REVOLADE 50MG

Anemia

Description
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1. Definition & Mechanism

Generic Name: Eltrombopag
Brand Name: Revolade (also marketed as Promacta in some regions)
Class: Thrombopoietin receptor agonist (TPO-RA) (oral small-molecule)
Mechanism: Binds to the TPO receptor on megakaryocytes → stimulates platelet production
Half-life: ~21–32 hours (allows once-daily dosing)

2. Indications & Importance

✅ FDA/EMA-Approved Uses:

Chronic Immune Thrombocytopenia (ITP) (adults & children ≥1 year) – 2nd-line therapy
Severe Aplastic Anemia (SAA) (in combination with immunosuppressants)
Hepatitis C-associated Thrombocytopenia (to permit antiviral therapy)
Chemotherapy-Induced Thrombocytopenia (under investigation)

⚠️ Not for use in:

Myelodysplastic syndromes (MDS) (↑ risk of leukemic progression)
Patients with normal platelet counts

3. Dosage & Administration

Standard Dosing Guidelines

Indication	Starting Dose	Dose Adjustment	Max Dose
ITP (Adults)	50 mg once daily	Adjust by 25 mg every 2 weeks	75 mg/day
ITP (Children 1-5 yrs)	25 mg once daily	Adjust by 12.5–25 mg	75 mg/day
SAA	150 mg once daily	Reduce if platelets >200,000/μL	150 mg/day
HCV Thrombocytopenia	25 mg once daily	Titrate weekly	100 mg/day

Key Administration Points:

Take on an empty stomach (1 hr before or 2 hrs after food)
Avoid calcium-rich foods/drugs (dairy, antacids – separate by ≥4 hrs)
Do not crush tablets (film-coated)

4. Side Effects & Toxicity

Common (≥10%)

Headache (20%)
Nausea, diarrhea (15%)
Fatigue (12%)
Mild liver enzyme elevation (ALT/AST ↑)

Serious (Monitor Closely)

Hepatotoxicity (rare but severe)
Thrombosis (arterial/venous – especially if platelets >400,000/μL)
Bone Marrow Fibrosis (long-term use)
Cataracts (ophthalmic exams recommended)

5. Storage & Handling

Store at 20–25°C (room temperature)
Keep in original blister pack (protects from moisture)
Do not freeze

6. Contraindications & Warnings

❌ Absolute Contraindications:

Hypersensitivity to eltrombopag
Severe hepatic impairment (Child-Pugh C)
Active thrombosis

⚠️ Black Box Warnings (FDA):

Risk of hepatotoxicity (monitor LFTs every 2 weeks initially)
Risk of bone marrow fibrosis (check reticulin staining if long-term use)

7. Drug Interactions

Polyvalent cations (Ca²⁺, Mg²⁺, Fe²⁺): ↓ Absorption (separate doses by 4 hrs)
CYP1A2/CYP2C8 inhibitors (fluvoxamine, gemfibrozil): ↑ Eltrombopag levels
Statins: May ↑ risk of myopathy

8. Monitoring Requirements

Parameter	Frequency	Action Threshold
Platelet count	Weekly until stable, then monthly	>150,000/μL → reduce dose
Liver enzymes	Every 2 weeks ×3 months, then monthly	ALT >3× ULN → interrupt
Bone marrow biopsy	Annually (if long-term use)	Reticulin fibrosis → reconsider therapy

9. Cost & Alternatives

Price: ~$5,000–$7,000/month (brand)
Alternatives:
- Romiplostim (Nplate) (subcutaneous TPO-RA)
- Avatrombopag (Doptelet) (alternative oral TPO-RA)

10. Conclusion

REVOLADE 50 mg is a potent oral thrombopoietin agonist for ITP, SAA, and HCV-related thrombocytopenia.

