TAZACT 4.5 MG

Antibacterial

Description
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TAZACT 4.5 GM is a sterile, lyophilized powder for intravenous (IV) infusion, combining Piperacillin Sodium (a broad-spectrum penicillin antibiotic) and Tazobactam Sodium (a beta-lactamase inhibitor). It is used for moderate to severe infections caused by beta-lactamase-producing bacteria.

Composition

Active Ingredients per vial:
- Piperacillin Sodium (equivalent to 4 g Piperacillin).
- Tazobactam Sodium (equivalent to 0.5 g Tazobactam).
Excipients: Sodium citrate, sodium bicarbonate (for pH adjustment).

Mechanism of Action

Piperacillin:
- Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
- Broad-spectrum coverage against Gram-positive, Gram-negative, and anaerobic bacteria.
Tazobactam:
- Irreversibly inhibits beta-lactamase enzymes, protecting Piperacillin from degradation.
- Extends activity against ESBL-producing Enterobacteriaceae and some resistant strains.

Dosage & Administration

Standard Adult Dose:

4.5 g (4g + 0.5g) IV every 6–8 hours (infused over 30 minutes).
Severe Infections (e.g., nosocomial pneumonia): Up to 4.5 g every 6 hours.

Pediatric Dose (≥2 months):

90–112.5 mg/kg every 6–8 hours (max 4.5 g per dose).

Renal Dose Adjustment:

CrCl 20–40 mL/min: 3.375 g every 6 hours.
CrCl <20 mL/min: 2.25 g every 6–8 hours.
Hemodialysis: Administer after dialysis.

Administration:

Reconstitute with 20 mL sterile water/NS, then dilute in 50–100 mL compatible IV fluid.
Infuse over 30 minutes (prolonged infusion may be used for critical infections).

Uses (Indications)

✔ Intra-abdominal infections (with metronidazole for anaerobes). ✔ Nosocomial pneumonia (HAP/VAP). ✔ Complicated skin & soft tissue infections. ✔ Complicated urinary tract infections (cUTIs). ✔ Septicemia (bloodstream infections).

Storage

Unreconstituted powder: Store below 25°C; protect from moisture.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze.

Recommendations

✔ Monitor renal function, liver enzymes, and CBC during prolonged therapy. ✔ Not effective against MRSA (add vancomycin/linezolid if suspected). ✔ Avoid prolonged use to prevent superinfections (e.g., C. difficile).

Important Note

Contraindications:

Hypersensitivity to penicillins, cephalosporins, or beta-lactamase inhibitors.
History of severe anaphylactic reactions to beta-lactams.

Side Effects:

Common: Diarrhea, headache, nausea, rash.
Serious:
- C. difficile-associated diarrhea.
- Hematologic effects (leukopenia, thrombocytopenia).
- Hypokalemia (with high doses).

Drug Interactions:

Probenecid: ↑ Piperacillin levels (avoid concurrent use).
Anticoagulants: May ↑ bleeding risk (monitor INR).
Vecuronium: ↑ Neuromuscular blockade.

Pregnancy & Lactation:

Category B (use only if clearly needed).
Breastfeeding: Low excretion in milk (caution advised).

Presentation

Single-dose vial (4.5 g powder for reconstitution).

Composition

Active Ingredients per vial:
- Piperacillin Sodium (equivalent to 4 g Piperacillin).
- Tazobactam Sodium (equivalent to 0.5 g Tazobactam).
Excipients: Sodium citrate, sodium bicarbonate (for pH adjustment).

Mechanism of Action

Piperacillin:
- Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
- Broad-spectrum coverage against Gram-positive, Gram-negative, and anaerobic bacteria.
Tazobactam:
- Irreversibly inhibits beta-lactamase enzymes, protecting Piperacillin from degradation.
- Extends activity against ESBL-producing Enterobacteriaceae and some resistant strains.

Dosage & Administration

Standard Adult Dose:

4.5 g (4g + 0.5g) IV every 6–8 hours (infused over 30 minutes).
Severe Infections (e.g., nosocomial pneumonia): Up to 4.5 g every 6 hours.

