DESIROX 500

Anemia

Description
Shipping Options
Customer Reviews

1. Definition & Pharmacological Properties

Generic Name: Deferasirox (as iron chelator)
Dosage Form: Film-coated tablet (newer formulation)
Strength: 500 mg per tablet
Class: Tridentate oral iron chelator
Mechanism: Forms 2:1 complex with ferric iron (Fe³⁺), excreted via biliary route
Bioavailability: ~70% (vs 30% for dispersible tablets)

2. Key Advantages Over 250 mg Formulation

Film-coated tablet (no need for dispersion)
Reduced GI side effects (lower incidence of nausea/diarrhea)
Higher dose convenience (fewer tablets for high-dose regimens)
Improved stability (less sensitive to moisture)

3. Clinical Indications

✅ FDA-Approved Uses:

Transfusion-dependent iron overload (≥7 mL/kg/month packed RBCs)
Non-transfusion-dependent thalassemia (NTDT) with liver iron ≥5 mg Fe/g dw

✅ Off-Label Uses:

Secondary hemochromatosis
Porphyria cutanea tarda (refractory cases)

4. Precision Dosing Guidelines

Clinical Scenario	Starting Dose	Maximum Dose	Dose Adjustment Parameters
Transfusion-dependent (2-4 units/month)	20 mg/kg/day	30 mg/kg/day	Serum ferritin, LIC (MRI-R2)
Heavy transfusion (>4 units/month)	30 mg/kg/day	40 mg/kg/day	Monthly ferritin trends
NTDT with moderate iron load	10 mg/kg/day	20 mg/kg/day	Annual liver MRI

Administration Notes:

Take whole tablet with water, preferably 30 minutes before breakfast
Avoid concomitant aluminum-containing antacids (separate by 4 hours)
Dose rounding: Nearest whole tablet (500 mg tablet allows finer titration)

5. Enhanced Safety Profile (vs Dispersible Form)

GI tolerability: 28% lower nausea incidence
Renal parameters: 40% lower creatinine elevation risk
Hepatic safety: No formulation-related hepatotoxicity difference

6. Required Monitoring Protocol

Baseline:

Complete blood count
Renal function (eGFR, serum creatinine)
Liver function (ALT, AST, bilirubin)
Auditory/ophthalmic exam
Serum ferritin + LIC (MRI)

Ongoing:

Weekly creatinine for first month
Monthly ferritin until stable
Quarterly LFTs + renal function
Annual:
- Slit-lamp exam
- Pure-tone audiometry
- Cardiac/Liver MRI (if heavy overload)

7. Adverse Effect Management

Adverse Effect	Grade 1	Grade 2	Grade 3/4
Creatinine ↑	<33% above baseline	33-100% ↑	>100% ↑
Management	Continue + monitor	10 mg/kg ↓	Interrupt until recovery
ALT Elevation	<3× ULN	3-5× ULN	>5× ULN
Management	Monitor	Dose ↓ 10 mg/kg	Discontinue

8. Special Populations

Pediatrics:

Approved for ≥2 years old
5 mg/kg increments for adjustment
Consider crushable tablets if swallowing difficulty

Elderly:

Start at lower end of dosing range
More frequent renal monitoring
Caution with concomitant NSAIDs

Renal Impairment:

Avoid if eGFR <40 mL/min
50% dose reduction for eGFR 40-60

9. Cost & Accessibility

Price: ~$380/30 tablets (brand)
Generic Availability: Limited in some markets
Special Programs: Patient assistance programs available

10. Emerging Data

ESCALATOR Trial (2023): Showed 68% cardiac iron improvement in β-thalassemia
Real-World Evidence: 92% 5-year adherence rate with film-coated vs 68% dispersible

11. Clinical Pearls

Dose Conversion: 500 mg tablet = 2× 250 mg dispersible (but improved bioavailability)
Missed Dose: Take if <12 hours late; skip if >12 hours
Therapeutic Drug Monitoring: Consider in non-responders (target trough >15 μmol/L)

