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D-LORATIN

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1. Introduction

D-Loratin is a brand name for desloratadine, a potent third-generation antihistamine and primary active metabolite of loratadine. It offers enhanced efficacy with minimal sedation, making it ideal for long-term allergy management.

2. Key Specifications

  • Generic Name: Desloratadine

  • Brand Names: D-Loratin (India), Aerius/Clarinex (international)

  • Dosage Forms:

    • Tablets (5 mg)

    • Oral solution (2.5 mg/5 mL)

    • Dispersible tablets

  • Manufacturer: Cipla (D-Loratin brand)

3. Therapeutic Advantages

✔ 2-4× more potent than loratadine ✔ Non-sedating at recommended doses ✔ 24-hour duration with single daily dosing ✔ Additional anti-inflammatory properties

4. Mechanism of Action

  • Selective peripheral H1-receptor inverse agonist

  • Inhibits:

    • Histamine release from mast cells

    • Cytokine production (IL-4, IL-6, IL-13)

    • ICAM-1 expression

  • Minimal CNS penetration (brain/blood ratio <0.03)

5. Approved Indications

  • Allergic rhinitis (seasonal/perennial)

  • Chronic idiopathic urticaria

  • Allergic conjunctivitis (off-label)

  • Atopic dermatitis (adjunct therapy)

6. Dosage & Administration

Standard Dosing:

  • Adults/Adolescents (≥12 yrs): 5 mg once daily

  • Children (6-11 yrs): 2.5 mg once daily

  • Children (1-5 yrs): 1.25 mg once daily

  • Renal/hepatic impairment: No adjustment typically needed

Special Notes:

  • May take with/without food

  • Onset within 1-3 hours

  • Peak effect at 3-6 hours

7. Safety Profile

Common ADRs (≤5%):

  • Headache (7%)

  • Dry mouth (3%)

  • Fatigue (2%)

  • Pharyngitis (2%)

Rare Serious Effects:

  • QT prolongation (with overdose)

  • Hypersensitivity reactions

  • Elevated liver enzymes

8. Pharmacokinetic Highlights

  • Bioavailability: ~85%

  • Protein binding: 83-87%

  • Half-life: 27 hours (permits once-daily dosing)

  • Metabolism: Hepatic (CYP3A4/2C8)

  • Excretion: Urine (40%) and feces (56%)

9. Comparative Advantages

Parameter Desloratadine Loratadine
Potency 2-4× higher Baseline
Onset Faster Slower
Drug interactions Fewer Moderate
Cost Higher Lower

10. Important Precautions

⚠ Contraindications:

  • Hypersensitivity to loratadine/desloratadine

  • Severe hepatic impairment

⚠ Special Populations:

  • Pregnancy: Category C (use cautiously)

  • Lactation: Excreted in milk (consider alternatives)

⚠ Drug Interactions:

  • Erythromycin/ketoconazole: Increase desloratadine levels

  • CNS depressants: Minimal interaction

11. Storage Requirements

  • Store at 15-30°C

  • Protect from light/moisture

  • Oral solution: Stable for 28 days after opening

12. Clinical Pearls

• Superior to loratadine for:

  • Nasal congestion relief

  • Chronic urticaria management • Preferred choice for:

  • Patients with hepatic impairment

  • Those requiring minimal sedation • Cost-benefit: Consider for patients unresponsive to loratadine

13. Conclusion

D-Loratin represents an advanced antihistamine option combining enhanced potency with excellent tolerability. Its once-daily dosing, rapid onset, and additional anti-allergic properties make it particularly valuable for patients requiring long-term allergy control.

1. Introduction

D-Loratin is a brand name for desloratadine, a potent third-generation antihistamine and primary active metabolite of loratadine. It offers enhanced efficacy with minimal sedation, making it ideal for long-term allergy management.

2. Key Specifications

  • Generic Name: Desloratadine

  • Brand Names: D-Loratin (India), Aerius/Clarinex (international)

  • Dosage Forms:

    • Tablets (5 mg)

    • Oral solution (2.5 mg/5 mL)

    • Dispersible tablets

  • Manufacturer: Cipla (D-Loratin brand)

3. Therapeutic Advantages

✔ 2-4× more potent than loratadine
✔ Non-sedating at recommended doses
✔ 24-hour duration with single daily dosing
✔ Additional anti-inflammatory properties

4. Mechanism of Action

  • Selective peripheral H1-receptor inverse agonist

  • Inhibits:

    • Histamine release from mast cells

    • Cytokine production (IL-4, IL-6, IL-13)

    • ICAM-1 expression

  • Minimal CNS penetration (brain/blood ratio <0.03)

5. Approved Indications

  • Allergic rhinitis (seasonal/perennial)

  • Chronic idiopathic urticaria

  • Allergic conjunctivitis (off-label)

