GENERIC DEFERASIROX 100MG

Definition

Deferasirox (100mg tablet) is an oral iron chelator used to treat chronic iron overload caused by repeated blood transfusions in conditions like:

• Thalassemia

• Sickle cell disease

• Myelodysplastic syndromes (MDS)

• Other transfusion-dependent anemias

It works by binding excess iron in the body and promoting its excretion, preventing organ damage.

Importance

• Prevents iron toxicity (Excess iron from transfusions can damage the liver, heart, and endocrine organs.)

• Reduces risk of organ failure (Liver cirrhosis, heart disease, diabetes due to iron overload)

• Improves survival in transfusion-dependent patients

Use

• Treatment of chronic iron overload (due to long-term blood transfusions)

• Not for anemia treatment (It removes iron; it does not increase hemoglobin.)

• Dosage: Usually 10–30 mg/kg once daily, adjusted based on serum ferritin levels.

Side Effects

Common:

• Nausea, vomiting, diarrhea

• Abdominal pain

• Skin rash

• Headache

• Increased liver enzymes

Serious (Require Medical Attention):

• Kidney dysfunction (↑ creatinine)

• Liver toxicity (jaundice, elevated ALT/AST)

• Gastrointestinal bleeding (rare)

• Hearing loss/vision changes (rare)

Storage

• Store at 20–25°C (room temperature)

• Keep in original packaging (protects from moisture)

• Keep away from children (accidental overdose can be harmful)

Conclusion

Deferasirox 100mg tablet is a life-saving drug for patients with iron overload from frequent transfusions. While effective, it requires regular monitoring (kidney/liver function tests, serum ferritin) to balance efficacy and safety. Always take as prescribed and report any unusual symptoms to a doctor.