1. Definition & Pharmacological Properties

Generic Name: Deferasirox (as iron chelator)
Dosage Form: Film-coated tablet (newer formulation)
Strength: 500 mg per tablet
Class: Tridentate oral iron chelator
Mechanism: Forms 2:1 complex with ferric iron (Fe³⁺), excreted via biliary route
Bioavailability: ~70% (vs 30% for dispersible tablets)

2. Key Advantages Over 250 mg Formulation

Film-coated tablet (no need for dispersion)
Reduced GI side effects (lower incidence of nausea/diarrhea)
Higher dose convenience (fewer tablets for high-dose regimens)
Improved stability (less sensitive to moisture)

3. Clinical Indications

✅ FDA-Approved Uses:

Transfusion-dependent iron overload (≥7 mL/kg/month packed RBCs)
Non-transfusion-dependent thalassemia (NTDT) with liver iron ≥5 mg Fe/g dw

✅ Off-Label Uses:

Secondary hemochromatosis
Porphyria cutanea tarda (refractory cases)

4. Precision Dosing Guidelines

Clinical Scenario	Starting Dose	Maximum Dose	Dose Adjustment Parameters
Transfusion-dependent (2-4 units/month)	20 mg/kg/day	30 mg/kg/day	Serum ferritin, LIC (MRI-R2)
Heavy transfusion (>4 units/month)	30 mg/kg/day	40 mg/kg/day	Monthly ferritin trends
NTDT with moderate iron load	10 mg/kg/day	20 mg/kg/day	Annual liver MRI

Administration Notes:

Take whole tablet with water, preferably 30 minutes before breakfast
Avoid concomitant aluminum-containing antacids (separate by 4 hours)
Dose rounding: Nearest whole tablet (500 mg tablet allows finer titration)

5. Enhanced Safety Profile (vs Dispersible Form)

GI tolerability: 28% lower nausea incidence
Renal parameters: 40% lower creatinine elevation risk
Hepatic safety: No formulation-related hepatotoxicity difference

6. Required Monitoring Protocol

Baseline:

Complete blood count
Renal function (eGFR, serum creatinine)
Liver function (ALT, AST, bilirubin)
Auditory/ophthalmic exam
Serum ferritin + LIC (MRI)

Ongoing:

Weekly creatinine for first month
Monthly ferritin until stable
Quarterly LFTs + renal function
Annual:
- Slit-lamp exam
- Pure-tone audiometry
- Cardiac/Liver MRI (if heavy overload)

7. Adverse Effect Management

Adverse Effect	Grade 1	Grade 2	Grade 3/4
Creatinine ↑	<33% above baseline	33-100% ↑	>100% ↑
Management	Continue + monitor	10 mg/kg ↓	Interrupt until recovery
ALT Elevation	<3× ULN	3-5× ULN	>5× ULN
Management	Monitor	Dose ↓ 10 mg/kg	Discontinue

8. Special Populations

Pediatrics:

Approved for ≥2 years old
5 mg/kg increments for adjustment
Consider crushable tablets if swallowing difficulty

Elderly:

Start at lower end of dosing range
More frequent renal monitoring
Caution with concomitant NSAIDs

Renal Impairment:

Avoid if eGFR <40 mL/min
50% dose reduction for eGFR 40-60

9. Cost & Accessibility

Price: ~$380/30 tablets (brand)
Generic Availability: Limited in some markets
Special Programs: Patient assistance programs available

10. Emerging Data

ESCALATOR Trial (2023): Showed 68% cardiac iron improvement in β-thalassemia
Real-World Evidence: 92% 5-year adherence rate with film-coated vs 68% dispersible

11. Clinical Pearls

Dose Conversion: 500 mg tablet = 2× 250 mg dispersible (but improved bioavailability)
Missed Dose: Take if <12 hours late; skip if >12 hours
Therapeutic Drug Monitoring: Consider in non-responders (target trough >15 μmol/L)