Key Takeaways:

✔ Effective in refractory ITP (60–80% response rate) ✔ Convenient oral dosing (vs. injectable alternatives) ✔ Requires strict monitoring (liver, platelets, bone marrow)

Clinical Pearls:

Start low, go slow (especially in elderly)
Discontinue if no response after 4 weeks
Consider thromboprophylaxis if platelets >400,000/μL

1. Definition & Mechanism

Generic Name: Eltrombopag
Brand Name: Revolade (also marketed as Promacta in some regions)
Class: Thrombopoietin receptor agonist (TPO-RA) (oral small-molecule)
Mechanism: Binds to the TPO receptor on megakaryocytes → stimulates platelet production
Half-life: ~21–32 hours (allows once-daily dosing)

2. Indications & Importance

✅ FDA/EMA-Approved Uses:

Chronic Immune Thrombocytopenia (ITP) (adults & children ≥1 year) – 2nd-line therapy
Severe Aplastic Anemia (SAA) (in combination with immunosuppressants)
Hepatitis C-associated Thrombocytopenia (to permit antiviral therapy)
Chemotherapy-Induced Thrombocytopenia (under investigation)

⚠️ Not for use in:

Myelodysplastic syndromes (MDS) (↑ risk of leukemic progression)
Patients with normal platelet counts

3. Dosage & Administration

Standard Dosing Guidelines

Indication	Starting Dose	Dose Adjustment	Max Dose
ITP (Adults)	50 mg once daily	Adjust by 25 mg every 2 weeks	75 mg/day
ITP (Children 1-5 yrs)	25 mg once daily	Adjust by 12.5–25 mg	75 mg/day
SAA	150 mg once daily	Reduce if platelets >200,000/μL	150 mg/day
HCV Thrombocytopenia	25 mg once daily	Titrate weekly	100 mg/day

Key Administration Points:

Take on an empty stomach (1 hr before or 2 hrs after food)
Avoid calcium-rich foods/drugs (dairy, antacids – separate by ≥4 hrs)
Do not crush tablets (film-coated)

4. Side Effects & Toxicity

Common (≥10%)

Headache (20%)
Nausea, diarrhea (15%)
Fatigue (12%)
Mild liver enzyme elevation (ALT/AST ↑)

Serious (Monitor Closely)

Hepatotoxicity (rare but severe)
Thrombosis (arterial/venous – especially if platelets >400,000/μL)
Bone Marrow Fibrosis (long-term use)
Cataracts (ophthalmic exams recommended)

5. Storage & Handling

Store at 20–25°C (room temperature)
Keep in original blister pack (protects from moisture)
Do not freeze

6. Contraindications & Warnings

❌ Absolute Contraindications:

Hypersensitivity to eltrombopag
Severe hepatic impairment (Child-Pugh C)
Active thrombosis

⚠️ Black Box Warnings (FDA):

Risk of hepatotoxicity (monitor LFTs every 2 weeks initially)
Risk of bone marrow fibrosis (check reticulin staining if long-term use)

7. Drug Interactions

Polyvalent cations (Ca²⁺, Mg²⁺, Fe²⁺): ↓ Absorption (separate doses by 4 hrs)
CYP1A2/CYP2C8 inhibitors (fluvoxamine, gemfibrozil): ↑ Eltrombopag levels
Statins: May ↑ risk of myopathy

8. Monitoring Requirements

Parameter	Frequency	Action Threshold
Platelet count	Weekly until stable, then monthly	>150,000/μL → reduce dose
Liver enzymes	Every 2 weeks ×3 months, then monthly	ALT >3× ULN → interrupt
Bone marrow biopsy	Annually (if long-term use)	Reticulin fibrosis → reconsider therapy

9. Cost & Alternatives

Price: ~$5,000–$7,000/month (brand)
Alternatives:
- Romiplostim (Nplate) (subcutaneous TPO-RA)
- Avatrombopag (Doptelet) (alternative oral TPO-RA)

10. Conclusion

REVOLADE 50 mg is a potent oral thrombopoietin agonist for ITP, SAA, and HCV-related thrombocytopenia.

