Meroza I.V 500mg

Antibacterial

Description
Shipping Options
Customer Reviews

MEROZA IV 500 MG is a sterile, lyophilized powder for intravenous (IV) infusion, containing Meropenem, a broad-spectrum carbapenem antibiotic. It is used for the treatment of severe bacterial infections, including multi-drug resistant (MDR) infections.

Composition

Active Ingredient:
- Meropenem Trihydrate (equivalent to 500 mg Meropenem per vial)
Excipients:
- Sodium carbonate (for pH adjustment)
- Sterile Water for Injection (after reconstitution)

Mechanism of Action

Bactericidal action by inhibiting bacterial cell wall synthesis (binds to penicillin-binding proteins [PBPs]).
Broad-spectrum activity against:
- Gram-negative bacteria (E. coli, Klebsiella, Pseudomonas)
- Gram-positive bacteria (Streptococcus pneumoniae)
- Anaerobic bacteria (Bacteroides fragilis)
Resistant to most beta-lactamases, but not metallo-beta-lactamases (MBLs).

Dosage & Administration

Standard Adult Dose:

500 mg IV every 8 hours (for mild-moderate infections).
1 g IV every 8 hours (for severe infections like meningitis, hospital-acquired pneumonia).
Infusion Time: Over 15–30 minutes (or extended infusion in critical cases).

Pediatric Dose:

20 mg/kg every 8 hours (max 2 g/day for severe infections).

Renal Dose Adjustment:

CrCl 25–50 mL/min: 500 mg–1 g every 12 hours.
CrCl <25 mL/min: 250–500 mg every 24 hours.

Uses (Indications)

✔ Complicated intra-abdominal infections (with metronidazole for anaerobes) ✔ Bacterial meningitis (in pediatric & adult patients) ✔ Hospital-acquired pneumonia (HAP) & ventilator-associated pneumonia (VAP) ✔ Complicated skin & soft tissue infections ✔ Septicemia (bloodstream infections) ✔ Febrile neutropenia (empiric therapy)

Storage

Unreconstituted powder: Store below 25°C, protect from moisture.
Reconstituted solution:
- Stable for 1 hour at RT (25°C) or 24 hours if refrigerated (2–8°C).
- Do not freeze.

Recommendations

✔ Administer as IV infusion (15–30 min); extended infusion (3 hours) for critical infections. ✔ Monitor renal function, liver enzymes, and CBC during therapy. ✔ Not effective against MRSA (add vancomycin/linezolid if MRSA suspected).

Important Note

Contraindications:

Hypersensitivity to meropenem or other carbapenems (e.g., imipenem).
History of severe anaphylaxis to beta-lactams.

Side Effects:

Common: Diarrhea, nausea, headache, rash.
Serious: Seizures (in high doses), C. difficile colitis, thrombocytopenia.

Drug Interactions:

Valproic acid: ↓ Levels (increased seizure risk).
Probenecid: ↑ Meropenem levels (avoid concurrent use).

Pregnancy & Lactation:

Category B (use only if benefits outweigh risks).
Breastfeeding: Caution (small amounts excreted in milk).

Presentation

Single-dose vial (500 mg powder for reconstitution).

Composition

Active Ingredient:
- Meropenem Trihydrate (equivalent to 500 mg Meropenem per vial)
Excipients:
- Sodium carbonate (for pH adjustment)
- Sterile Water for Injection (after reconstitution)

Mechanism of Action

Bactericidal action by inhibiting bacterial cell wall synthesis (binds to penicillin-binding proteins [PBPs]).
Broad-spectrum activity against:
- Gram-negative bacteria (E. coli, Klebsiella, Pseudomonas)
- Gram-positive bacteria (Streptococcus pneumoniae)
- Anaerobic bacteria (Bacteroides fragilis)
Resistant to most beta-lactamases, but not metallo-beta-lactamases (MBLs).

