ALLEGRA

Allergy

Description
Shipping Options
Customer Reviews

1. Introduction

Allegra is a brand name for fexofenadine, a third-generation antihistamine known for:

Non-sedating properties (minimal CNS penetration)
Rapid onset of action
24-hour duration with single daily dose
Cardiovascular safety (no QT prolongation)

2. Key Specifications

Generic Name: Fexofenadine hydrochloride
Brand Names: Allegra (global), Telfast (some markets)
Dosage Forms:
- Tablets (30mg, 60mg, 120mg, 180mg)
- Oral suspension (30mg/5mL)
- Disintegrating tablets (30mg)
Manufacturer: Sanofi (originator), multiple generics

3. Therapeutic Advantages

✔ No sedation (unlike 1st-gen antihistamines) ✔ No cardiac effects (safe in cardiac patients) ✔ No food interactions (newer formulation) ✔ Pediatric-friendly formulations

4. Mechanism of Action

Selective peripheral H1-receptor antagonist
Minimal crossing of blood-brain barrier
Additional anti-inflammatory effects:
- Reduces ICAM-1 expression
- Inhibits eosinophil migration

5. Approved Indications

Allergic rhinitis (seasonal/perennial)
Chronic idiopathic urticaria
Allergic conjunctivitis (off-label)
Atopic dermatitis (adjunct therapy)

6. Dosage & Administration

Standard Dosing:

Adults/Children ≥12 yrs: 180mg once daily or 60mg BID
Children 6-11 yrs: 30mg BID
Children 2-5 yrs: 15mg BID (oral suspension)
Renal impairment: Reduce dose by 50% (CrCl <80mL/min)

Administration Tips:

Take with water (avoid fruit juices)
Can be taken with/without food
Morning dosing preferred for 24-hour coverage

7. Safety Profile

Common ADRs (≤2%):

Headache (1.5%)
Dizziness (0.8%)
Nausea (0.6%)
Fatigue (0.3%)

Rare Effects:

Hypersensitivity reactions
Back pain
Dysmenorrhea

8. Pharmacokinetics

Onset: 1-2 hours
Peak: 2-3 hours
Duration: 24 hours
Protein binding: 60-70%
Half-life: 14-18 hours
Excretion: Biliary (80%) and renal (10%)

9. Comparative Advantages

Parameter	Fexofenadine	Cetirizine	Loratadine
Sedation	None	Moderate	Minimal
Cardiac safety	Excellent	Good	Good
Food effects	Avoid juice	None	None
Cost	Higher	Lower	Moderate

10. Important Precautions

⚠ Contraindications:

Hypersensitivity to fexofenadine
Severe renal impairment (CrCl <30mL/min)

⚠ Special Populations:

Pregnancy: Category C (use if benefits>risks)
Elderly: May need dose adjustment
Children: Safe ≥2 years (suspension available)

⚠ Drug Interactions:

Fruit juices (orange, apple, grapefruit) decrease absorption
Antacids (aluminum/magnesium) decrease absorption
Erythromycin/Ketoconazole increase levels

11. Storage Requirements

Store at 20-25°C
Protect from moisture
Suspension: Stable for 30 days after opening

12. Clinical Pearls

• First choice for pilots/drivers (non-sedating) • Preferred option for patients with cardiac concerns • Best taken in morning for 24-hour coverage • Avoid with fruit juices (take with water)

13. Conclusion

Allegra represents the gold standard in non-sedating antihistamines, offering excellent safety and efficacy for allergic conditions. Its unique pharmacokinetic profile and lack of CNS effects make it ideal for patients requiring alertness during treatment.

1. Introduction

Allegra is a brand name for fexofenadine, a third-generation antihistamine known for:

Non-sedating properties (minimal CNS penetration)
Rapid onset of action
24-hour duration with single daily dose
Cardiovascular safety (no QT prolongation)

2. Key Specifications

Generic Name: Fexofenadine hydrochloride
Brand Names: Allegra (global), Telfast (some markets)
Dosage Forms:
- Tablets (30mg, 60mg, 120mg, 180mg)
- Oral suspension (30mg/5mL)
- Disintegrating tablets (30mg)
Manufacturer: Sanofi (originator), multiple generics

3. Therapeutic Advantages

✔ No sedation (unlike 1st-gen antihistamines)
✔ No cardiac effects (safe in cardiac patients)
✔ No food interactions (newer formulation)
✔ Pediatric-friendly formulations

4. Mechanism of Action

Selective peripheral H1-receptor antagonist
Minimal crossing of blood-brain barrier
Additional anti-inflammatory effects:
- Reduces ICAM-1 expression
- Inhibits eosinophil migration

