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DESIROX 250

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1. Definition & Composition

  • Generic Name: Deferasirox

  • Dosage Form: Dispersible tablet (oral suspension preparation)

  • Strength: 250 mg per tablet

  • Class: Oral iron chelator (tridentate ligand)

  • Mechanism: Selectively binds ferric iron (Fe³⁺) forming stable complexes excreted in feces

2. Importance & Clinical Use

Primary Indications

✅ Chronic Iron Overload in:

  • Transfusion-dependent thalassemia (≥6 transfusions/year)

  • Sickle cell disease (≥8 transfusions/year)

  • Myelodysplastic syndromes (MDS)

  • Other transfusion-dependent anemias

✅ Non-Transfusion Iron Overload (e.g., hereditary hemochromatosis if intolerant to phlebotomy)

Key Benefits

  • Once-daily oral dosing (vs. subcutaneous/infusional chelators)

  • Effective iron excretion (up to 30 mg Fe/day at optimal doses)

  • Reduces liver/cardiac iron (T2* MRI improvement in 6-12 months)

3. Dosage & Administration

Dosing Guidelines

Patient Population Initial Dose Maintenance Adjustment
Transfusion-dependent 20 mg/kg/day ↑ by 5-10 mg/kg every 3-6 months (max 40 mg/kg/day)
Non-transfusion overload 10 mg/kg/day Adjust based on serum ferritin

Administration Protocol

  1. Take on empty stomach (30 min before breakfast)

  2. Disperse tablet in water/orange juice (NOT milk or antacids)

  3. Stir until fine suspension → drink immediately

  4. Avoid aluminum-containing antacids (separate by 4 hrs)

4. Side Effects & Toxicity

Common (≥10%)

  • Gastrointestinal: Nausea (35%), diarrhea (25%), abdominal pain (20%)

  • Skin Rash (15%)

  • Mild proteinuria (12%)

Serious (Require Monitoring)

  • Renal Toxicity: ↑ serum creatinine (30%), acute kidney injury

  • Hepatotoxicity: ↑ ALT/AST (10%), rare hepatic failure

  • GI Ulceration/hemorrhage (especially in elderly)

  • Auditory/Visual disturbances (high-frequency hearing loss, cataracts)

5. Storage & Handling

  • Store below 30°C in original blister packaging

  • Protect from moisture (desiccant in bottle)

  • Reconstituted suspension: Use within 30 minutes

6. Contraindications & Warnings

❌ Absolute Contraindications:

  • Severe renal impairment (CrCl <40 mL/min)

  • Advanced hepatic cirrhosis (Child-Pugh C)

  • History of GI perforation/hemorrhage

⚠️ Boxed Warnings (FDA):

  • Renal/hepatic failure (monitor creatinine/ALT weekly initially)

  • Fatal GI hemorrhage (higher risk in elderly)

7. Drug Interactions

  • Antacids/Al supplements: ↓ Deferasirox absorption

  • CYP3A4 inducers (rifampin): ↓ Efficacy

  • CYP1A2 substrates (theophylline): ↑ Toxicity risk

8. Monitoring Protocol

Parameter Frequency Action Threshold
Serum ferritin Monthly Maintain 500-1000 ng/mL
Serum creatinine Weekly ×1 month, then monthly ↑ >33% baseline → dose reduction
Liver function Monthly ALT >5× ULN → interrupt
Auditory/visual Annual exams New-onset changes → reassess

9. Cost & Alternatives

  • Price: ~$250/30 tablets (generic available)

  • Comparators:

    • Deferoxamine (IV): More potent but requires infusion

    • Deferiprone (oral): Better cardiac iron removal but ↑ agranulocytosis risk

10. Conclusion

DESIROX 250 mg is a first-line oral chelator for chronic iron overload, offering: ✔ Convenient dosing vs. parenteral alternatives ✔ Proven efficacy in reducing organ iron ✔ Flexible dose adjustments based on ferritin trends

Critical Practice Points:

  1. Strict adherence to monitoring protocols (renal/hepatic)

  2. Avoid use with NSAIDs/anticoagulants (↑ bleeding risk)

  3. Consider switching to IV chelation if poor GI tolerance

1. Definition & Composition

  • Generic Name: Deferasirox

  • Dosage Form: Dispersible tablet (oral suspension preparation)