Dosage & Administration

Standard Adult Dose:

500 mg IV every 8 hours (for mild-moderate infections).
1 g IV every 8 hours (for severe infections like meningitis, hospital-acquired pneumonia).
Infusion Time: Over 15–30 minutes (or extended infusion in critical cases).

Pediatric Dose:

20 mg/kg every 8 hours (max 2 g/day for severe infections).

Renal Dose Adjustment:

CrCl 25–50 mL/min: 500 mg–1 g every 12 hours.
CrCl <25 mL/min: 250–500 mg every 24 hours.

Uses (Indications)

✔ Complicated intra-abdominal infections (with metronidazole for anaerobes)
✔ Bacterial meningitis (in pediatric & adult patients)
✔ Hospital-acquired pneumonia (HAP) & ventilator-associated pneumonia (VAP)
✔ Complicated skin & soft tissue infections
✔ Septicemia (bloodstream infections)
✔ Febrile neutropenia (empiric therapy)

Storage

Unreconstituted powder: Store below 25°C, protect from moisture.
Reconstituted solution:
- Stable for 1 hour at RT (25°C) or 24 hours if refrigerated (2–8°C).
- Do not freeze.

Recommendations

✔ Administer as IV infusion (15–30 min); extended infusion (3 hours) for critical infections.
✔ Monitor renal function, liver enzymes, and CBC during therapy.
✔ Not effective against MRSA (add vancomycin/linezolid if MRSA suspected).

Important Note

Contraindications:

Hypersensitivity to meropenem or other carbapenems (e.g., imipenem).
History of severe anaphylaxis to beta-lactams.

Side Effects:

Common: Diarrhea, nausea, headache, rash.
Serious: Seizures (in high doses), C. difficile colitis, thrombocytopenia.

Drug Interactions:

Valproic acid: ↓ Levels (increased seizure risk).
Probenecid: ↑ Meropenem levels (avoid concurrent use).

Pregnancy & Lactation:

Category B (use only if benefits outweigh risks).
Breastfeeding: Caution (small amounts excreted in milk).

Presentation

Single-dose vial (500 mg powder for reconstitution).

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Composition

Active Ingredient:
- Meropenem Trihydrate (equivalent to 500 mg Meropenem per vial)
Excipients:
- Sodium carbonate (for pH adjustment)
- Sterile Water for Injection (after reconstitution)

Mechanism of Action

Bactericidal action by inhibiting bacterial cell wall synthesis (binds to penicillin-binding proteins [PBPs]).
Broad-spectrum activity against:
- Gram-negative bacteria (E. coli, Klebsiella, Pseudomonas)
- Gram-positive bacteria (Streptococcus pneumoniae)
- Anaerobic bacteria (Bacteroides fragilis)
Resistant to most beta-lactamases, but not metallo-beta-lactamases (MBLs).

Dosage & Administration

Standard Adult Dose:

500 mg IV every 8 hours (for mild-moderate infections).
1 g IV every 8 hours (for severe infections like meningitis, hospital-acquired pneumonia).
Infusion Time: Over 15–30 minutes (or extended infusion in critical cases).

Pediatric Dose:

20 mg/kg every 8 hours (max 2 g/day for severe infections).

Renal Dose Adjustment:

CrCl 25–50 mL/min: 500 mg–1 g every 12 hours.
CrCl <25 mL/min: 250–500 mg every 24 hours.

Uses (Indications)

✔ Complicated intra-abdominal infections (with metronidazole for anaerobes)
✔ Bacterial meningitis (in pediatric & adult patients)
✔ Hospital-acquired pneumonia (HAP) & ventilator-associated pneumonia (VAP)
✔ Complicated skin & soft tissue infections
✔ Septicemia (bloodstream infections)
✔ Febrile neutropenia (empiric therapy)

Storage

Unreconstituted powder: Store below 25°C, protect from moisture.
Reconstituted solution:
- Stable for 1 hour at RT (25°C) or 24 hours if refrigerated (2–8°C).
- Do not freeze.

