CETCIP

Allergy

Description
Shipping Options
Customer Reviews

1. Introduction

Cetcip is a brand name for cetirizine, a second-generation antihistamine widely used for allergic conditions. Unlike older antihistamines, it causes minimal sedation while effectively controlling allergy symptoms.

2. Key Specifications

Generic Name: Cetirizine hydrochloride
Brand Names: Cetcip (India), Zyrtec (international)
Dosage Forms:
- Tablets (10 mg)
- Syrup (5 mg/5 mL)
- Chewable tablets (5 mg, 10 mg)
Manufacturer: Cipla (Cetcip brand)

3. Therapeutic Advantages

✔ Rapid onset (within 1 hour) ✔ 24-hour duration with single daily dose ✔ Minimal sedation at recommended doses ✔ Additional anti-inflammatory properties

4. Mechanism of Action

Selective peripheral H1-receptor antagonist
Inhibits:
- Histamine-induced wheal and flare
- Eosinophil migration
- ICAM-1 expression
Minimal anticholinergic effects

5. Approved Indications

Allergic rhinitis (seasonal/perennial)
Chronic urticaria
Atopic dermatitis (adjunct therapy)
Allergic conjunctivitis (off-label)

6. Dosage & Administration

Standard Dosing:

Adults/Children ≥12 yrs: 10 mg once daily
Children 6-11 yrs: 5-10 mg once daily
Children 2-5 yrs: 2.5-5 mg once daily
Renal impairment: 5 mg daily (CrCl 11-31 mL/min)

Special Notes:

May take with/without food
Evening dosing may help with nighttime symptoms
Not recommended for children <2 years

7. Safety Profile

Common ADRs (≤5%):

Somnolence (11-14%)
Dry mouth (2-5%)
Fatigue (1-4%)
Headache (5-7%)

Rare Serious Effects:

QT prolongation (with overdose)
Severe hypersensitivity
Seizures (in predisposed patients)

8. Pharmacokinetic Highlights

Bioavailability: ~70%
Protein binding: 93%
Half-life: 8-9 hours (permits once-daily dosing)
Metabolism: Minimal hepatic metabolism
Excretion: Renal (70% unchanged)

9. Comparative Advantages

Parameter	Cetirizine	Loratadine
Onset	Faster	Slower
Sedation	Moderate	Minimal
Cost	Lower	Moderate
Renal excretion	Higher	Lower

10. Important Precautions

⚠ Contraindications:

Hypersensitivity to hydroxyzine/cetirizine
End-stage renal disease

⚠ Special Populations:

Pregnancy: Category B (generally safe)
Lactation: Small amounts excreted in milk

⚠ Drug Interactions:

CNS depressants: Additive sedation
Theophylline: May decrease cetirizine clearance

11. Storage Requirements

Store at 15-30°C
Protect from moisture
Syrup: Stable for 6 months after opening

12. Clinical Pearls

• Preferred choice for:

Patients with hepatic impairment
Those needing rapid relief • Best taken in evening if sedation occurs • Cost-effective alternative to newer antihistamines

13. Conclusion

Cetcip offers effective allergy control with minimal side effects, making it a first-line choice for allergic conditions. Its predictable pharmacokinetics and safety profile support widespread use in both adults and children.

1. Introduction

2. Key Specifications

Generic Name: Cetirizine hydrochloride
Brand Names: Cetcip (India), Zyrtec (international)
Dosage Forms:
- Tablets (10 mg)
- Syrup (5 mg/5 mL)
- Chewable tablets (5 mg, 10 mg)
Manufacturer: Cipla (Cetcip brand)

3. Therapeutic Advantages

✔ Rapid onset (within 1 hour)
✔ 24-hour duration with single daily dose
✔ Minimal sedation at recommended doses
✔ Additional anti-inflammatory properties

4. Mechanism of Action

Selective peripheral H1-receptor antagonist
Inhibits:
- Histamine-induced wheal and flare
- Eosinophil migration
- ICAM-1 expression
Minimal anticholinergic effects