Pediatric Dose (≥2 months):

90–112.5 mg/kg every 6–8 hours (max 4.5 g per dose).

Renal Dose Adjustment:

CrCl 20–40 mL/min: 3.375 g every 6 hours.
CrCl <20 mL/min: 2.25 g every 6–8 hours.
Hemodialysis: Administer after dialysis.

Administration:

Reconstitute with 20 mL sterile water/NS, then dilute in 50–100 mL compatible IV fluid.
Infuse over 30 minutes (prolonged infusion may be used for critical infections).

Uses (Indications)

✔ Intra-abdominal infections (with metronidazole for anaerobes).
✔ Nosocomial pneumonia (HAP/VAP).
✔ Complicated skin & soft tissue infections.
✔ Complicated urinary tract infections (cUTIs).
✔ Septicemia (bloodstream infections).

Storage

Unreconstituted powder: Store below 25°C; protect from moisture.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze.

Recommendations

✔ Monitor renal function, liver enzymes, and CBC during prolonged therapy.
✔ Not effective against MRSA (add vancomycin/linezolid if suspected).
✔ Avoid prolonged use to prevent superinfections (e.g., C. difficile).

Important Note

Contraindications:

Hypersensitivity to penicillins, cephalosporins, or beta-lactamase inhibitors.
History of severe anaphylactic reactions to beta-lactams.

Side Effects:

Common: Diarrhea, headache, nausea, rash.
Serious:
- C. difficile-associated diarrhea.
- Hematologic effects (leukopenia, thrombocytopenia).
- Hypokalemia (with high doses).

Drug Interactions:

Probenecid: ↑ Piperacillin levels (avoid concurrent use).
Anticoagulants: May ↑ bleeding risk (monitor INR).
Vecuronium: ↑ Neuromuscular blockade.

Pregnancy & Lactation:

Category B (use only if clearly needed).
Breastfeeding: Low excretion in milk (caution advised).

Presentation

Single-dose vial (4.5 g powder for reconstitution).

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Composition

Active Ingredients per vial:
- Piperacillin Sodium (equivalent to 4 g Piperacillin).
- Tazobactam Sodium (equivalent to 0.5 g Tazobactam).
Excipients: Sodium citrate, sodium bicarbonate (for pH adjustment).

Mechanism of Action

Piperacillin:
- Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
- Broad-spectrum coverage against Gram-positive, Gram-negative, and anaerobic bacteria.
Tazobactam:
- Irreversibly inhibits beta-lactamase enzymes, protecting Piperacillin from degradation.
- Extends activity against ESBL-producing Enterobacteriaceae and some resistant strains.

Dosage & Administration

Standard Adult Dose:

4.5 g (4g + 0.5g) IV every 6–8 hours (infused over 30 minutes).
Severe Infections (e.g., nosocomial pneumonia): Up to 4.5 g every 6 hours.

Pediatric Dose (≥2 months):

90–112.5 mg/kg every 6–8 hours (max 4.5 g per dose).

Renal Dose Adjustment:

CrCl 20–40 mL/min: 3.375 g every 6 hours.
CrCl <20 mL/min: 2.25 g every 6–8 hours.
Hemodialysis: Administer after dialysis.

Administration:

Reconstitute with 20 mL sterile water/NS, then dilute in 50–100 mL compatible IV fluid.
Infuse over 30 minutes (prolonged infusion may be used for critical infections).

Uses (Indications)

✔ Intra-abdominal infections (with metronidazole for anaerobes).
✔ Nosocomial pneumonia (HAP/VAP).
✔ Complicated skin & soft tissue infections.
✔ Complicated urinary tract infections (cUTIs).
✔ Septicemia (bloodstream infections).

Storage

Unreconstituted powder: Store below 25°C; protect from moisture.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze.