Recommendations

✔ Administer as IV infusion (15–30 min); extended infusion (3 hours) for critical infections.
✔ Monitor renal function, liver enzymes, and CBC during therapy.
✔ Not effective against MRSA (add vancomycin/linezolid if MRSA suspected).

Important Note

Contraindications:

Hypersensitivity to meropenem or other carbapenems (e.g., imipenem).
History of severe anaphylaxis to beta-lactams.

Side Effects:

Common: Diarrhea, nausea, headache, rash.
Serious: Seizures (in high doses), C. difficile colitis, thrombocytopenia.

Drug Interactions:

Valproic acid: ↓ Levels (increased seizure risk).
Probenecid: ↑ Meropenem levels (avoid concurrent use).

Pregnancy & Lactation:

Category B (use only if benefits outweigh risks).
Breastfeeding: Caution (small amounts excreted in milk).

Presentation

Single-dose vial (500 mg powder for reconstitution).

Reviews

There are no reviews yet.

Be the first to review “Meroza I.V 500mg”

Description
Reviews (0)

Composition

Active Ingredient:
- Meropenem Trihydrate (equivalent to 500 mg Meropenem per vial)
Excipients:
- Sodium carbonate (for pH adjustment)
- Sterile Water for Injection (after reconstitution)

Mechanism of Action

Bactericidal action by inhibiting bacterial cell wall synthesis (binds to penicillin-binding proteins [PBPs]).
Broad-spectrum activity against:
- Gram-negative bacteria (E. coli, Klebsiella, Pseudomonas)
- Gram-positive bacteria (Streptococcus pneumoniae)
- Anaerobic bacteria (Bacteroides fragilis)
Resistant to most beta-lactamases, but not metallo-beta-lactamases (MBLs).

Dosage & Administration

Standard Adult Dose:

500 mg IV every 8 hours (for mild-moderate infections).
1 g IV every 8 hours (for severe infections like meningitis, hospital-acquired pneumonia).
Infusion Time: Over 15–30 minutes (or extended infusion in critical cases).

Pediatric Dose:

20 mg/kg every 8 hours (max 2 g/day for severe infections).

Renal Dose Adjustment:

CrCl 25–50 mL/min: 500 mg–1 g every 12 hours.
CrCl <25 mL/min: 250–500 mg every 24 hours.

Uses (Indications)

✔ Complicated intra-abdominal infections (with metronidazole for anaerobes)
✔ Bacterial meningitis (in pediatric & adult patients)
✔ Hospital-acquired pneumonia (HAP) & ventilator-associated pneumonia (VAP)
✔ Complicated skin & soft tissue infections
✔ Septicemia (bloodstream infections)
✔ Febrile neutropenia (empiric therapy)

Storage

Unreconstituted powder: Store below 25°C, protect from moisture.
Reconstituted solution:
- Stable for 1 hour at RT (25°C) or 24 hours if refrigerated (2–8°C).
- Do not freeze.

Recommendations

✔ Administer as IV infusion (15–30 min); extended infusion (3 hours) for critical infections.
✔ Monitor renal function, liver enzymes, and CBC during therapy.
✔ Not effective against MRSA (add vancomycin/linezolid if MRSA suspected).

Important Note

Contraindications:

Hypersensitivity to meropenem or other carbapenems (e.g., imipenem).
History of severe anaphylaxis to beta-lactams.

Side Effects:

Common: Diarrhea, nausea, headache, rash.
Serious: Seizures (in high doses), C. difficile colitis, thrombocytopenia.

Drug Interactions:

Valproic acid: ↓ Levels (increased seizure risk).
Probenecid: ↑ Meropenem levels (avoid concurrent use).

Pregnancy & Lactation:

Category B (use only if benefits outweigh risks).
Breastfeeding: Caution (small amounts excreted in milk).

Presentation

Single-dose vial (500 mg powder for reconstitution).

Reviews

There are no reviews yet.

Be the first to review “Meroza I.V 500mg”

Medical Disclaimer

Anteka Pharmacy primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on Anteka Pharmacy. Our mission is to support, not replace, the doctor-patient relationship.