D-LORATIN

Allergy

Description
Shipping Options
Customer Reviews

1. Introduction

D-Loratin is a brand name for desloratadine, a potent third-generation antihistamine and primary active metabolite of loratadine. It offers enhanced efficacy with minimal sedation, making it ideal for long-term allergy management.

2. Key Specifications

Generic Name: Desloratadine
Brand Names: D-Loratin (India), Aerius/Clarinex (international)
Dosage Forms:
- Tablets (5 mg)
- Oral solution (2.5 mg/5 mL)
- Dispersible tablets
Manufacturer: Cipla (D-Loratin brand)

3. Therapeutic Advantages

✔ 2-4× more potent than loratadine ✔ Non-sedating at recommended doses ✔ 24-hour duration with single daily dosing ✔ Additional anti-inflammatory properties

4. Mechanism of Action

Selective peripheral H1-receptor inverse agonist
Inhibits:
- Histamine release from mast cells
- Cytokine production (IL-4, IL-6, IL-13)
- ICAM-1 expression
Minimal CNS penetration (brain/blood ratio <0.03)

5. Approved Indications

Allergic rhinitis (seasonal/perennial)
Chronic idiopathic urticaria
Allergic conjunctivitis (off-label)
Atopic dermatitis (adjunct therapy)

6. Dosage & Administration

Standard Dosing:

Adults/Adolescents (≥12 yrs): 5 mg once daily
Children (6-11 yrs): 2.5 mg once daily
Children (1-5 yrs): 1.25 mg once daily
Renal/hepatic impairment: No adjustment typically needed

Special Notes:

May take with/without food
Onset within 1-3 hours
Peak effect at 3-6 hours

7. Safety Profile

Common ADRs (≤5%):

Headache (7%)
Dry mouth (3%)
Fatigue (2%)
Pharyngitis (2%)

Rare Serious Effects:

QT prolongation (with overdose)
Hypersensitivity reactions
Elevated liver enzymes

8. Pharmacokinetic Highlights

Bioavailability: ~85%
Protein binding: 83-87%
Half-life: 27 hours (permits once-daily dosing)
Metabolism: Hepatic (CYP3A4/2C8)
Excretion: Urine (40%) and feces (56%)

9. Comparative Advantages

Parameter	Desloratadine	Loratadine
Potency	2-4× higher	Baseline
Onset	Faster	Slower
Drug interactions	Fewer	Moderate
Cost	Higher	Lower

10. Important Precautions

⚠ Contraindications:

Hypersensitivity to loratadine/desloratadine
Severe hepatic impairment

⚠ Special Populations:

Pregnancy: Category C (use cautiously)
Lactation: Excreted in milk (consider alternatives)

⚠ Drug Interactions:

Erythromycin/ketoconazole: Increase desloratadine levels
CNS depressants: Minimal interaction

11. Storage Requirements

Store at 15-30°C
Protect from light/moisture
Oral solution: Stable for 28 days after opening

12. Clinical Pearls

• Superior to loratadine for:

Nasal congestion relief
Chronic urticaria management • Preferred choice for:
Patients with hepatic impairment
Those requiring minimal sedation • Cost-benefit: Consider for patients unresponsive to loratadine

13. Conclusion

D-Loratin represents an advanced antihistamine option combining enhanced potency with excellent tolerability. Its once-daily dosing, rapid onset, and additional anti-allergic properties make it particularly valuable for patients requiring long-term allergy control.

1. Introduction

2. Key Specifications

Generic Name: Desloratadine
Brand Names: D-Loratin (India), Aerius/Clarinex (international)
Dosage Forms:
- Tablets (5 mg)
- Oral solution (2.5 mg/5 mL)
- Dispersible tablets
Manufacturer: Cipla (D-Loratin brand)

3. Therapeutic Advantages

✔ 2-4× more potent than loratadine
✔ Non-sedating at recommended doses
✔ 24-hour duration with single daily dosing
✔ Additional anti-inflammatory properties

4. Mechanism of Action

Selective peripheral H1-receptor inverse agonist
Inhibits:
- Histamine release from mast cells
- Cytokine production (IL-4, IL-6, IL-13)
- ICAM-1 expression
Minimal CNS penetration (brain/blood ratio <0.03)