  • Strength: 250 mg per tablet

  • Class: Oral iron chelator (tridentate ligand)

  • Mechanism: Selectively binds ferric iron (Fe³⁺) forming stable complexes excreted in feces

2. Importance & Clinical Use

Primary Indications

✅ Chronic Iron Overload in:

  • Transfusion-dependent thalassemia (≥6 transfusions/year)

  • Sickle cell disease (≥8 transfusions/year)

  • Myelodysplastic syndromes (MDS)

  • Other transfusion-dependent anemias

✅ Non-Transfusion Iron Overload (e.g., hereditary hemochromatosis if intolerant to phlebotomy)

Key Benefits

  • Once-daily oral dosing (vs. subcutaneous/infusional chelators)

  • Effective iron excretion (up to 30 mg Fe/day at optimal doses)

  • Reduces liver/cardiac iron (T2* MRI improvement in 6-12 months)

3. Dosage & Administration

Dosing Guidelines

Patient Population Initial Dose Maintenance Adjustment
Transfusion-dependent 20 mg/kg/day ↑ by 5-10 mg/kg every 3-6 months (max 40 mg/kg/day)
Non-transfusion overload 10 mg/kg/day Adjust based on serum ferritin

Administration Protocol

  1. Take on empty stomach (30 min before breakfast)

  2. Disperse tablet in water/orange juice (NOT milk or antacids)

  3. Stir until fine suspension → drink immediately

  4. Avoid aluminum-containing antacids (separate by 4 hrs)

4. Side Effects & Toxicity

Common (≥10%)

  • Gastrointestinal: Nausea (35%), diarrhea (25%), abdominal pain (20%)

  • Skin Rash (15%)

  • Mild proteinuria (12%)

Serious (Require Monitoring)

  • Renal Toxicity: ↑ serum creatinine (30%), acute kidney injury

  • Hepatotoxicity: ↑ ALT/AST (10%), rare hepatic failure

  • GI Ulceration/hemorrhage (especially in elderly)

  • Auditory/Visual disturbances (high-frequency hearing loss, cataracts)

5. Storage & Handling

  • Store below 30°C in original blister packaging

  • Protect from moisture (desiccant in bottle)

  • Reconstituted suspension: Use within 30 minutes

6. Contraindications & Warnings

❌ Absolute Contraindications:

  • Severe renal impairment (CrCl <40 mL/min)

  • Advanced hepatic cirrhosis (Child-Pugh C)

  • History of GI perforation/hemorrhage

⚠️ Boxed Warnings (FDA):

  • Renal/hepatic failure (monitor creatinine/ALT weekly initially)

  • Fatal GI hemorrhage (higher risk in elderly)

7. Drug Interactions

  • Antacids/Al supplements: ↓ Deferasirox absorption

  • CYP3A4 inducers (rifampin): ↓ Efficacy

  • CYP1A2 substrates (theophylline): ↑ Toxicity risk

8. Monitoring Protocol

Parameter Frequency Action Threshold
Serum ferritin Monthly Maintain 500-1000 ng/mL
Serum creatinine Weekly ×1 month, then monthly ↑ >33% baseline → dose reduction
Liver function Monthly ALT >5× ULN → interrupt
Auditory/visual Annual exams New-onset changes → reassess

9. Cost & Alternatives

  • Price: ~$250/30 tablets (generic available)

  • Comparators:

    • Deferoxamine (IV): More potent but requires infusion

    • Deferiprone (oral): Better cardiac iron removal but ↑ agranulocytosis risk

10. Conclusion

DESIROX 250 mg is a first-line oral chelator for chronic iron overload, offering:
✔ Convenient dosing vs. parenteral alternatives
✔ Proven efficacy in reducing organ iron
✔ Flexible dose adjustments based on ferritin trends

Critical Practice Points:

  1. Strict adherence to monitoring protocols (renal/hepatic)

  2. Avoid use with NSAIDs/anticoagulants (↑ bleeding risk)

  3. Consider switching to IV chelation if poor GI tolerance

Shipping Options – 

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions – 

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

1. Definition & Composition

  • Generic Name: Deferasirox

  • Dosage Form: Dispersible tablet (oral suspension preparation)

