetes mellitus (monotherapy or combination)

  • Adjunct to diet and exercise

  • Combination with metformin, SGLT2 inhibitors, or insulin

6. Dosage & Administration

  • Standard Dose: 5 mg once daily (2.5 mg if CrCl ≤50 mL/min)

  • Maximum Dose: 5 mg daily (10 mg not commonly used)

  • Best Taken: Morning, with/without food

  • Missed Dose: Take if remembered same day; skip if next day

7. Side Effects

Common (≥1%):

  • Upper respiratory tract infection

  • Urinary tract infection

  • Headache

Serious (Monitor For):

  • Pancreatitis (rare but serious)

  • Hypersensitivity reactions

  • Joint pain (severe arthralgia)

  • Heart failure (in predisposed patients)

8. Pharmacokinetics

  • Peak Time: 2 hours

  • Half-life: 2.5-3.5 hours

  • Duration: 24 hours (DPP-4 inhibition)

  • Metabolism: CYP3A4/5 mediated

  • Excretion: Renal (75%) and fecal (22%)

9. Storage Requirements

  • Temperature: Below 30°C

  • Humidity: Keep in original packaging

  • Stability: 24 months from manufacture

10. Important Precautions

⚠ Renal Impairment:

  • CrCl >50: 5 mg daily

  • CrCl ≤50: 2.5 mg daily

  • ESRD: Not recommended

⚠ Hepatic Impairment:

  • No dose adjustment needed

⚠ Drug Interactions:

  • Strong CYP3A4 inhibitors (ketoconazole): Reduce to 2.5 mg

  • CYP3A4 inducers (rifampin): May need dose increase

11. Clinical Advantages Over Other DPP-4 Inhibitors

Parameter Saxagliptin Sitagliptin Linagliptin
Renal Adjustment Yes Yes No
CYP Interactions Yes Minimal Minimal
CV Outcome Neutral Neutral Neutral
Cost Moderate High High

12. Patient Counseling Points

• “Take at the same time daily”
• “Report unusual stomach pain immediately”
• “Monitor for signs of heart failure”
• “Continue diet/exercise regimen”

13. Conclusion

Samvec 10 mg offers effective glycemic control with minimal side effects, making it a valuable option for type 2 diabetes management. While the 10 mg dose exists, 5 mg is typically the maintenance dose, with 10 mg reserved for specific cases under medical supervision. Its once-daily regimen and weight-neutral profile enhance patient compliance.

Shipping Options – 

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions – 

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

1. Introduction

Samvec 10 mg is an oral antidiabetic medication containing saxagliptin, a DPP-4 inhibitor that enhances the body’s natural ability to control blood sugar levels. It is particularly effective for type 2 diabetes management when combined with diet and exercise.

2. Key Specifications

  • Generic Name: Saxagliptin

  • Brand Names: Samvec (India), Onglyza (international)

  • Dosage Form: Film-coated tablets (2.5 mg, 5 mg, 10 mg)

  • Manufacturer: Samarth Life Sciences

  • Drug Class: Dipeptidyl peptidase-4 (DPP-4) inhibitor

3. Therapeutic Advantages

✔ Glucose-dependent insulin secretion (low hypoglycemia risk)
✔ Weight-neutral effect
✔ Once-daily dosing for better compliance
✔ Cardiovascular safety proven in clinical trials

4. Mechanism of Action

  • Inhibits DPP-4 enzyme, prolonging active GLP-1 and GIP

  • Enhances pancreatic insulin secretion when glucose is high

  • Suppresses glucagon release from alpha cells

  • Slows gastric emptying (mild effect)

5. Approved Indications

  • Type 2 diabetes mellitus (monotherapy or combination)

  • Adjunct to diet and exercise

  • Combination with metformin, SGLT2 inhibitors, or insulin

6. Dosage & Administration

  • Standard Dose: 5 mg once daily (2.5 mg if CrCl ≤50 mL/min)

  • Maximum Dose: 5 mg daily (10 mg not commonly used)

  • Best Taken: Morning, with/without food

  • Missed Dose: Take if remembered same day; skip if next day

7. Side Effects

Common (≥1%):

  • Upper respiratory tract infection

  • Urinary tract infection

  • Headache

Serious (Monitor For):

  • Pancreatitis (rare but serious)

  • Hypersensitivity reactions

  • Joint pain (severe arthralgia)

  • Heart failure (in predisposed patients)

8. Pharmacokinetics

  • Peak Time: 2 hours

  • Half-life: 2.5-3.5 hours

  • Duration: 24 hours (DPP-4 inhibition)

  • Metabolism: CYP3A4/5 mediated

  • Excretion: Renal (75%) and fecal (22%)

9. Storage Requirements

  • Temperature: Below 30°C

  • Humidity: Keep in original packaging

  • Stability: 24 months from manufacture

10. Important Precautions

⚠ Renal Impairment:

