CILAXIN

Antibacterial

Description
Shipping Options
Customer Reviews

CILAXIN is a potent broad-spectrum antibiotic combining Imipenem (a carbapenem) and Cilastatin (a renal enzyme inhibitor). It is used for severe, multidrug-resistant (MDR) bacterial infections, particularly in hospital-acquired infections (HAIs).

Composition

Active Ingredients:
- Imipenem (500 mg or 1 g) – A carbapenem antibiotic with bactericidal activity.
- Cilastatin (500 mg or 1 g) – Protects Imipenem from breakdown in kidneys.
Excipients: Sodium bicarbonate (for pH adjustment).

Mechanism of Action

Imipenem:
- Binds to penicillin-binding proteins (PBPs), disrupting bacterial cell wall synthesis.
- Covers Gram-positive, Gram-negative, and anaerobic bacteria, including ESBL and AmpC producers.
Cilastatin:
- Blocks renal dehydropeptidase-I, preventing Imipenem degradation and increasing its efficacy.

Spectrum of Activity

✅ Gram-positive: Staphylococcus aureus (MSSA), Streptococcus spp. ✅ Gram-negative: E. coli, Klebsiella, Pseudomonas aeruginosa, Acinetobacter ✅ Anaerobes: Bacteroides fragilis ❌ Not effective against: MRSA, Stenotrophomonas maltophilia, Enterococcus faecium (VRE)

Dosage & Administration

Standard Adult Dose:

Moderate infections: 500 mg IV every 6 hours.
Severe infections: 1 g IV every 6–8 hours.
Max daily dose: 4 g.

Infusion Guidelines:

Reconstitute with 10 mL sterile water (for 500 mg or 1 g vial).
Further dilute in 100 mL NS/D5W.
Infuse over 30–40 minutes.

Dosage Adjustments:

Renal impairment (CrCl <30 mL/min):
- CrCl 15–30: 500 mg every 8–12 hours.
- CrCl <15: 250–500 mg every 12 hours.
Hemodialysis: Administer after dialysis.

Pediatric Dose:

Children ≥3 months: 15–25 mg/kg every 6 hours (max 4 g/day).

Uses (Indications)

Severe intra-abdominal infections
Hospital-acquired pneumonia (HAP/VAP)
Complicated UTIs (pyelonephritis)
Septicemia & endocarditis
Bone/joint infections (osteomyelitis)
Febrile neutropenia (empiric therapy)

Storage & Stability

Unreconstituted powder: Store at 20–25°C, protect from moisture.
Reconstituted solution:
- Stable for 4 hours at room temp or 24 hours if refrigerated (2–8°C).
Do not freeze.

Key Recommendations

✔ Reserve for severe MDR infections (risk of resistance). ✔ Monitor renal function (adjust dose in kidney disease). ✔ Watch for seizures (high risk in renal impairment, CNS disorders). ✔ Avoid in penicillin allergy (cross-reactivity possible).

Important Notes

⚠ Seizure Risk: Higher in renal impairment, CNS disorders, or overdose. ⚠ C. difficile Risk: May cause pseudomembranous colitis (monitor diarrhea). ⚠ Pregnancy (Category C): Use only if benefits outweigh risks. ⚠ Resistance Alert: Overuse leads to CRE (carbapenem-resistant Enterobacteriaceae).

Comparison with Other Carbapenems

Feature	CILAXIN (Imipenem)	Meropenem	Ertapenem
Pseudomonas Coverage	✓	✓	✗
Dosing Frequency	q6h	q8h	q24h
CNS Penetration	Moderate	Excellent	Poor
Seizure Risk	High	Low	Lowest

Conclusion

CILAXIN is a last-line antibiotic for life-threatening MDR infections. Strict antimicrobial stewardship is crucial to prevent resistance.

Composition

Active Ingredients:
- Imipenem (500 mg or 1 g) – A carbapenem antibiotic with bactericidal activity.
- Cilastatin (500 mg or 1 g) – Protects Imipenem from breakdown in kidneys.
Excipients: Sodium bicarbonate (for pH adjustment).

Mechanism of Action

Imipenem:
- Binds to penicillin-binding proteins (PBPs), disrupting bacterial cell wall synthesis.
- Covers Gram-positive, Gram-negative, and anaerobic bacteria, including ESBL and AmpC producers.
Cilastatin:
- Blocks renal dehydropeptidase-I, preventing Imipenem degradation and increasing its efficacy.

Spectrum of Activity

✅ Gram-positive: Staphylococcus aureus (MSSA), Streptococcus spp.
✅ Gram-negative: E. coli, Klebsiella, Pseudomonas aeruginosa, Acinetobacter
✅ Anaerobes: Bacteroides fragilis
❌ Not effective against: MRSA, Stenotrophomonas maltophilia, Enterococcus faecium (VRE)

Dosage & Administration

Standard Adult Dose:

Moderate infections: 500 mg IV every 6 hours.
Severe infections: 1 g IV every 6–8 hours.
Max daily dose: 4 g.