5. Approved Indications

Allergic rhinitis (seasonal/perennial)
Chronic idiopathic urticaria
Allergic conjunctivitis (off-label)
Atopic dermatitis (adjunct therapy)

6. Dosage & Administration

Standard Dosing:

Adults/Adolescents (≥12 yrs): 5 mg once daily
Children (6-11 yrs): 2.5 mg once daily
Children (1-5 yrs): 1.25 mg once daily
Renal/hepatic impairment: No adjustment typically needed

Special Notes:

May take with/without food
Onset within 1-3 hours
Peak effect at 3-6 hours

7. Safety Profile

Common ADRs (≤5%):

Headache (7%)
Dry mouth (3%)
Fatigue (2%)
Pharyngitis (2%)

Rare Serious Effects:

QT prolongation (with overdose)
Hypersensitivity reactions
Elevated liver enzymes

8. Pharmacokinetic Highlights

Bioavailability: ~85%
Protein binding: 83-87%
Half-life: 27 hours (permits once-daily dosing)
Metabolism: Hepatic (CYP3A4/2C8)
Excretion: Urine (40%) and feces (56%)

9. Comparative Advantages

Parameter	Desloratadine	Loratadine
Potency	2-4× higher	Baseline
Onset	Faster	Slower
Drug interactions	Fewer	Moderate
Cost	Higher	Lower

10. Important Precautions

⚠ Contraindications:

Hypersensitivity to loratadine/desloratadine
Severe hepatic impairment

⚠ Special Populations:

Pregnancy: Category C (use cautiously)
Lactation: Excreted in milk (consider alternatives)

⚠ Drug Interactions:

Erythromycin/ketoconazole: Increase desloratadine levels
CNS depressants: Minimal interaction

11. Storage Requirements

Store at 15-30°C
Protect from light/moisture
Oral solution: Stable for 28 days after opening

12. Clinical Pearls

• Superior to loratadine for:

Nasal congestion relief
Chronic urticaria management
• Preferred choice for:
Patients with hepatic impairment
Those requiring minimal sedation
• Cost-benefit: Consider for patients unresponsive to loratadine

13. Conclusion

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

1. Introduction

2. Key Specifications

Generic Name: Desloratadine
Brand Names: D-Loratin (India), Aerius/Clarinex (international)
Dosage Forms:
- Tablets (5 mg)
- Oral solution (2.5 mg/5 mL)
- Dispersible tablets
Manufacturer: Cipla (D-Loratin brand)

3. Therapeutic Advantages

✔ 2-4× more potent than loratadine
✔ Non-sedating at recommended doses
✔ 24-hour duration with single daily dosing
✔ Additional anti-inflammatory properties

4. Mechanism of Action

Selective peripheral H1-receptor inverse agonist
Inhibits:
- Histamine release from mast cells
- Cytokine production (IL-4, IL-6, IL-13)
- ICAM-1 expression
Minimal CNS penetration (brain/blood ratio <0.03)

5. Approved Indications

Allergic rhinitis (seasonal/perennial)
Chronic idiopathic urticaria
Allergic conjunctivitis (off-label)
Atopic dermatitis (adjunct therapy)

6. Dosage & Administration

Standard Dosing:

Adults/Adolescents (≥12 yrs): 5 mg once daily
Children (6-11 yrs): 2.5 mg once daily
Children (1-5 yrs): 1.25 mg once daily
Renal/hepatic impairment: No adjustment typically needed

Special Notes:

May take with/without food
Onset within 1-3 hours
Peak effect at 3-6 hours

7. Safety Profile

Common ADRs (≤5%):

Headache (7%)
Dry mouth (3%)
Fatigue (2%)
Pharyngitis (2%)

Rare Serious Effects:

QT prolongation (with overdose)
Hypersensitivity reactions
Elevated liver enzymes

8. Pharmacokinetic Highlights

Bioavailability: ~85%
Protein binding: 83-87%
Half-life: 27 hours (permits once-daily dosing)
Metabolism: Hepatic (CYP3A4/2C8)
Excretion: Urine (40%) and feces (56%)