5. Approved Indications

Allergic rhinitis (seasonal/perennial)
Chronic idiopathic urticaria
Allergic conjunctivitis (off-label)
Atopic dermatitis (adjunct therapy)

6. Dosage & Administration

Standard Dosing:

Adults/Children ≥12 yrs: 180mg once daily or 60mg BID
Children 6-11 yrs: 30mg BID
Children 2-5 yrs: 15mg BID (oral suspension)
Renal impairment: Reduce dose by 50% (CrCl <80mL/min)

Administration Tips:

Take with water (avoid fruit juices)
Can be taken with/without food
Morning dosing preferred for 24-hour coverage

7. Safety Profile

Common ADRs (≤2%):

Headache (1.5%)
Dizziness (0.8%)
Nausea (0.6%)
Fatigue (0.3%)

Rare Effects:

Hypersensitivity reactions
Back pain
Dysmenorrhea

8. Pharmacokinetics

Onset: 1-2 hours
Peak: 2-3 hours
Duration: 24 hours
Protein binding: 60-70%
Half-life: 14-18 hours
Excretion: Biliary (80%) and renal (10%)

9. Comparative Advantages

Parameter	Fexofenadine	Cetirizine	Loratadine
Sedation	None	Moderate	Minimal
Cardiac safety	Excellent	Good	Good
Food effects	Avoid juice	None	None
Cost	Higher	Lower	Moderate

10. Important Precautions

⚠ Contraindications:

Hypersensitivity to fexofenadine
Severe renal impairment (CrCl <30mL/min)

⚠ Special Populations:

Pregnancy: Category C (use if benefits>risks)
Elderly: May need dose adjustment
Children: Safe ≥2 years (suspension available)

⚠ Drug Interactions:

Fruit juices (orange, apple, grapefruit) decrease absorption
Antacids (aluminum/magnesium) decrease absorption
Erythromycin/Ketoconazole increase levels

11. Storage Requirements

Store at 20-25°C
Protect from moisture
Suspension: Stable for 30 days after opening

12. Clinical Pearls

• First choice for pilots/drivers (non-sedating)
• Preferred option for patients with cardiac concerns
• Best taken in morning for 24-hour coverage
• Avoid with fruit juices (take with water)

13. Conclusion

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

1. Introduction

Allegra is a brand name for fexofenadine, a third-generation antihistamine known for:

Non-sedating properties (minimal CNS penetration)
Rapid onset of action
24-hour duration with single daily dose
Cardiovascular safety (no QT prolongation)

2. Key Specifications

Generic Name: Fexofenadine hydrochloride
Brand Names: Allegra (global), Telfast (some markets)
Dosage Forms:
- Tablets (30mg, 60mg, 120mg, 180mg)
- Oral suspension (30mg/5mL)
- Disintegrating tablets (30mg)
Manufacturer: Sanofi (originator), multiple generics

3. Therapeutic Advantages

✔ No sedation (unlike 1st-gen antihistamines)
✔ No cardiac effects (safe in cardiac patients)
✔ No food interactions (newer formulation)
✔ Pediatric-friendly formulations

4. Mechanism of Action

Selective peripheral H1-receptor antagonist
Minimal crossing of blood-brain barrier
Additional anti-inflammatory effects:
- Reduces ICAM-1 expression
- Inhibits eosinophil migration

5. Approved Indications

Allergic rhinitis (seasonal/perennial)
Chronic idiopathic urticaria
Allergic conjunctivitis (off-label)
Atopic dermatitis (adjunct therapy)

6. Dosage & Administration

Standard Dosing:

Adults/Children ≥12 yrs: 180mg once daily or 60mg BID
Children 6-11 yrs: 30mg BID
Children 2-5 yrs: 15mg BID (oral suspension)
Renal impairment: Reduce dose by 50% (CrCl <80mL/min)

Administration Tips:

Take with water (avoid fruit juices)
Can be taken with/without food
Morning dosing preferred for 24-hour coverage

7. Safety Profile

Common ADRs (≤2%):

Headache (1.5%)
Dizziness (0.8%)
Nausea (0.6%)
Fatigue (0.3%)

Rare Effects:

Hypersensitivity reactions
Back pain
Dysmenorrhea

8. Pharmacokinetics

Onset: 1-2 hours
Peak: 2-3 hours
Duration: 24 hours
Protein binding: 60-70%
Half-life: 14-18 hours
Excretion: Biliary (80%) and renal (10%)

9. Comparative Advantages

Parameter	Fexofenadine	Cetirizine	Loratadine
Sedation	None	Moderate	Minimal
Cardiac safety	Excellent	Good	Good
Food effects	Avoid juice	None	None
Cost	Higher	Lower	Moderate