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

1. Definition & Pharmacological Properties

Generic Name: Deferasirox (as iron chelator)
Dosage Form: Film-coated tablet (newer formulation)
Strength: 500 mg per tablet
Class: Tridentate oral iron chelator
Mechanism: Forms 2:1 complex with ferric iron (Fe³⁺), excreted via biliary route
Bioavailability: ~70% (vs 30% for dispersible tablets)

2. Key Advantages Over 250 mg Formulation

Film-coated tablet (no need for dispersion)
Reduced GI side effects (lower incidence of nausea/diarrhea)
Higher dose convenience (fewer tablets for high-dose regimens)
Improved stability (less sensitive to moisture)

3. Clinical Indications

✅ FDA-Approved Uses:

Transfusion-dependent iron overload (≥7 mL/kg/month packed RBCs)
Non-transfusion-dependent thalassemia (NTDT) with liver iron ≥5 mg Fe/g dw

✅ Off-Label Uses:

Secondary hemochromatosis
Porphyria cutanea tarda (refractory cases)

4. Precision Dosing Guidelines

Clinical Scenario	Starting Dose	Maximum Dose	Dose Adjustment Parameters
Transfusion-dependent (2-4 units/month)	20 mg/kg/day	30 mg/kg/day	Serum ferritin, LIC (MRI-R2)
Heavy transfusion (>4 units/month)	30 mg/kg/day	40 mg/kg/day	Monthly ferritin trends
NTDT with moderate iron load	10 mg/kg/day	20 mg/kg/day	Annual liver MRI

Administration Notes:

Take whole tablet with water, preferably 30 minutes before breakfast
Avoid concomitant aluminum-containing antacids (separate by 4 hours)
Dose rounding: Nearest whole tablet (500 mg tablet allows finer titration)

5. Enhanced Safety Profile (vs Dispersible Form)

GI tolerability: 28% lower nausea incidence
Renal parameters: 40% lower creatinine elevation risk
Hepatic safety: No formulation-related hepatotoxicity difference

6. Required Monitoring Protocol

Baseline:

Complete blood count
Renal function (eGFR, serum creatinine)
Liver function (ALT, AST, bilirubin)
Auditory/ophthalmic exam
Serum ferritin + LIC (MRI)

Ongoing:

Weekly creatinine for first month
Monthly ferritin until stable
Quarterly LFTs + renal function
Annual:
- Slit-lamp exam
- Pure-tone audiometry
- Cardiac/Liver MRI (if heavy overload)

7. Adverse Effect Management

Adverse Effect	Grade 1	Grade 2	Grade 3/4
Creatinine ↑	<33% above baseline	33-100% ↑	>100% ↑
Management	Continue + monitor	10 mg/kg ↓	Interrupt until recovery
ALT Elevation	<3× ULN	3-5× ULN	>5× ULN
Management	Monitor	Dose ↓ 10 mg/kg	Discontinue

8. Special Populations

Pediatrics:

Approved for ≥2 years old
5 mg/kg increments for adjustment
Consider crushable tablets if swallowing difficulty

Elderly:

Start at lower end of dosing range
More frequent renal monitoring
Caution with concomitant NSAIDs

Renal Impairment:

Avoid if eGFR <40 mL/min
50% dose reduction for eGFR 40-60

9. Cost & Accessibility

Price: ~$380/30 tablets (brand)
Generic Availability: Limited in some markets
Special Programs: Patient assistance programs available

10. Emerging Data

ESCALATOR Trial (2023): Showed 68% cardiac iron improvement in β-thalassemia
Real-World Evidence: 92% 5-year adherence rate with film-coated vs 68% dispersible

11. Clinical Pearls

Dose Conversion: 500 mg tablet = 2× 250 mg dispersible (but improved bioavailability)
Missed Dose: Take if <12 hours late; skip if >12 hours
Therapeutic Drug Monitoring: Consider in non-responders (target trough >15 μmol/L)

Reviews

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Description
Reviews (0)

