Definition:
VIBRO 10mg Injection is a local anesthetic formulation containing Bupivacaine Hydrochloride (10mg/mL), designed for long-duration nerve blocks and surgical anesthesia.
INTRODUCTION
VIBRO is used for:
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Regional anesthesia (epidural, spinal, peripheral nerve blocks).
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Post-operative pain relief (up to 12 hours of analgesia).
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Labor analgesia (low-dose epidurals).
It belongs to the amide-class of anesthetics, offering prolonged numbness compared to lidocaine.
DESCRIPTION
Composition:
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Bupivacaine HCl (10mg/mL) – Potent, long-acting sodium channel blocker.
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Preservatives: Methylparaben (in multi-dose vials).
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pH-adjusted (3.5–5.5) for stability.
Key Properties:
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Onset: 15–30 minutes (slower than lidocaine).
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Duration: 4–12 hours (depends on administration route).
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Motor vs. Sensory Block: Selective sensory blockade at low doses.
USES
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Surgical Anesthesia:
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Cesarean sections (spinal/epidural).
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Orthopedic surgeries (knee/shoulder blocks).
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Pain Management:
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Post-thoracotomy pain (intercostal blocks).
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Chronic pain (nerve root injections).
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Obstetrics:
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Labor epidurals (0.0625–0.125% diluted solutions).
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SIDE EFFECTS
Common:
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Hypotension (epidural/spinal use).
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Numbness beyond target area (e.g., leg weakness with epidural).
Serious:
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Cardiotoxicity (arrhythmias, cardiac arrest – avoid IV injection).
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Neurologic toxicity (seizures, if systemic absorption exceeds threshold).
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Allergic reactions (rare with amides).
ADVANTAGES OVER LIDOCAINE
Feature | VIBRO (Bupivacaine) | Lidocaine |
---|---|---|
Duration | 4–12 hrs | 0.5–2 hrs |
Potency | 4x stronger | Baseline |
Cardiac Risk | High (narrow therapeutic index) | Low |
DOSING GUIDELINES
Route | Dose (Max) | Onset | Duration |
---|---|---|---|
Epidural | 10–20mg (75mg max) | 15–30 min | 4–8 hrs |
Spinal | 5–15mg | 5–10 min | 3–6 hrs |
Nerve Block | 2.5–5mg/mL (up to 175mg) | 20 min | 8–12 hrs |
Note: Never exceed 2mg/kg (or 175mg total) due to cardiotoxicity risk.
STORAGE
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Room temperature (below 25°C).
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Single-dose vials: Discard unused portions (no preservatives).
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Protect from light (store in original packaging).
CONTRAINDICATIONS
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Hypersensitivity to amide anesthetics.
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Severe cardiac disease (risk of arrhythmias).
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Septicemia (for neuraxial blocks).
CONCLUSION
VIBRO 10mg Injection is indispensable for prolonged surgical anesthesia but requires:
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Expert administration (avoid intravascular injection).
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Cardiac monitoring in high-risk patients.
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Dose precision to avoid systemic toxicity.
Alternatives: For shorter procedures, consider lidocaine/ropivacaine.
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