9. Comparative Advantages

Parameter	Desloratadine	Loratadine
Potency	2-4× higher	Baseline
Onset	Faster	Slower
Drug interactions	Fewer	Moderate
Cost	Higher	Lower

10. Important Precautions

⚠ Contraindications:

Hypersensitivity to loratadine/desloratadine
Severe hepatic impairment

⚠ Special Populations:

Pregnancy: Category C (use cautiously)
Lactation: Excreted in milk (consider alternatives)

⚠ Drug Interactions:

Erythromycin/ketoconazole: Increase desloratadine levels
CNS depressants: Minimal interaction

11. Storage Requirements

Store at 15-30°C
Protect from light/moisture
Oral solution: Stable for 28 days after opening

12. Clinical Pearls

• Superior to loratadine for:

Nasal congestion relief
Chronic urticaria management
• Preferred choice for:
Patients with hepatic impairment
Those requiring minimal sedation
• Cost-benefit: Consider for patients unresponsive to loratadine

13. Conclusion

Reviews

There are no reviews yet.

Be the first to review “D-LORATIN”

Description
Reviews (0)

1. Introduction

2. Key Specifications

Generic Name: Desloratadine
Brand Names: D-Loratin (India), Aerius/Clarinex (international)
Dosage Forms:
- Tablets (5 mg)
- Oral solution (2.5 mg/5 mL)
- Dispersible tablets
Manufacturer: Cipla (D-Loratin brand)

3. Therapeutic Advantages

✔ 2-4× more potent than loratadine
✔ Non-sedating at recommended doses
✔ 24-hour duration with single daily dosing
✔ Additional anti-inflammatory properties

4. Mechanism of Action

Selective peripheral H1-receptor inverse agonist
Inhibits:
- Histamine release from mast cells
- Cytokine production (IL-4, IL-6, IL-13)
- ICAM-1 expression
Minimal CNS penetration (brain/blood ratio <0.03)

5. Approved Indications

Allergic rhinitis (seasonal/perennial)
Chronic idiopathic urticaria
Allergic conjunctivitis (off-label)
Atopic dermatitis (adjunct therapy)

6. Dosage & Administration

Standard Dosing:

Adults/Adolescents (≥12 yrs): 5 mg once daily
Children (6-11 yrs): 2.5 mg once daily
Children (1-5 yrs): 1.25 mg once daily
Renal/hepatic impairment: No adjustment typically needed

Special Notes:

May take with/without food
Onset within 1-3 hours
Peak effect at 3-6 hours

7. Safety Profile

Common ADRs (≤5%):

Headache (7%)
Dry mouth (3%)
Fatigue (2%)
Pharyngitis (2%)

Rare Serious Effects:

QT prolongation (with overdose)
Hypersensitivity reactions
Elevated liver enzymes

8. Pharmacokinetic Highlights

Bioavailability: ~85%
Protein binding: 83-87%
Half-life: 27 hours (permits once-daily dosing)
Metabolism: Hepatic (CYP3A4/2C8)
Excretion: Urine (40%) and feces (56%)

9. Comparative Advantages

Parameter	Desloratadine	Loratadine
Potency	2-4× higher	Baseline
Onset	Faster	Slower
Drug interactions	Fewer	Moderate
Cost	Higher	Lower

10. Important Precautions

⚠ Contraindications:

Hypersensitivity to loratadine/desloratadine
Severe hepatic impairment

⚠ Special Populations:

Pregnancy: Category C (use cautiously)
Lactation: Excreted in milk (consider alternatives)

⚠ Drug Interactions:

Erythromycin/ketoconazole: Increase desloratadine levels
CNS depressants: Minimal interaction

11. Storage Requirements

Store at 15-30°C
Protect from light/moisture
Oral solution: Stable for 28 days after opening

12. Clinical Pearls

• Superior to loratadine for:

Nasal congestion relief
Chronic urticaria management
• Preferred choice for:
Patients with hepatic impairment
Those requiring minimal sedation
• Cost-benefit: Consider for patients unresponsive to loratadine

13. Conclusion

Reviews

There are no reviews yet.

Be the first to review “D-LORATIN”

Medical Disclaimer

Anteka Pharmacy primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on Anteka Pharmacy. Our mission is to support, not replace, the doctor-patient relationship.