Recommendations

✔ Monitor renal function, liver enzymes, and CBC during prolonged therapy.
✔ Not effective against MRSA (add vancomycin/linezolid if suspected).
✔ Avoid prolonged use to prevent superinfections (e.g., C. difficile).

Important Note

Contraindications:

Hypersensitivity to penicillins, cephalosporins, or beta-lactamase inhibitors.
History of severe anaphylactic reactions to beta-lactams.

Side Effects:

Common: Diarrhea, headache, nausea, rash.
Serious:
- C. difficile-associated diarrhea.
- Hematologic effects (leukopenia, thrombocytopenia).
- Hypokalemia (with high doses).

Drug Interactions:

Probenecid: ↑ Piperacillin levels (avoid concurrent use).
Anticoagulants: May ↑ bleeding risk (monitor INR).
Vecuronium: ↑ Neuromuscular blockade.

Pregnancy & Lactation:

Category B (use only if clearly needed).
Breastfeeding: Low excretion in milk (caution advised).

Presentation

Single-dose vial (4.5 g powder for reconstitution).

Reviews

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Be the first to review “TAZACT 4.5 MG”

Description
Reviews (0)

Composition

Active Ingredients per vial:
- Piperacillin Sodium (equivalent to 4 g Piperacillin).
- Tazobactam Sodium (equivalent to 0.5 g Tazobactam).
Excipients: Sodium citrate, sodium bicarbonate (for pH adjustment).

Mechanism of Action

Piperacillin:
- Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
- Broad-spectrum coverage against Gram-positive, Gram-negative, and anaerobic bacteria.
Tazobactam:
- Irreversibly inhibits beta-lactamase enzymes, protecting Piperacillin from degradation.
- Extends activity against ESBL-producing Enterobacteriaceae and some resistant strains.

Dosage & Administration

Standard Adult Dose:

4.5 g (4g + 0.5g) IV every 6–8 hours (infused over 30 minutes).
Severe Infections (e.g., nosocomial pneumonia): Up to 4.5 g every 6 hours.

Pediatric Dose (≥2 months):

90–112.5 mg/kg every 6–8 hours (max 4.5 g per dose).

Renal Dose Adjustment:

CrCl 20–40 mL/min: 3.375 g every 6 hours.
CrCl <20 mL/min: 2.25 g every 6–8 hours.
Hemodialysis: Administer after dialysis.

Administration:

Reconstitute with 20 mL sterile water/NS, then dilute in 50–100 mL compatible IV fluid.
Infuse over 30 minutes (prolonged infusion may be used for critical infections).

Uses (Indications)

✔ Intra-abdominal infections (with metronidazole for anaerobes).
✔ Nosocomial pneumonia (HAP/VAP).
✔ Complicated skin & soft tissue infections.
✔ Complicated urinary tract infections (cUTIs).
✔ Septicemia (bloodstream infections).

Storage

Unreconstituted powder: Store below 25°C; protect from moisture.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze.

Recommendations

✔ Monitor renal function, liver enzymes, and CBC during prolonged therapy.
✔ Not effective against MRSA (add vancomycin/linezolid if suspected).
✔ Avoid prolonged use to prevent superinfections (e.g., C. difficile).

Important Note

Contraindications:

Hypersensitivity to penicillins, cephalosporins, or beta-lactamase inhibitors.
History of severe anaphylactic reactions to beta-lactams.

Side Effects:

Common: Diarrhea, headache, nausea, rash.
Serious:
- C. difficile-associated diarrhea.
- Hematologic effects (leukopenia, thrombocytopenia).
- Hypokalemia (with high doses).

Drug Interactions:

Probenecid: ↑ Piperacillin levels (avoid concurrent use).
Anticoagulants: May ↑ bleeding risk (monitor INR).
Vecuronium: ↑ Neuromuscular blockade.

Pregnancy & Lactation:

Category B (use only if clearly needed).
Breastfeeding: Low excretion in milk (caution advised).

Presentation

Single-dose vial (4.5 g powder for reconstitution).

Reviews

There are no reviews yet.

Be the first to review “TAZACT 4.5 MG”

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