GERTA 1 GM

Antibacterial

Description
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GERTA 1GM is a broad-spectrum carbapenem antibiotic combining Imipenem (1g) and Cilastatin (1g). It is used for severe, multi-drug resistant (MDR) bacterial infections, particularly in hospital settings.

Composition

Active Ingredients:
- Imipenem (1g) – A carbapenem antibiotic.
- Cilastatin (1g) – A renal dehydropeptidase inhibitor (prevents Imipenem breakdown in kidneys).
Excipients: Sodium bicarbonate (for pH adjustment).

Mechanism of Action

Imipenem:
- Binds to penicillin-binding proteins (PBPs), disrupting bacterial cell wall synthesis.
- Bactericidal against a wide range of Gram-positive & Gram-negative bacteria, including ESBL & AmpC producers.
Cilastatin:
- Blocks renal metabolism of Imipenem, increasing its effectiveness.

Spectrum of Activity

✅ Gram-positive: MRSA (some strains), Streptococcus, Enterococcus (not VRE) ✅ Gram-negative: E. coli, Klebsiella, Pseudomonas aeruginosa, Acinetobacter ✅ Anaerobes: Bacteroides fragilis ❌ Not effective against: MRSA (most strains), Stenotrophomonas maltophilia

Dosage & Administration

Standard Adult Dose:

1g Imipenem + 1g Cilastatin IV every 6–8 hours (infused over 30–60 mins).
Max dose: 4g/day (severe infections).

Adjustments:

Renal impairment (CrCl <30 mL/min):
- CrCl 15–30: 500 mg every 6–8 hrs.
- CrCl <15: 250 mg every 6–12 hrs.
Hemodialysis: Administer after dialysis.

Pediatric Dose:

Children ≥3 months: 15–25 mg/kg every 6 hrs (max 4g/day).

Uses (Indications)

Severe intra-abdominal infections
Complicated UTIs (pyelonephritis)
Hospital-acquired pneumonia (HAP/VAP)
Septicemia & endocarditis
Bone/joint infections (osteomyelitis)
Febrile neutropenia (empiric therapy)

Storage & Stability

Unreconstituted powder: Store at 20–25°C, protect from moisture.
Reconstituted solution:
- Stable for 4 hrs at room temp or 24 hrs if refrigerated (2–8°C).
Do not freeze.

Key Recommendations

✔ Use for severe infections only (risk of resistance development). ✔ Monitor renal function (adjust dose in kidney disease). ✔ Check for seizures (high doses in renal failure increase risk). ✔ Avoid in penicillin allergy (cross-reactivity possible).

Important Notes

⚠ Seizure Risk: Higher in renal impairment, CNS disorders, or overdose. ⚠ C. difficile Risk: May cause pseudomembranous colitis (monitor diarrhea). ⚠ Pregnancy (Category C): Use only if benefits outweigh risks. ⚠ Resistance Alert: Overuse leads to carbapenem-resistant Enterobacteriaceae (CRE).

Comparison with Other Carbapenems

Feature	GERTA (Imipenem)	Meropenem	Ertapenem
Pseudomonas Coverage	✓	✓	✗
Dosing Frequency	q6-8h	q8h	q24h
CNS Penetration	Good	Excellent	Poor
Seizure Risk	Higher	Lower	Lowest

Conclusion

GERTA 1GM is a powerful carbapenem reserved for life-threatening MDR infections. Strict antibiotic stewardship is crucial to prevent resistance.

Composition

Active Ingredients:
- Imipenem (1g) – A carbapenem antibiotic.
- Cilastatin (1g) – A renal dehydropeptidase inhibitor (prevents Imipenem breakdown in kidneys).
Excipients: Sodium bicarbonate (for pH adjustment).

Mechanism of Action

Imipenem:
- Binds to penicillin-binding proteins (PBPs), disrupting bacterial cell wall synthesis.
- Bactericidal against a wide range of Gram-positive & Gram-negative bacteria, including ESBL & AmpC producers.
Cilastatin:
- Blocks renal metabolism of Imipenem, increasing its effectiveness.

Spectrum of Activity

✅ Gram-positive: MRSA (some strains), Streptococcus, Enterococcus (not VRE)
✅ Gram-negative: E. coli, Klebsiella, Pseudomonas aeruginosa, Acinetobacter
✅ Anaerobes: Bacteroides fragilis
❌ Not effective against: MRSA (most strains), Stenotrophomonas maltophilia

Dosage & Administration

Standard Adult Dose:

1g Imipenem + 1g Cilastatin IV every 6–8 hours (infused over 30–60 mins).
Max dose: 4g/day (severe infections).