  • Strength: 250 mg per tablet

  • Class: Oral iron chelator (tridentate ligand)

  • Mechanism: Selectively binds ferric iron (Fe³⁺) forming stable complexes excreted in feces

2. Importance & Clinical Use

Primary Indications

✅ Chronic Iron Overload in:

  • Transfusion-dependent thalassemia (≥6 transfusions/year)

  • Sickle cell disease (≥8 transfusions/year)

  • Myelodysplastic syndromes (MDS)

  • Other transfusion-dependent anemias

✅ Non-Transfusion Iron Overload (e.g., hereditary hemochromatosis if intolerant to phlebotomy)

Key Benefits

  • Once-daily oral dosing (vs. subcutaneous/infusional chelators)

  • Effective iron excretion (up to 30 mg Fe/day at optimal doses)

  • Reduces liver/cardiac iron (T2* MRI improvement in 6-12 months)

3. Dosage & Administration

Dosing Guidelines

Patient Population Initial Dose Maintenance Adjustment
Transfusion-dependent 20 mg/kg/day ↑ by 5-10 mg/kg every 3-6 months (max 40 mg/kg/day)
Non-transfusion overload 10 mg/kg/day Adjust based on serum ferritin

Administration Protocol

  1. Take on empty stomach (30 min before breakfast)

  2. Disperse tablet in water/orange juice (NOT milk or antacids)

  3. Stir until fine suspension → drink immediately

  4. Avoid aluminum-containing antacids (separate by 4 hrs)

4. Side Effects & Toxicity

Common (≥10%)

  • Gastrointestinal: Nausea (35%), diarrhea (25%), abdominal pain (20%)

  • Skin Rash (15%)

  • Mild proteinuria (12%)

Serious (Require Monitoring)

  • Renal Toxicity: ↑ serum creatinine (30%), acute kidney injury

  • Hepatotoxicity: ↑ ALT/AST (10%), rare hepatic failure

  • GI Ulceration/hemorrhage (especially in elderly)

  • Auditory/Visual disturbances (high-frequency hearing loss, cataracts)

5. Storage & Handling

  • Store below 30°C in original blister packaging

  • Protect from moisture (desiccant in bottle)

  • Reconstituted suspension: Use within 30 minutes

6. Contraindications & Warnings

❌ Absolute Contraindications:

  • Severe renal impairment (CrCl <40 mL/min)

  • Advanced hepatic cirrhosis (Child-Pugh C)

  • History of GI perforation/hemorrhage

⚠️ Boxed Warnings (FDA):

  • Renal/hepatic failure (monitor creatinine/ALT weekly initially)

  • Fatal GI hemorrhage (higher risk in elderly)

7. Drug Interactions

  • Antacids/Al supplements: ↓ Deferasirox absorption

  • CYP3A4 inducers (rifampin): ↓ Efficacy

  • CYP1A2 substrates (theophylline): ↑ Toxicity risk

8. Monitoring Protocol

Parameter Frequency Action Threshold
Serum ferritin Monthly Maintain 500-1000 ng/mL
Serum creatinine Weekly ×1 month, then monthly ↑ >33% baseline → dose reduction
Liver function Monthly ALT >5× ULN → interrupt
Auditory/visual Annual exams New-onset changes → reassess

9. Cost & Alternatives

  • Price: ~$250/30 tablets (generic available)

  • Comparators:

    • Deferoxamine (IV): More potent but requires infusion

    • Deferiprone (oral): Better cardiac iron removal but ↑ agranulocytosis risk

10. Conclusion

DESIROX 250 mg is a first-line oral chelator for chronic iron overload, offering:
✔ Convenient dosing vs. parenteral alternatives
✔ Proven efficacy in reducing organ iron
✔ Flexible dose adjustments based on ferritin trends

Critical Practice Points:

  1. Strict adherence to monitoring protocols (renal/hepatic)

  2. Avoid use with NSAIDs/anticoagulants (↑ bleeding risk)

  3. Consider switching to IV chelation if poor GI tolerance

Reviews

There are no reviews yet.