5. Approved Indications

Allergic rhinitis (seasonal/perennial)
Chronic urticaria
Atopic dermatitis (adjunct therapy)
Allergic conjunctivitis (off-label)

6. Dosage & Administration

Standard Dosing:

Adults/Children ≥12 yrs: 10 mg once daily
Children 6-11 yrs: 5-10 mg once daily
Children 2-5 yrs: 2.5-5 mg once daily
Renal impairment: 5 mg daily (CrCl 11-31 mL/min)

Special Notes:

May take with/without food
Evening dosing may help with nighttime symptoms
Not recommended for children <2 years

7. Safety Profile

Common ADRs (≤5%):

Somnolence (11-14%)
Dry mouth (2-5%)
Fatigue (1-4%)
Headache (5-7%)

Rare Serious Effects:

QT prolongation (with overdose)
Severe hypersensitivity
Seizures (in predisposed patients)

8. Pharmacokinetic Highlights

Bioavailability: ~70%
Protein binding: 93%
Half-life: 8-9 hours (permits once-daily dosing)
Metabolism: Minimal hepatic metabolism
Excretion: Renal (70% unchanged)

9. Comparative Advantages

Parameter	Cetirizine	Loratadine
Onset	Faster	Slower
Sedation	Moderate	Minimal
Cost	Lower	Moderate
Renal excretion	Higher	Lower

10. Important Precautions

⚠ Contraindications:

Hypersensitivity to hydroxyzine/cetirizine
End-stage renal disease

⚠ Special Populations:

Pregnancy: Category B (generally safe)
Lactation: Small amounts excreted in milk

⚠ Drug Interactions:

CNS depressants: Additive sedation
Theophylline: May decrease cetirizine clearance

11. Storage Requirements

Store at 15-30°C
Protect from moisture
Syrup: Stable for 6 months after opening

12. Clinical Pearls

• Preferred choice for:

Patients with hepatic impairment
Those needing rapid relief
• Best taken in evening if sedation occurs
• Cost-effective alternative to newer antihistamines

13. Conclusion

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

1. Introduction

2. Key Specifications

Generic Name: Cetirizine hydrochloride
Brand Names: Cetcip (India), Zyrtec (international)
Dosage Forms:
- Tablets (10 mg)
- Syrup (5 mg/5 mL)
- Chewable tablets (5 mg, 10 mg)
Manufacturer: Cipla (Cetcip brand)

3. Therapeutic Advantages

✔ Rapid onset (within 1 hour)
✔ 24-hour duration with single daily dose
✔ Minimal sedation at recommended doses
✔ Additional anti-inflammatory properties

4. Mechanism of Action

Selective peripheral H1-receptor antagonist
Inhibits:
- Histamine-induced wheal and flare
- Eosinophil migration
- ICAM-1 expression
Minimal anticholinergic effects

5. Approved Indications

Allergic rhinitis (seasonal/perennial)
Chronic urticaria
Atopic dermatitis (adjunct therapy)
Allergic conjunctivitis (off-label)

6. Dosage & Administration

Standard Dosing:

Adults/Children ≥12 yrs: 10 mg once daily
Children 6-11 yrs: 5-10 mg once daily
Children 2-5 yrs: 2.5-5 mg once daily
Renal impairment: 5 mg daily (CrCl 11-31 mL/min)

Special Notes:

May take with/without food
Evening dosing may help with nighttime symptoms
Not recommended for children <2 years

7. Safety Profile

Common ADRs (≤5%):

Somnolence (11-14%)
Dry mouth (2-5%)
Fatigue (1-4%)
Headache (5-7%)

Rare Serious Effects:

QT prolongation (with overdose)
Severe hypersensitivity
Seizures (in predisposed patients)

8. Pharmacokinetic Highlights

Bioavailability: ~70%
Protein binding: 93%
Half-life: 8-9 hours (permits once-daily dosing)
Metabolism: Minimal hepatic metabolism
Excretion: Renal (70% unchanged)