Key Takeaways:

✔ Effective in refractory ITP (60–80% response rate)
✔ Convenient oral dosing (vs. injectable alternatives)
✔ Requires strict monitoring (liver, platelets, bone marrow)

Clinical Pearls:

Start low, go slow (especially in elderly)
Discontinue if no response after 4 weeks
Consider thromboprophylaxis if platelets >400,000/μL

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

1. Definition & Mechanism

Generic Name: Eltrombopag
Brand Name: Revolade (also marketed as Promacta in some regions)
Class: Thrombopoietin receptor agonist (TPO-RA) (oral small-molecule)
Mechanism: Binds to the TPO receptor on megakaryocytes → stimulates platelet production
Half-life: ~21–32 hours (allows once-daily dosing)

2. Indications & Importance

✅ FDA/EMA-Approved Uses:

Chronic Immune Thrombocytopenia (ITP) (adults & children ≥1 year) – 2nd-line therapy
Severe Aplastic Anemia (SAA) (in combination with immunosuppressants)
Hepatitis C-associated Thrombocytopenia (to permit antiviral therapy)
Chemotherapy-Induced Thrombocytopenia (under investigation)

⚠️ Not for use in:

Myelodysplastic syndromes (MDS) (↑ risk of leukemic progression)
Patients with normal platelet counts

3. Dosage & Administration

Standard Dosing Guidelines

Indication	Starting Dose	Dose Adjustment	Max Dose
ITP (Adults)	50 mg once daily	Adjust by 25 mg every 2 weeks	75 mg/day
ITP (Children 1-5 yrs)	25 mg once daily	Adjust by 12.5–25 mg	75 mg/day
SAA	150 mg once daily	Reduce if platelets >200,000/μL	150 mg/day
HCV Thrombocytopenia	25 mg once daily	Titrate weekly	100 mg/day

Key Administration Points:

Take on an empty stomach (1 hr before or 2 hrs after food)
Avoid calcium-rich foods/drugs (dairy, antacids – separate by ≥4 hrs)
Do not crush tablets (film-coated)

4. Side Effects & Toxicity

Common (≥10%)

Headache (20%)
Nausea, diarrhea (15%)
Fatigue (12%)
Mild liver enzyme elevation (ALT/AST ↑)

Serious (Monitor Closely)

Hepatotoxicity (rare but severe)
Thrombosis (arterial/venous – especially if platelets >400,000/μL)
Bone Marrow Fibrosis (long-term use)
Cataracts (ophthalmic exams recommended)

5. Storage & Handling

Store at 20–25°C (room temperature)
Keep in original blister pack (protects from moisture)
Do not freeze

6. Contraindications & Warnings

❌ Absolute Contraindications:

Hypersensitivity to eltrombopag
Severe hepatic impairment (Child-Pugh C)
Active thrombosis

⚠️ Black Box Warnings (FDA):

Risk of hepatotoxicity (monitor LFTs every 2 weeks initially)
Risk of bone marrow fibrosis (check reticulin staining if long-term use)

7. Drug Interactions

Polyvalent cations (Ca²⁺, Mg²⁺, Fe²⁺): ↓ Absorption (separate doses by 4 hrs)
CYP1A2/CYP2C8 inhibitors (fluvoxamine, gemfibrozil): ↑ Eltrombopag levels
Statins: May ↑ risk of myopathy

8. Monitoring Requirements

Parameter	Frequency	Action Threshold
Platelet count	Weekly until stable, then monthly	>150,000/μL → reduce dose
Liver enzymes	Every 2 weeks ×3 months, then monthly	ALT >3× ULN → interrupt
Bone marrow biopsy	Annually (if long-term use)	Reticulin fibrosis → reconsider therapy

9. Cost & Alternatives

Price: ~$5,000–$7,000/month (brand)
Alternatives:
- Romiplostim (Nplate) (subcutaneous TPO-RA)
- Avatrombopag (Doptelet) (alternative oral TPO-RA)

10. Conclusion

REVOLADE 50 mg is a potent oral thrombopoietin agonist for ITP, SAA, and HCV-related thrombocytopenia.

Key Takeaways:

✔ Effective in refractory ITP (60–80% response rate)
✔ Convenient oral dosing (vs. injectable alternatives)
✔ Requires strict monitoring (liver, platelets, bone marrow)

Clinical Pearls:

Start low, go slow (especially in elderly)
Discontinue if no response after 4 weeks
Consider thromboprophylaxis if platelets >400,000/μL

Reviews

There are no reviews yet.