Adjustments:

Renal impairment (CrCl <30 mL/min):
- CrCl 15–30: 500 mg every 6–8 hrs.
- CrCl <15: 250 mg every 6–12 hrs.
Hemodialysis: Administer after dialysis.

Pediatric Dose:

Children ≥3 months: 15–25 mg/kg every 6 hrs (max 4g/day).

Uses (Indications)

Severe intra-abdominal infections
Complicated UTIs (pyelonephritis)
Hospital-acquired pneumonia (HAP/VAP)
Septicemia & endocarditis
Bone/joint infections (osteomyelitis)
Febrile neutropenia (empiric therapy)

Storage & Stability

Unreconstituted powder: Store at 20–25°C, protect from moisture.
Reconstituted solution:
- Stable for 4 hrs at room temp or 24 hrs if refrigerated (2–8°C).
Do not freeze.

Key Recommendations

✔ Use for severe infections only (risk of resistance development).
✔ Monitor renal function (adjust dose in kidney disease).
✔ Check for seizures (high doses in renal failure increase risk).
✔ Avoid in penicillin allergy (cross-reactivity possible).

Important Notes

⚠ Seizure Risk: Higher in renal impairment, CNS disorders, or overdose.
⚠ C. difficile Risk: May cause pseudomembranous colitis (monitor diarrhea).
⚠ Pregnancy (Category C): Use only if benefits outweigh risks.
⚠ Resistance Alert: Overuse leads to carbapenem-resistant Enterobacteriaceae (CRE).

Comparison with Other Carbapenems

Feature	GERTA (Imipenem)	Meropenem	Ertapenem
Pseudomonas Coverage	✓	✓	✗
Dosing Frequency	q6-8h	q8h	q24h
CNS Penetration	Good	Excellent	Poor
Seizure Risk	Higher	Lower	Lowest

Conclusion

GERTA 1GM is a powerful carbapenem reserved for life-threatening MDR infections. Strict antibiotic stewardship is crucial to prevent resistance.

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Composition

Active Ingredients:
- Imipenem (1g) – A carbapenem antibiotic.
- Cilastatin (1g) – A renal dehydropeptidase inhibitor (prevents Imipenem breakdown in kidneys).
Excipients: Sodium bicarbonate (for pH adjustment).

Mechanism of Action

Imipenem:
- Binds to penicillin-binding proteins (PBPs), disrupting bacterial cell wall synthesis.
- Bactericidal against a wide range of Gram-positive & Gram-negative bacteria, including ESBL & AmpC producers.
Cilastatin:
- Blocks renal metabolism of Imipenem, increasing its effectiveness.

Spectrum of Activity

✅ Gram-positive: MRSA (some strains), Streptococcus, Enterococcus (not VRE)
✅ Gram-negative: E. coli, Klebsiella, Pseudomonas aeruginosa, Acinetobacter
✅ Anaerobes: Bacteroides fragilis
❌ Not effective against: MRSA (most strains), Stenotrophomonas maltophilia

Dosage & Administration

Standard Adult Dose:

1g Imipenem + 1g Cilastatin IV every 6–8 hours (infused over 30–60 mins).
Max dose: 4g/day (severe infections).

Adjustments:

Renal impairment (CrCl <30 mL/min):
- CrCl 15–30: 500 mg every 6–8 hrs.
- CrCl <15: 250 mg every 6–12 hrs.
Hemodialysis: Administer after dialysis.

Pediatric Dose:

Children ≥3 months: 15–25 mg/kg every 6 hrs (max 4g/day).

Uses (Indications)

Severe intra-abdominal infections
Complicated UTIs (pyelonephritis)
Hospital-acquired pneumonia (HAP/VAP)
Septicemia & endocarditis
Bone/joint infections (osteomyelitis)
Febrile neutropenia (empiric therapy)

Storage & Stability

Unreconstituted powder: Store at 20–25°C, protect from moisture.
Reconstituted solution:
- Stable for 4 hrs at room temp or 24 hrs if refrigerated (2–8°C).
Do not freeze.

