Definition:
RELISEAL is a long-acting topical/local anaesthetic formulation, typically combining Lidocaine with advanced delivery agents (e.g., liposomal or polymer-based technology) for prolonged numbing effects.
INTRODUCTION
Used for extended-duration pain control, RELISEAL is ideal for:
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Post-surgical wound care (e.g., burns, grafts).
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Chronic pain management (neuropathy, shingles).
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Procedural anaesthesia (lumbar punctures, long dermatologic procedures).
Unlike traditional anaesthetics, it provides 6–12 hours of analgesia per application.
DESCRIPTION
Active Ingredients:
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Lidocaine (3–5%) – Rapid onset.
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Adjuncts:
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Tetracaine (1–2%) – Extends duration.
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Liposomal encapsulation – Enhances skin penetration and delays absorption.
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Formulations:
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Cream/Gel – For intact skin.
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Patches – For targeted, controlled release (e.g., post-herpetic neuralgia).
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Injectable depot (under development) – For surgical site infiltration.
Pharmacokinetics:
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Onset: 15–30 minutes (topical); faster if mucosa is treated.
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Duration: 6–12 hours (vs. 1–2 hours for standard lidocaine).
USES
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Surgical Aftercare:
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Reduces opioid needs post-operatively.
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Chronic Conditions:
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Diabetic neuropathy, post-mastectomy pain.
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Dermatology:
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Laser resurfacing, tattoo removal.
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Pediatrics:
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Painless dressing changes for burns.
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SIDE EFFECTS
Common:
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Local erythema or edema (mild, resolves quickly).
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Temporary numbness beyond treatment area.
Serious (Rare):
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Contact dermatitis (with prolonged patch use).
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Systemic toxicity (if applied to large broken skin areas):
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Blurred vision, arrhythmias.
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IMPORTANCE
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Reduces reliance on opioids for post-procedural pain.
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Patient-friendly – Fewer reapplications needed.
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Cost-effective for long-duration needs.
STORAGE
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Refrigerate (2–8°C) if liposomal; room temp for others.
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Avoid freezing or humidity.
CONCLUSION
RELISEAL bridges the gap between short-acting locals and systemic analgesics, offering safer, sustained relief. Ideal for outpatient procedures and chronic pain, but requires monitoring for skin reactions.
Contraindications:
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Open wounds (unless formulated for mucosa).
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History of local anaesthetic allergy.
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