Be the first to review “REVOLADE 50MG”

Description
Reviews (0)

1. Definition & Mechanism

Generic Name: Eltrombopag
Brand Name: Revolade (also marketed as Promacta in some regions)
Class: Thrombopoietin receptor agonist (TPO-RA) (oral small-molecule)
Mechanism: Binds to the TPO receptor on megakaryocytes → stimulates platelet production
Half-life: ~21–32 hours (allows once-daily dosing)

2. Indications & Importance

✅ FDA/EMA-Approved Uses:

Chronic Immune Thrombocytopenia (ITP) (adults & children ≥1 year) – 2nd-line therapy
Severe Aplastic Anemia (SAA) (in combination with immunosuppressants)
Hepatitis C-associated Thrombocytopenia (to permit antiviral therapy)
Chemotherapy-Induced Thrombocytopenia (under investigation)

⚠️ Not for use in:

Myelodysplastic syndromes (MDS) (↑ risk of leukemic progression)
Patients with normal platelet counts

3. Dosage & Administration

Standard Dosing Guidelines

Indication	Starting Dose	Dose Adjustment	Max Dose
ITP (Adults)	50 mg once daily	Adjust by 25 mg every 2 weeks	75 mg/day
ITP (Children 1-5 yrs)	25 mg once daily	Adjust by 12.5–25 mg	75 mg/day
SAA	150 mg once daily	Reduce if platelets >200,000/μL	150 mg/day
HCV Thrombocytopenia	25 mg once daily	Titrate weekly	100 mg/day

Key Administration Points:

Take on an empty stomach (1 hr before or 2 hrs after food)
Avoid calcium-rich foods/drugs (dairy, antacids – separate by ≥4 hrs)
Do not crush tablets (film-coated)

4. Side Effects & Toxicity

Common (≥10%)

Headache (20%)
Nausea, diarrhea (15%)
Fatigue (12%)
Mild liver enzyme elevation (ALT/AST ↑)

Serious (Monitor Closely)

Hepatotoxicity (rare but severe)
Thrombosis (arterial/venous – especially if platelets >400,000/μL)
Bone Marrow Fibrosis (long-term use)
Cataracts (ophthalmic exams recommended)

5. Storage & Handling

Store at 20–25°C (room temperature)
Keep in original blister pack (protects from moisture)
Do not freeze

6. Contraindications & Warnings

❌ Absolute Contraindications:

Hypersensitivity to eltrombopag
Severe hepatic impairment (Child-Pugh C)
Active thrombosis

⚠️ Black Box Warnings (FDA):

Risk of hepatotoxicity (monitor LFTs every 2 weeks initially)
Risk of bone marrow fibrosis (check reticulin staining if long-term use)

7. Drug Interactions

Polyvalent cations (Ca²⁺, Mg²⁺, Fe²⁺): ↓ Absorption (separate doses by 4 hrs)
CYP1A2/CYP2C8 inhibitors (fluvoxamine, gemfibrozil): ↑ Eltrombopag levels
Statins: May ↑ risk of myopathy

8. Monitoring Requirements

Parameter	Frequency	Action Threshold
Platelet count	Weekly until stable, then monthly	>150,000/μL → reduce dose
Liver enzymes	Every 2 weeks ×3 months, then monthly	ALT >3× ULN → interrupt
Bone marrow biopsy	Annually (if long-term use)	Reticulin fibrosis → reconsider therapy

9. Cost & Alternatives

Price: ~$5,000–$7,000/month (brand)
Alternatives:
- Romiplostim (Nplate) (subcutaneous TPO-RA)
- Avatrombopag (Doptelet) (alternative oral TPO-RA)

10. Conclusion

REVOLADE 50 mg is a potent oral thrombopoietin agonist for ITP, SAA, and HCV-related thrombocytopenia.

Key Takeaways:

✔ Effective in refractory ITP (60–80% response rate)
✔ Convenient oral dosing (vs. injectable alternatives)
✔ Requires strict monitoring (liver, platelets, bone marrow)

Clinical Pearls:

Start low, go slow (especially in elderly)
Discontinue if no response after 4 weeks
Consider thromboprophylaxis if platelets >400,000/μL

Reviews

There are no reviews yet.

Be the first to review “REVOLADE 50MG”

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