  • Atopic dermatitis (adjunct therapy)

6. Dosage & Administration

Standard Dosing:

  • Adults/Adolescents (≥12 yrs): 5 mg once daily

  • Children (6-11 yrs): 2.5 mg once daily

  • Children (1-5 yrs): 1.25 mg once daily

  • Renal/hepatic impairment: No adjustment typically needed

Special Notes:

  • May take with/without food

  • Onset within 1-3 hours

  • Peak effect at 3-6 hours

7. Safety Profile

Common ADRs (≤5%):

  • Headache (7%)

  • Dry mouth (3%)

  • Fatigue (2%)

  • Pharyngitis (2%)

Rare Serious Effects:

  • QT prolongation (with overdose)

  • Hypersensitivity reactions

  • Elevated liver enzymes

8. Pharmacokinetic Highlights

  • Bioavailability: ~85%

  • Protein binding: 83-87%

  • Half-life: 27 hours (permits once-daily dosing)

  • Metabolism: Hepatic (CYP3A4/2C8)

  • Excretion: Urine (40%) and feces (56%)

9. Comparative Advantages

Parameter Desloratadine Loratadine
Potency 2-4× higher Baseline
Onset Faster Slower
Drug interactions Fewer Moderate
Cost Higher Lower

10. Important Precautions

⚠ Contraindications:

  • Hypersensitivity to loratadine/desloratadine

  • Severe hepatic impairment

⚠ Special Populations:

  • Pregnancy: Category C (use cautiously)

  • Lactation: Excreted in milk (consider alternatives)

⚠ Drug Interactions:

  • Erythromycin/ketoconazole: Increase desloratadine levels

  • CNS depressants: Minimal interaction

11. Storage Requirements

  • Store at 15-30°C

  • Protect from light/moisture

  • Oral solution: Stable for 28 days after opening

12. Clinical Pearls

• Superior to loratadine for:

  • Nasal congestion relief

  • Chronic urticaria management
    • Preferred choice for:

  • Patients with hepatic impairment

  • Those requiring minimal sedation
    • Cost-benefit: Consider for patients unresponsive to loratadine

13. Conclusion

D-Loratin represents an advanced antihistamine option combining enhanced potency with excellent tolerability. Its once-daily dosing, rapid onset, and additional anti-allergic properties make it particularly valuable for patients requiring long-term allergy control.

Shipping Options – 

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions – 

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

1. Introduction

D-Loratin is a brand name for desloratadine, a potent third-generation antihistamine and primary active metabolite of loratadine. It offers enhanced efficacy with minimal sedation, making it ideal for long-term allergy management.

2. Key Specifications

  • Generic Name: Desloratadine

  • Brand Names: D-Loratin (India), Aerius/Clarinex (international)

  • Dosage Forms:

    • Tablets (5 mg)

    • Oral solution (2.5 mg/5 mL)

    • Dispersible tablets

  • Manufacturer: Cipla (D-Loratin brand)

3. Therapeutic Advantages

✔ 2-4× more potent than loratadine
✔ Non-sedating at recommended doses
✔ 24-hour duration with single daily dosing
✔ Additional anti-inflammatory properties

4. Mechanism of Action

  • Selective peripheral H1-receptor inverse agonist

  • Inhibits:

    • Histamine release from mast cells

    • Cytokine production (IL-4, IL-6, IL-13)

    • ICAM-1 expression

  • Minimal CNS penetration (brain/blood ratio <0.03)

5. Approved Indications

  • Allergic rhinitis (seasonal/perennial)

  • Chronic idiopathic urticaria

  • Allergic conjunctivitis (off-label)

  • Atopic dermatitis (adjunct therapy)

6. Dosage & Administration

Standard Dosing:

  • Adults/Adolescents (≥12 yrs): 5 mg once daily

  • Children (6-11 yrs): 2.5 mg once daily

  • Children (1-5 yrs): 1.25 mg once daily

  • Renal/hepatic impairment: No adjustment typically needed

Special Notes:

  • May take with/without food

  • Onset within 1-3 hours

  • Peak effect at 3-6 hours

7. Safety Profile

Common ADRs (≤5%):

  • Headache (7%)

  • Dry mouth (3%)

  • Fatigue (2%)

  • Pharyngitis (2%)

Rare Serious Effects:

  • QT prolongation (with overdose)

  • Hypersensitivity reactions

  • Elevated liver enzymes

8. Pharmacokinetic Highlights

  • Bioavailability: ~85%

  • Protein binding: 83-87%

  • Half-life: 27 hours (permits once-daily dosing)

  • Metabolism: Hepatic (CYP3A4/2C8)

  • Excretion: Urine (40%) and feces (56%)