Key Recommendations

✔ Use for severe infections only (risk of resistance development).
✔ Monitor renal function (adjust dose in kidney disease).
✔ Check for seizures (high doses in renal failure increase risk).
✔ Avoid in penicillin allergy (cross-reactivity possible).

Important Notes

⚠ Seizure Risk: Higher in renal impairment, CNS disorders, or overdose.
⚠ C. difficile Risk: May cause pseudomembranous colitis (monitor diarrhea).
⚠ Pregnancy (Category C): Use only if benefits outweigh risks.
⚠ Resistance Alert: Overuse leads to carbapenem-resistant Enterobacteriaceae (CRE).

Comparison with Other Carbapenems

Feature	GERTA (Imipenem)	Meropenem	Ertapenem
Pseudomonas Coverage	✓	✓	✗
Dosing Frequency	q6-8h	q8h	q24h
CNS Penetration	Good	Excellent	Poor
Seizure Risk	Higher	Lower	Lowest

Conclusion

GERTA 1GM is a powerful carbapenem reserved for life-threatening MDR infections. Strict antibiotic stewardship is crucial to prevent resistance.

Reviews

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Be the first to review “GERTA 1 GM”

Description
Reviews (0)

Composition

Active Ingredients:
- Imipenem (1g) – A carbapenem antibiotic.
- Cilastatin (1g) – A renal dehydropeptidase inhibitor (prevents Imipenem breakdown in kidneys).
Excipients: Sodium bicarbonate (for pH adjustment).

Mechanism of Action

Imipenem:
- Binds to penicillin-binding proteins (PBPs), disrupting bacterial cell wall synthesis.
- Bactericidal against a wide range of Gram-positive & Gram-negative bacteria, including ESBL & AmpC producers.
Cilastatin:
- Blocks renal metabolism of Imipenem, increasing its effectiveness.

Spectrum of Activity

✅ Gram-positive: MRSA (some strains), Streptococcus, Enterococcus (not VRE)
✅ Gram-negative: E. coli, Klebsiella, Pseudomonas aeruginosa, Acinetobacter
✅ Anaerobes: Bacteroides fragilis
❌ Not effective against: MRSA (most strains), Stenotrophomonas maltophilia

Dosage & Administration

Standard Adult Dose:

1g Imipenem + 1g Cilastatin IV every 6–8 hours (infused over 30–60 mins).
Max dose: 4g/day (severe infections).

Adjustments:

Renal impairment (CrCl <30 mL/min):
- CrCl 15–30: 500 mg every 6–8 hrs.
- CrCl <15: 250 mg every 6–12 hrs.
Hemodialysis: Administer after dialysis.

Pediatric Dose:

Children ≥3 months: 15–25 mg/kg every 6 hrs (max 4g/day).

Uses (Indications)

Severe intra-abdominal infections
Complicated UTIs (pyelonephritis)
Hospital-acquired pneumonia (HAP/VAP)
Septicemia & endocarditis
Bone/joint infections (osteomyelitis)
Febrile neutropenia (empiric therapy)

Storage & Stability

Unreconstituted powder: Store at 20–25°C, protect from moisture.
Reconstituted solution:
- Stable for 4 hrs at room temp or 24 hrs if refrigerated (2–8°C).
Do not freeze.

Key Recommendations

✔ Use for severe infections only (risk of resistance development).
✔ Monitor renal function (adjust dose in kidney disease).
✔ Check for seizures (high doses in renal failure increase risk).
✔ Avoid in penicillin allergy (cross-reactivity possible).

Important Notes

⚠ Seizure Risk: Higher in renal impairment, CNS disorders, or overdose.
⚠ C. difficile Risk: May cause pseudomembranous colitis (monitor diarrhea).
⚠ Pregnancy (Category C): Use only if benefits outweigh risks.
⚠ Resistance Alert: Overuse leads to carbapenem-resistant Enterobacteriaceae (CRE).

Comparison with Other Carbapenems

Feature	GERTA (Imipenem)	Meropenem	Ertapenem
Pseudomonas Coverage	✓	✓	✗
Dosing Frequency	q6-8h	q8h	q24h
CNS Penetration	Good	Excellent	Poor
Seizure Risk	Higher	Lower	Lowest

Conclusion

GERTA 1GM is a powerful carbapenem reserved for life-threatening MDR infections. Strict antibiotic stewardship is crucial to prevent resistance.

Reviews

There are no reviews yet.

Be the first to review “GERTA 1 GM”

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