Infusion Guidelines:

Reconstitute with 10 mL sterile water (for 500 mg or 1 g vial).
Further dilute in 100 mL NS/D5W.
Infuse over 30–40 minutes.

Dosage Adjustments:

Renal impairment (CrCl <30 mL/min):
- CrCl 15–30: 500 mg every 8–12 hours.
- CrCl <15: 250–500 mg every 12 hours.
Hemodialysis: Administer after dialysis.

Pediatric Dose:

Children ≥3 months: 15–25 mg/kg every 6 hours (max 4 g/day).

Uses (Indications)

Severe intra-abdominal infections
Hospital-acquired pneumonia (HAP/VAP)
Complicated UTIs (pyelonephritis)
Septicemia & endocarditis
Bone/joint infections (osteomyelitis)
Febrile neutropenia (empiric therapy)

Storage & Stability

Unreconstituted powder: Store at 20–25°C, protect from moisture.
Reconstituted solution:
- Stable for 4 hours at room temp or 24 hours if refrigerated (2–8°C).
Do not freeze.

Key Recommendations

✔ Reserve for severe MDR infections (risk of resistance).
✔ Monitor renal function (adjust dose in kidney disease).
✔ Watch for seizures (high risk in renal impairment, CNS disorders).
✔ Avoid in penicillin allergy (cross-reactivity possible).

Important Notes

⚠ Seizure Risk: Higher in renal impairment, CNS disorders, or overdose.
⚠ C. difficile Risk: May cause pseudomembranous colitis (monitor diarrhea).
⚠ Pregnancy (Category C): Use only if benefits outweigh risks.
⚠ Resistance Alert: Overuse leads to CRE (carbapenem-resistant Enterobacteriaceae).

Comparison with Other Carbapenems

Feature	CILAXIN (Imipenem)	Meropenem	Ertapenem
Pseudomonas Coverage	✓	✓	✗
Dosing Frequency	q6h	q8h	q24h
CNS Penetration	Moderate	Excellent	Poor
Seizure Risk	High	Low	Lowest

Conclusion

CILAXIN is a last-line antibiotic for life-threatening MDR infections. Strict antimicrobial stewardship is crucial to prevent resistance.

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Composition

Active Ingredients:
- Imipenem (500 mg or 1 g) – A carbapenem antibiotic with bactericidal activity.
- Cilastatin (500 mg or 1 g) – Protects Imipenem from breakdown in kidneys.
Excipients: Sodium bicarbonate (for pH adjustment).

Mechanism of Action

Imipenem:
- Binds to penicillin-binding proteins (PBPs), disrupting bacterial cell wall synthesis.
- Covers Gram-positive, Gram-negative, and anaerobic bacteria, including ESBL and AmpC producers.
Cilastatin:
- Blocks renal dehydropeptidase-I, preventing Imipenem degradation and increasing its efficacy.

Spectrum of Activity

✅ Gram-positive: Staphylococcus aureus (MSSA), Streptococcus spp.
✅ Gram-negative: E. coli, Klebsiella, Pseudomonas aeruginosa, Acinetobacter
✅ Anaerobes: Bacteroides fragilis
❌ Not effective against: MRSA, Stenotrophomonas maltophilia, Enterococcus faecium (VRE)

Dosage & Administration

Standard Adult Dose:

Moderate infections: 500 mg IV every 6 hours.
Severe infections: 1 g IV every 6–8 hours.
Max daily dose: 4 g.

Infusion Guidelines:

Reconstitute with 10 mL sterile water (for 500 mg or 1 g vial).
Further dilute in 100 mL NS/D5W.
Infuse over 30–40 minutes.

Dosage Adjustments:

Renal impairment (CrCl <30 mL/min):
- CrCl 15–30: 500 mg every 8–12 hours.
- CrCl <15: 250–500 mg every 12 hours.
Hemodialysis: Administer after dialysis.

Pediatric Dose:

Children ≥3 months: 15–25 mg/kg every 6 hours (max 4 g/day).

Uses (Indications)

Severe intra-abdominal infections
Hospital-acquired pneumonia (HAP/VAP)
Complicated UTIs (pyelonephritis)
Septicemia & endocarditis
Bone/joint infections (osteomyelitis)
Febrile neutropenia (empiric therapy)

Storage & Stability

Unreconstituted powder: Store at 20–25°C, protect from moisture.
Reconstituted solution:
- Stable for 4 hours at room temp or 24 hours if refrigerated (2–8°C).
Do not freeze.