9. Comparative Advantages

Parameter Desloratadine Loratadine
Potency 2-4× higher Baseline
Onset Faster Slower
Drug interactions Fewer Moderate
Cost Higher Lower

10. Important Precautions

⚠ Contraindications:

  • Hypersensitivity to loratadine/desloratadine

  • Severe hepatic impairment

⚠ Special Populations:

  • Pregnancy: Category C (use cautiously)

  • Lactation: Excreted in milk (consider alternatives)

⚠ Drug Interactions:

  • Erythromycin/ketoconazole: Increase desloratadine levels

  • CNS depressants: Minimal interaction

11. Storage Requirements

  • Store at 15-30°C

  • Protect from light/moisture

  • Oral solution: Stable for 28 days after opening

12. Clinical Pearls

• Superior to loratadine for:

  • Nasal congestion relief

  • Chronic urticaria management
    • Preferred choice for:

  • Patients with hepatic impairment

  • Those requiring minimal sedation
    • Cost-benefit: Consider for patients unresponsive to loratadine

13. Conclusion

D-Loratin represents an advanced antihistamine option combining enhanced potency with excellent tolerability. Its once-daily dosing, rapid onset, and additional anti-allergic properties make it particularly valuable for patients requiring long-term allergy control.

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1. Introduction

D-Loratin is a brand name for desloratadine, a potent third-generation antihistamine and primary active metabolite of loratadine. It offers enhanced efficacy with minimal sedation, making it ideal for long-term allergy management.

2. Key Specifications

  • Generic Name: Desloratadine

  • Brand Names: D-Loratin (India), Aerius/Clarinex (international)

  • Dosage Forms:

    • Tablets (5 mg)

    • Oral solution (2.5 mg/5 mL)

    • Dispersible tablets

  • Manufacturer: Cipla (D-Loratin brand)

3. Therapeutic Advantages

✔ 2-4× more potent than loratadine
✔ Non-sedating at recommended doses
✔ 24-hour duration with single daily dosing
✔ Additional anti-inflammatory properties

4. Mechanism of Action

  • Selective peripheral H1-receptor inverse agonist

  • Inhibits:

    • Histamine release from mast cells

    • Cytokine production (IL-4, IL-6, IL-13)

    • ICAM-1 expression

  • Minimal CNS penetration (brain/blood ratio <0.03)

5. Approved Indications

  • Allergic rhinitis (seasonal/perennial)

  • Chronic idiopathic urticaria

  • Allergic conjunctivitis (off-label)

  • Atopic dermatitis (adjunct therapy)

6. Dosage & Administration

Standard Dosing:

  • Adults/Adolescents (≥12 yrs): 5 mg once daily

  • Children (6-11 yrs): 2.5 mg once daily

  • Children (1-5 yrs): 1.25 mg once daily

  • Renal/hepatic impairment: No adjustment typically needed

Special Notes:

  • May take with/without food

  • Onset within 1-3 hours

  • Peak effect at 3-6 hours

7. Safety Profile

Common ADRs (≤5%):

  • Headache (7%)

  • Dry mouth (3%)

  • Fatigue (2%)

  • Pharyngitis (2%)

Rare Serious Effects:

  • QT prolongation (with overdose)

  • Hypersensitivity reactions

  • Elevated liver enzymes

8. Pharmacokinetic Highlights

  • Bioavailability: ~85%

  • Protein binding: 83-87%

  • Half-life: 27 hours (permits once-daily dosing)

  • Metabolism: Hepatic (CYP3A4/2C8)

  • Excretion: Urine (40%) and feces (56%)

9. Comparative Advantages

Parameter Desloratadine Loratadine
Potency 2-4× higher Baseline
Onset Faster Slower
Drug interactions Fewer Moderate
Cost Higher Lower

10. Important Precautions

⚠ Contraindications:

  • Hypersensitivity to loratadine/desloratadine

  • Severe hepatic impairment

⚠ Special Populations:

  • Pregnancy: Category C (use cautiously)

  • Lactation: Excreted in milk (consider alternatives)

⚠ Drug Interactions:

  • Erythromycin/ketoconazole: Increase desloratadine levels

  • CNS depressants: Minimal interaction

11. Storage Requirements

  • Store at 15-30°C

  • Protect from light/moisture

  • Oral solution: Stable for 28 days after opening

12. Clinical Pearls

• Superior to loratadine for:

  • Nasal congestion relief

  • Chronic urticaria management
    • Preferred choice for:

  • Patients with hepatic impairment

  • Those requiring minimal sedation
    • Cost-benefit: Consider for patients unresponsive to loratadine

13. Conclusion

D-Loratin represents an advanced antihistamine option combining enhanced potency with excellent tolerability. Its once-daily dosing, rapid onset, and additional anti-allergic properties make it particularly valuable for patients requiring long-term allergy control.

Reviews

There are no reviews yet.

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