Be the first to review “DESIROX 250”

Your email address will not be published. Required fields are marked *

1. Definition & Composition

  • Generic Name: Deferasirox

  • Dosage Form: Dispersible tablet (oral suspension preparation)

  • Strength: 250 mg per tablet

  • Class: Oral iron chelator (tridentate ligand)

  • Mechanism: Selectively binds ferric iron (Fe³⁺) forming stable complexes excreted in feces

2. Importance & Clinical Use

Primary Indications

✅ Chronic Iron Overload in:

  • Transfusion-dependent thalassemia (≥6 transfusions/year)

  • Sickle cell disease (≥8 transfusions/year)

  • Myelodysplastic syndromes (MDS)

  • Other transfusion-dependent anemias

✅ Non-Transfusion Iron Overload (e.g., hereditary hemochromatosis if intolerant to phlebotomy)

Key Benefits

  • Once-daily oral dosing (vs. subcutaneous/infusional chelators)

  • Effective iron excretion (up to 30 mg Fe/day at optimal doses)

  • Reduces liver/cardiac iron (T2* MRI improvement in 6-12 months)

3. Dosage & Administration

Dosing Guidelines

Patient Population Initial Dose Maintenance Adjustment
Transfusion-dependent 20 mg/kg/day ↑ by 5-10 mg/kg every 3-6 months (max 40 mg/kg/day)
Non-transfusion overload 10 mg/kg/day Adjust based on serum ferritin

Administration Protocol

  1. Take on empty stomach (30 min before breakfast)

  2. Disperse tablet in water/orange juice (NOT milk or antacids)

  3. Stir until fine suspension → drink immediately

  4. Avoid aluminum-containing antacids (separate by 4 hrs)

4. Side Effects & Toxicity

Common (≥10%)

  • Gastrointestinal: Nausea (35%), diarrhea (25%), abdominal pain (20%)

  • Skin Rash (15%)

  • Mild proteinuria (12%)

Serious (Require Monitoring)

  • Renal Toxicity: ↑ serum creatinine (30%), acute kidney injury

  • Hepatotoxicity: ↑ ALT/AST (10%), rare hepatic failure

  • GI Ulceration/hemorrhage (especially in elderly)

  • Auditory/Visual disturbances (high-frequency hearing loss, cataracts)

5. Storage & Handling

  • Store below 30°C in original blister packaging

  • Protect from moisture (desiccant in bottle)

  • Reconstituted suspension: Use within 30 minutes

6. Contraindications & Warnings

❌ Absolute Contraindications:

  • Severe renal impairment (CrCl <40 mL/min)

  • Advanced hepatic cirrhosis (Child-Pugh C)

  • History of GI perforation/hemorrhage

⚠️ Boxed Warnings (FDA):

  • Renal/hepatic failure (monitor creatinine/ALT weekly initially)

  • Fatal GI hemorrhage (higher risk in elderly)

7. Drug Interactions

  • Antacids/Al supplements: ↓ Deferasirox absorption

  • CYP3A4 inducers (rifampin): ↓ Efficacy

  • CYP1A2 substrates (theophylline): ↑ Toxicity risk

8. Monitoring Protocol

Parameter Frequency Action Threshold
Serum ferritin Monthly Maintain 500-1000 ng/mL
Serum creatinine Weekly ×1 month, then monthly ↑ >33% baseline → dose reduction
Liver function Monthly ALT >5× ULN → interrupt
Auditory/visual Annual exams New-onset changes → reassess

9. Cost & Alternatives

  • Price: ~$250/30 tablets (generic available)

  • Comparators:

    • Deferoxamine (IV): More potent but requires infusion

    • Deferiprone (oral): Better cardiac iron removal but ↑ agranulocytosis risk

10. Conclusion

DESIROX 250 mg is a first-line oral chelator for chronic iron overload, offering:
✔ Convenient dosing vs. parenteral alternatives
✔ Proven efficacy in reducing organ iron
✔ Flexible dose adjustments based on ferritin trends

Critical Practice Points:

  1. Strict adherence to monitoring protocols (renal/hepatic)

  2. Avoid use with NSAIDs/anticoagulants (↑ bleeding risk)

  3. Consider switching to IV chelation if poor GI tolerance

Reviews

There are no reviews yet.

Be the first to review “DESIROX 250”

Your email address will not be published. Required fields are marked *

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Anteka Pharmacy primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on Anteka Pharmacy. Our mission is to support, not replace, the doctor-patient relationship.
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