  • CrCl >50: 5 mg daily

  • CrCl ≤50: 2.5 mg daily

  • ESRD: Not recommended

⚠ Hepatic Impairment:

  • No dose adjustment needed

⚠ Drug Interactions:

  • Strong CYP3A4 inhibitors (ketoconazole): Reduce to 2.5 mg

  • CYP3A4 inducers (rifampin): May need dose increase

11. Clinical Advantages Over Other DPP-4 Inhibitors

Parameter Saxagliptin Sitagliptin Linagliptin
Renal Adjustment Yes Yes No
CYP Interactions Yes Minimal Minimal
CV Outcome Neutral Neutral Neutral
Cost Moderate High High

12. Patient Counseling Points

• “Take at the same time daily”
• “Report unusual stomach pain immediately”
• “Monitor for signs of heart failure”
• “Continue diet/exercise regimen”

13. Conclusion

Samvec 10 mg offers effective glycemic control with minimal side effects, making it a valuable option for type 2 diabetes management. While the 10 mg dose exists, 5 mg is typically the maintenance dose, with 10 mg reserved for specific cases under medical supervision. Its once-daily regimen and weight-neutral profile enhance patient compliance.

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1. Introduction

Samvec 10 mg is an oral antidiabetic medication containing saxagliptin, a DPP-4 inhibitor that enhances the body’s natural ability to control blood sugar levels. It is particularly effective for type 2 diabetes management when combined with diet and exercise.

2. Key Specifications

  • Generic Name: Saxagliptin

  • Brand Names: Samvec (India), Onglyza (international)

  • Dosage Form: Film-coated tablets (2.5 mg, 5 mg, 10 mg)

  • Manufacturer: Samarth Life Sciences

  • Drug Class: Dipeptidyl peptidase-4 (DPP-4) inhibitor

3. Therapeutic Advantages

✔ Glucose-dependent insulin secretion (low hypoglycemia risk)
✔ Weight-neutral effect
✔ Once-daily dosing for better compliance
✔ Cardiovascular safety proven in clinical trials

4. Mechanism of Action

  • Inhibits DPP-4 enzyme, prolonging active GLP-1 and GIP

  • Enhances pancreatic insulin secretion when glucose is high

  • Suppresses glucagon release from alpha cells

  • Slows gastric emptying (mild effect)

5. Approved Indications

  • Type 2 diabetes mellitus (monotherapy or combination)

  • Adjunct to diet and exercise

  • Combination with metformin, SGLT2 inhibitors, or insulin

6. Dosage & Administration

  • Standard Dose: 5 mg once daily (2.5 mg if CrCl ≤50 mL/min)

  • Maximum Dose: 5 mg daily (10 mg not commonly used)

  • Best Taken: Morning, with/without food

  • Missed Dose: Take if remembered same day; skip if next day

7. Side Effects

Common (≥1%):

  • Upper respiratory tract infection

  • Urinary tract infection

  • Headache

Serious (Monitor For):

  • Pancreatitis (rare but serious)

  • Hypersensitivity reactions

  • Joint pain (severe arthralgia)

  • Heart failure (in predisposed patients)

8. Pharmacokinetics

  • Peak Time: 2 hours

  • Half-life: 2.5-3.5 hours

  • Duration: 24 hours (DPP-4 inhibition)

  • Metabolism: CYP3A4/5 mediated

  • Excretion: Renal (75%) and fecal (22%)

9. Storage Requirements

  • Temperature: Below 30°C

  • Humidity: Keep in original packaging

  • Stability: 24 months from manufacture

10. Important Precautions

⚠ Renal Impairment:

  • CrCl >50: 5 mg daily

  • CrCl ≤50: 2.5 mg daily

  • ESRD: Not recommended

⚠ Hepatic Impairment:

  • No dose adjustment needed

⚠ Drug Interactions:

  • Strong CYP3A4 inhibitors (ketoconazole): Reduce to 2.5 mg

  • CYP3A4 inducers (rifampin): May need dose increase

11. Clinical Advantages Over Other DPP-4 Inhibitors

Parameter Saxagliptin Sitagliptin Linagliptin
Renal Adjustment Yes Yes No
CYP Interactions Yes Minimal Minimal
CV Outcome Neutral Neutral Neutral
Cost Moderate High High

12. Patient Counseling Points

• “Take at the same time daily”
• “Report unusual stomach pain immediately”
• “Monitor for signs of heart failure”
• “Continue diet/exercise regimen”

13. Conclusion

Samvec 10 mg offers effective glycemic control with minimal side effects, making it a valuable option for type 2 diabetes management. While the 10 mg dose exists, 5 mg is typically the maintenance dose, with 10 mg reserved for specific cases under medical supervision. Its once-daily regimen and weight-neutral profile enhance patient compliance.

Reviews

There are no reviews yet.

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Anteka Pharmacy primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on Anteka Pharmacy. Our mission is to support, not replace, the doctor-patient relationship.
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