Key Recommendations

✔ Reserve for severe MDR infections (risk of resistance).
✔ Monitor renal function (adjust dose in kidney disease).
✔ Watch for seizures (high risk in renal impairment, CNS disorders).
✔ Avoid in penicillin allergy (cross-reactivity possible).

Important Notes

⚠ Seizure Risk: Higher in renal impairment, CNS disorders, or overdose.
⚠ C. difficile Risk: May cause pseudomembranous colitis (monitor diarrhea).
⚠ Pregnancy (Category C): Use only if benefits outweigh risks.
⚠ Resistance Alert: Overuse leads to CRE (carbapenem-resistant Enterobacteriaceae).

Comparison with Other Carbapenems

Feature	CILAXIN (Imipenem)	Meropenem	Ertapenem
Pseudomonas Coverage	✓	✓	✗
Dosing Frequency	q6h	q8h	q24h
CNS Penetration	Moderate	Excellent	Poor
Seizure Risk	High	Low	Lowest

Conclusion

CILAXIN is a last-line antibiotic for life-threatening MDR infections. Strict antimicrobial stewardship is crucial to prevent resistance.

Reviews

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Be the first to review “CILAXIN”

Description
Reviews (0)

Composition

Active Ingredients:
- Imipenem (500 mg or 1 g) – A carbapenem antibiotic with bactericidal activity.
- Cilastatin (500 mg or 1 g) – Protects Imipenem from breakdown in kidneys.
Excipients: Sodium bicarbonate (for pH adjustment).

Mechanism of Action

Imipenem:
- Binds to penicillin-binding proteins (PBPs), disrupting bacterial cell wall synthesis.
- Covers Gram-positive, Gram-negative, and anaerobic bacteria, including ESBL and AmpC producers.
Cilastatin:
- Blocks renal dehydropeptidase-I, preventing Imipenem degradation and increasing its efficacy.

Spectrum of Activity

✅ Gram-positive: Staphylococcus aureus (MSSA), Streptococcus spp.
✅ Gram-negative: E. coli, Klebsiella, Pseudomonas aeruginosa, Acinetobacter
✅ Anaerobes: Bacteroides fragilis
❌ Not effective against: MRSA, Stenotrophomonas maltophilia, Enterococcus faecium (VRE)

Dosage & Administration

Standard Adult Dose:

Moderate infections: 500 mg IV every 6 hours.
Severe infections: 1 g IV every 6–8 hours.
Max daily dose: 4 g.

Infusion Guidelines:

Reconstitute with 10 mL sterile water (for 500 mg or 1 g vial).
Further dilute in 100 mL NS/D5W.
Infuse over 30–40 minutes.

Dosage Adjustments:

Renal impairment (CrCl <30 mL/min):
- CrCl 15–30: 500 mg every 8–12 hours.
- CrCl <15: 250–500 mg every 12 hours.
Hemodialysis: Administer after dialysis.

Pediatric Dose:

Children ≥3 months: 15–25 mg/kg every 6 hours (max 4 g/day).

Uses (Indications)

Severe intra-abdominal infections
Hospital-acquired pneumonia (HAP/VAP)
Complicated UTIs (pyelonephritis)
Septicemia & endocarditis
Bone/joint infections (osteomyelitis)
Febrile neutropenia (empiric therapy)

Storage & Stability

Unreconstituted powder: Store at 20–25°C, protect from moisture.
Reconstituted solution:
- Stable for 4 hours at room temp or 24 hours if refrigerated (2–8°C).
Do not freeze.

Key Recommendations

✔ Reserve for severe MDR infections (risk of resistance).
✔ Monitor renal function (adjust dose in kidney disease).
✔ Watch for seizures (high risk in renal impairment, CNS disorders).
✔ Avoid in penicillin allergy (cross-reactivity possible).

Important Notes

⚠ Seizure Risk: Higher in renal impairment, CNS disorders, or overdose.
⚠ C. difficile Risk: May cause pseudomembranous colitis (monitor diarrhea).
⚠ Pregnancy (Category C): Use only if benefits outweigh risks.
⚠ Resistance Alert: Overuse leads to CRE (carbapenem-resistant Enterobacteriaceae).

Comparison with Other Carbapenems

Feature	CILAXIN (Imipenem)	Meropenem	Ertapenem
Pseudomonas Coverage	✓	✓	✗
Dosing Frequency	q6h	q8h	q24h
CNS Penetration	Moderate	Excellent	Poor
Seizure Risk	High	Low	Lowest

Conclusion

CILAXIN is a last-line antibiotic for life-threatening MDR infections. Strict antimicrobial stewardship is crucial to prevent resistance.

Reviews

There are no reviews yet.

Be the first to review “CILAXIN”

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