U-TRYP 10000 is a high-potency proteolytic enzyme combination containing trypsin and chymotrypsin with enhanced anti-inflammatory and wound-healing properties.
2. Key Specifications
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Active Ingredients:
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Trypsin 100mg
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Chymotrypsin 8mg
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(Equivalent to 10,000 USP units)
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Dosage Form:Â Enteric-coated tablets
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Class:Â Serine protease enzyme combination
3. Therapeutic Advantages
✔ 2x potency of standard U-TRYP 5000
✔ Dual-action on inflammation and healing
✔ No GI irritation (enteric-coated)
✔ Synergizes with antibiotics
4. Mechanism of Action
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Trypsin:
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Degrades necrotic tissue
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Reduces bradykinin and prostaglandins
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Chymotrypsin:
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Breaks down fibrinogen
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Modulates cytokines (IL-6, TNF-α)
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Combined Effect:
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40% faster edema resolution
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35% better pain control vs placebo
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5. Approved Indications
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Post-surgical recovery (orthopedic, dental, cosmetic)
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Severe trauma (fractures, soft tissue injuries)
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Chronic inflammation (bursitis, tendinitis)
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Venous stasis ulcers
6. Dosage & Administration
Standard Regimen:
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Adults:Â 1 tablet TID (before meals)
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Acute cases:Â 2 tablets TID for 3-5 days
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Maintenance:Â 1 tablet BID
Special Protocols:
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Pre-op:Â Start 48hrs before surgery
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Post-op:Â Continue for 7-10 days
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Trauma:Â Use until swelling subsides
7. Safety Profile
Common (1-3%):
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Mild nausea (if coating damaged)
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Rare hypersensitivity
Advantages Over NSAIDs:
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No bleeding risk
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No renal toxicity
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Safe for elderly
8. Pharmacokinetics
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Absorption:Â Small intestine (pH-dependent)
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Peak Activity:Â 2-4 hours
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Duration:Â 8-12 hours
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Excretion:Â Renal (inactive metabolites)
9. Clinical Comparison: U-TRYP 5000 vs 10000
Parameter | U-TRYP 5000 | U-TRYP 10000 |
---|---|---|
Potency | Base | 2× |
Dose Frequency | TID-QID | BID-TID |
Cost/Day | ₹25-30 | ₹40-45 |
Best For | Mild cases | Severe inflammation |
10. Important Precautions
âš Â Contraindications:
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Active hemorrhage
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Severe liver cirrhosis
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Known protease allergy
âš Â Special Populations:
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Pregnancy: Category C (limited data)
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Children: Not studied <12 years
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Elderly: No adjustment needed
âš Â Drug Interactions:
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Anticoagulants: Theoretical synergy
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Antibiotics: Enhanced tissue penetration
11. Storage Requirements
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Temperature: Below 25°C
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Humidity:Â <60% RH
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Stability:Â 36 months in sealed blisters
12. Patient Counseling
• “Swallow whole with water”
• “Take 30min before meals”
• “Report any skin rash immediately”
• “Continue full course for best results”
13. Conclusion
U-TRYP 10000 delivers enhanced anti-inflammatory efficacy for demanding clinical situations, combining proven safety with twice the potency of standard preparations. Its unique mechanism makes it particularly valuable when NSAIDs are contraindicated or insufficient.
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