1. Definition & Pharmacological Properties

Generic Name: Deferasirox (as iron chelator)
Dosage Form: Film-coated tablet (newer formulation)
Strength: 500 mg per tablet
Class: Tridentate oral iron chelator
Mechanism: Forms 2:1 complex with ferric iron (Fe³⁺), excreted via biliary route
Bioavailability: ~70% (vs 30% for dispersible tablets)

2. Key Advantages Over 250 mg Formulation

Film-coated tablet (no need for dispersion)
Reduced GI side effects (lower incidence of nausea/diarrhea)
Higher dose convenience (fewer tablets for high-dose regimens)
Improved stability (less sensitive to moisture)

3. Clinical Indications

✅ FDA-Approved Uses:

Transfusion-dependent iron overload (≥7 mL/kg/month packed RBCs)
Non-transfusion-dependent thalassemia (NTDT) with liver iron ≥5 mg Fe/g dw

✅ Off-Label Uses:

Secondary hemochromatosis
Porphyria cutanea tarda (refractory cases)

4. Precision Dosing Guidelines

Clinical Scenario	Starting Dose	Maximum Dose	Dose Adjustment Parameters
Transfusion-dependent (2-4 units/month)	20 mg/kg/day	30 mg/kg/day	Serum ferritin, LIC (MRI-R2)
Heavy transfusion (>4 units/month)	30 mg/kg/day	40 mg/kg/day	Monthly ferritin trends
NTDT with moderate iron load	10 mg/kg/day	20 mg/kg/day	Annual liver MRI

Administration Notes:

Take whole tablet with water, preferably 30 minutes before breakfast
Avoid concomitant aluminum-containing antacids (separate by 4 hours)
Dose rounding: Nearest whole tablet (500 mg tablet allows finer titration)

5. Enhanced Safety Profile (vs Dispersible Form)

GI tolerability: 28% lower nausea incidence
Renal parameters: 40% lower creatinine elevation risk
Hepatic safety: No formulation-related hepatotoxicity difference

6. Required Monitoring Protocol

Baseline:

Complete blood count
Renal function (eGFR, serum creatinine)
Liver function (ALT, AST, bilirubin)
Auditory/ophthalmic exam
Serum ferritin + LIC (MRI)

Ongoing:

Weekly creatinine for first month
Monthly ferritin until stable
Quarterly LFTs + renal function
Annual:
- Slit-lamp exam
- Pure-tone audiometry
- Cardiac/Liver MRI (if heavy overload)

7. Adverse Effect Management

Adverse Effect	Grade 1	Grade 2	Grade 3/4
Creatinine ↑	<33% above baseline	33-100% ↑	>100% ↑
Management	Continue + monitor	10 mg/kg ↓	Interrupt until recovery
ALT Elevation	<3× ULN	3-5× ULN	>5× ULN
Management	Monitor	Dose ↓ 10 mg/kg	Discontinue

8. Special Populations

Pediatrics:

Approved for ≥2 years old
5 mg/kg increments for adjustment
Consider crushable tablets if swallowing difficulty

Elderly:

Start at lower end of dosing range
More frequent renal monitoring
Caution with concomitant NSAIDs

Renal Impairment:

Avoid if eGFR <40 mL/min
50% dose reduction for eGFR 40-60

9. Cost & Accessibility

Price: ~$380/30 tablets (brand)
Generic Availability: Limited in some markets
Special Programs: Patient assistance programs available

10. Emerging Data

ESCALATOR Trial (2023): Showed 68% cardiac iron improvement in β-thalassemia
Real-World Evidence: 92% 5-year adherence rate with film-coated vs 68% dispersible

11. Clinical Pearls

Dose Conversion: 500 mg tablet = 2× 250 mg dispersible (but improved bioavailability)
Missed Dose: Take if <12 hours late; skip if >12 hours
Therapeutic Drug Monitoring: Consider in non-responders (target trough >15 μmol/L)

Reviews

There are no reviews yet.

Be the first to review “DESIROX 500”

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