10. Important Precautions

⚠ Contraindications:

Hypersensitivity to fexofenadine
Severe renal impairment (CrCl <30mL/min)

⚠ Special Populations:

Pregnancy: Category C (use if benefits>risks)
Elderly: May need dose adjustment
Children: Safe ≥2 years (suspension available)

⚠ Drug Interactions:

Fruit juices (orange, apple, grapefruit) decrease absorption
Antacids (aluminum/magnesium) decrease absorption
Erythromycin/Ketoconazole increase levels

11. Storage Requirements

Store at 20-25°C
Protect from moisture
Suspension: Stable for 30 days after opening

12. Clinical Pearls

• First choice for pilots/drivers (non-sedating)
• Preferred option for patients with cardiac concerns
• Best taken in morning for 24-hour coverage
• Avoid with fruit juices (take with water)

13. Conclusion

Reviews

There are no reviews yet.

Be the first to review “ALLEGRA”

Description
Reviews (0)

1. Introduction

Allegra is a brand name for fexofenadine, a third-generation antihistamine known for:

Non-sedating properties (minimal CNS penetration)
Rapid onset of action
24-hour duration with single daily dose
Cardiovascular safety (no QT prolongation)

2. Key Specifications

Generic Name: Fexofenadine hydrochloride
Brand Names: Allegra (global), Telfast (some markets)
Dosage Forms:
- Tablets (30mg, 60mg, 120mg, 180mg)
- Oral suspension (30mg/5mL)
- Disintegrating tablets (30mg)
Manufacturer: Sanofi (originator), multiple generics

3. Therapeutic Advantages

✔ No sedation (unlike 1st-gen antihistamines)
✔ No cardiac effects (safe in cardiac patients)
✔ No food interactions (newer formulation)
✔ Pediatric-friendly formulations

4. Mechanism of Action

Selective peripheral H1-receptor antagonist
Minimal crossing of blood-brain barrier
Additional anti-inflammatory effects:
- Reduces ICAM-1 expression
- Inhibits eosinophil migration

5. Approved Indications

Allergic rhinitis (seasonal/perennial)
Chronic idiopathic urticaria
Allergic conjunctivitis (off-label)
Atopic dermatitis (adjunct therapy)

6. Dosage & Administration

Standard Dosing:

Adults/Children ≥12 yrs: 180mg once daily or 60mg BID
Children 6-11 yrs: 30mg BID
Children 2-5 yrs: 15mg BID (oral suspension)
Renal impairment: Reduce dose by 50% (CrCl <80mL/min)

Administration Tips:

Take with water (avoid fruit juices)
Can be taken with/without food
Morning dosing preferred for 24-hour coverage

7. Safety Profile

Common ADRs (≤2%):

Headache (1.5%)
Dizziness (0.8%)
Nausea (0.6%)
Fatigue (0.3%)

Rare Effects:

Hypersensitivity reactions
Back pain
Dysmenorrhea

8. Pharmacokinetics

Onset: 1-2 hours
Peak: 2-3 hours
Duration: 24 hours
Protein binding: 60-70%
Half-life: 14-18 hours
Excretion: Biliary (80%) and renal (10%)

9. Comparative Advantages

Parameter	Fexofenadine	Cetirizine	Loratadine
Sedation	None	Moderate	Minimal
Cardiac safety	Excellent	Good	Good
Food effects	Avoid juice	None	None
Cost	Higher	Lower	Moderate

10. Important Precautions

⚠ Contraindications:

Hypersensitivity to fexofenadine
Severe renal impairment (CrCl <30mL/min)

⚠ Special Populations:

Pregnancy: Category C (use if benefits>risks)
Elderly: May need dose adjustment
Children: Safe ≥2 years (suspension available)

⚠ Drug Interactions:

Fruit juices (orange, apple, grapefruit) decrease absorption
Antacids (aluminum/magnesium) decrease absorption
Erythromycin/Ketoconazole increase levels

11. Storage Requirements

Store at 20-25°C
Protect from moisture
Suspension: Stable for 30 days after opening

12. Clinical Pearls

• First choice for pilots/drivers (non-sedating)
• Preferred option for patients with cardiac concerns
• Best taken in morning for 24-hour coverage
• Avoid with fruit juices (take with water)

13. Conclusion

Reviews

There are no reviews yet.

Be the first to review “ALLEGRA”

Medical Disclaimer

Anteka Pharmacy primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on Anteka Pharmacy. Our mission is to support, not replace, the doctor-patient relationship.