9. Comparative Advantages

Parameter	Cetirizine	Loratadine
Onset	Faster	Slower
Sedation	Moderate	Minimal
Cost	Lower	Moderate
Renal excretion	Higher	Lower

10. Important Precautions

⚠ Contraindications:

Hypersensitivity to hydroxyzine/cetirizine
End-stage renal disease

⚠ Special Populations:

Pregnancy: Category B (generally safe)
Lactation: Small amounts excreted in milk

⚠ Drug Interactions:

CNS depressants: Additive sedation
Theophylline: May decrease cetirizine clearance

11. Storage Requirements

Store at 15-30°C
Protect from moisture
Syrup: Stable for 6 months after opening

12. Clinical Pearls

• Preferred choice for:

Patients with hepatic impairment
Those needing rapid relief
• Best taken in evening if sedation occurs
• Cost-effective alternative to newer antihistamines

13. Conclusion

Reviews

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Be the first to review “CETCIP”

Description
Reviews (0)

1. Introduction

2. Key Specifications

Generic Name: Cetirizine hydrochloride
Brand Names: Cetcip (India), Zyrtec (international)
Dosage Forms:
- Tablets (10 mg)
- Syrup (5 mg/5 mL)
- Chewable tablets (5 mg, 10 mg)
Manufacturer: Cipla (Cetcip brand)

3. Therapeutic Advantages

✔ Rapid onset (within 1 hour)
✔ 24-hour duration with single daily dose
✔ Minimal sedation at recommended doses
✔ Additional anti-inflammatory properties

4. Mechanism of Action

Selective peripheral H1-receptor antagonist
Inhibits:
- Histamine-induced wheal and flare
- Eosinophil migration
- ICAM-1 expression
Minimal anticholinergic effects

5. Approved Indications

Allergic rhinitis (seasonal/perennial)
Chronic urticaria
Atopic dermatitis (adjunct therapy)
Allergic conjunctivitis (off-label)

6. Dosage & Administration

Standard Dosing:

Adults/Children ≥12 yrs: 10 mg once daily
Children 6-11 yrs: 5-10 mg once daily
Children 2-5 yrs: 2.5-5 mg once daily
Renal impairment: 5 mg daily (CrCl 11-31 mL/min)

Special Notes:

May take with/without food
Evening dosing may help with nighttime symptoms
Not recommended for children <2 years

7. Safety Profile

Common ADRs (≤5%):

Somnolence (11-14%)
Dry mouth (2-5%)
Fatigue (1-4%)
Headache (5-7%)

Rare Serious Effects:

QT prolongation (with overdose)
Severe hypersensitivity
Seizures (in predisposed patients)

8. Pharmacokinetic Highlights

Bioavailability: ~70%
Protein binding: 93%
Half-life: 8-9 hours (permits once-daily dosing)
Metabolism: Minimal hepatic metabolism
Excretion: Renal (70% unchanged)

9. Comparative Advantages

Parameter	Cetirizine	Loratadine
Onset	Faster	Slower
Sedation	Moderate	Minimal
Cost	Lower	Moderate
Renal excretion	Higher	Lower

10. Important Precautions

⚠ Contraindications:

Hypersensitivity to hydroxyzine/cetirizine
End-stage renal disease

⚠ Special Populations:

Pregnancy: Category B (generally safe)
Lactation: Small amounts excreted in milk

⚠ Drug Interactions:

CNS depressants: Additive sedation
Theophylline: May decrease cetirizine clearance

11. Storage Requirements

Store at 15-30°C
Protect from moisture
Syrup: Stable for 6 months after opening

12. Clinical Pearls

• Preferred choice for:

Patients with hepatic impairment
Those needing rapid relief
• Best taken in evening if sedation occurs
• Cost-effective alternative to newer antihistamines

13. Conclusion

Reviews

There are no reviews yet.

Be the first to review “CETCIP”

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