Tiganex Inj

Antibacterial

Description
Shipping Options
Customer Reviews

Tiganex is an intravenous antibiotic containing Tigecycline, a glycylcycline (a derivative of tetracycline). It is a broad-spectrum antibiotic used for complicated infections caused by multidrug-resistant bacteria.

Composition

Active Ingredient: Tigecycline – 50 mg/vial (lyophilized powder).
Excipients: Hydrochloric acid, sodium hydroxide, lactose.

Mechanism of Action

Bacteriostatic (inhibits protein synthesis by binding to the 30S ribosomal subunit).
Broad-spectrum coverage, including:
- Gram-positive (MRSA, VRE*, Streptococcus spp.)
- Gram-negative (E. coli, Klebsiella, Acinetobacter)
- Anaerobes (Bacteroides fragilis)
- Atypical bacteria (Chlamydia, Mycoplasma)
Not effective against Pseudomonas aeruginosa or Proteus spp.

(Limited activity against some Enterococcus faecium strains)*

Dosage & Administration

Standard Adult Dose:

Initial dose: 100 mg IV (single dose).
Maintenance: 50 mg every 12 hours (infused over 30–60 minutes).

Adjustments:

Severe hepatic impairment (Child-Pugh C): Reduce maintenance dose to 25 mg every 12 hours.
No dose adjustment needed for renal impairment.

Pediatrics:

Not recommended for children <18 years (risk of tooth discoloration & bone growth issues).

Uses (Indications)

Complicated skin & soft tissue infections (cSSTI)
Complicated intra-abdominal infections (cIAI)
Community-acquired bacterial pneumonia (CABP)
Bacterial infections resistant to other antibiotics

(Not FDA-approved for diabetic foot infections or bacteremia due to higher mortality risk in some studies.)

Storage

Unreconstituted vials: Store at 20–25°C, protect from light.
Reconstituted solution:
- Stable for 6 hours at room temperature or 24 hours refrigerated (2–8°C).
Do not freeze.

Recommendations

Use only when other antibiotics fail (due to increased mortality risk in some infections).
Monitor for superinfections (e.g., C. difficile, fungal infections).
Avoid in pregnancy & breastfeeding (Category D – fetal harm risk).

Important Notes

⚠ Black Box Warning:

Increased mortality risk observed in some infections (especially hospital-acquired pneumonia).
Reserve for situations where alternatives are inadequate.

Side Effects:

Common: Nausea, vomiting, diarrhea.
Serious: Pancreatitis, hepatic dysfunction, hypersensitivity.

Drug Interactions:

Warfarin (increased INR monitoring needed).
Oral contraceptives (reduced efficacy – use backup contraception).

Conclusion

Tiganex (Tigecycline) is a last-resort antibiotic for MDR infections. Use cautiously due to safety concerns and limited spectrum against some pathogens.

Composition

Active Ingredient: Tigecycline – 50 mg/vial (lyophilized powder).
Excipients: Hydrochloric acid, sodium hydroxide, lactose.

Mechanism of Action

Bacteriostatic (inhibits protein synthesis by binding to the 30S ribosomal subunit).
Broad-spectrum coverage, including:
- Gram-positive (MRSA, VRE*, Streptococcus spp.)
- Gram-negative (E. coli, Klebsiella, Acinetobacter)
- Anaerobes (Bacteroides fragilis)
- Atypical bacteria (Chlamydia, Mycoplasma)
Not effective against Pseudomonas aeruginosa or Proteus spp.

(Limited activity against some Enterococcus faecium strains)*

Dosage & Administration

Standard Adult Dose:

Initial dose: 100 mg IV (single dose).
Maintenance: 50 mg every 12 hours (infused over 30–60 minutes).

Adjustments:

Severe hepatic impairment (Child-Pugh C): Reduce maintenance dose to 25 mg every 12 hours.
No dose adjustment needed for renal impairment.

Pediatrics:

Not recommended for children <18 years (risk of tooth discoloration & bone growth issues).

Uses (Indications)

Complicated skin & soft tissue infections (cSSTI)
Complicated intra-abdominal infections (cIAI)
Community-acquired bacterial pneumonia (CABP)
Bacterial infections resistant to other antibiotics

(Not FDA-approved for diabetic foot infections or bacteremia due to higher mortality risk in some studies.)

Storage

Unreconstituted vials: Store at 20–25°C, protect from light.
Reconstituted solution:
- Stable for 6 hours at room temperature or 24 hours refrigerated (2–8°C).
Do not freeze.

Recommendations

Use only when other antibiotics fail (due to increased mortality risk in some infections).
Monitor for superinfections (e.g., C. difficile, fungal infections).
Avoid in pregnancy & breastfeeding (Category D – fetal harm risk).

Important Notes

⚠ Black Box Warning:

Increased mortality risk observed in some infections (especially hospital-acquired pneumonia).
Reserve for situations where alternatives are inadequate.

Side Effects:

Common: Nausea, vomiting, diarrhea.
Serious: Pancreatitis, hepatic dysfunction, hypersensitivity.

Drug Interactions:

Warfarin (increased INR monitoring needed).
Oral contraceptives (reduced efficacy – use backup contraception).

Conclusion

Tiganex (Tigecycline) is a last-resort antibiotic for MDR infections. Use cautiously due to safety concerns and limited spectrum against some pathogens.

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Composition

Active Ingredient: Tigecycline – 50 mg/vial (lyophilized powder).
Excipients: Hydrochloric acid, sodium hydroxide, lactose.

Mechanism of Action

Bacteriostatic (inhibits protein synthesis by binding to the 30S ribosomal subunit).
Broad-spectrum coverage, including:
- Gram-positive (MRSA, VRE*, Streptococcus spp.)
- Gram-negative (E. coli, Klebsiella, Acinetobacter)
- Anaerobes (Bacteroides fragilis)
- Atypical bacteria (Chlamydia, Mycoplasma)
Not effective against Pseudomonas aeruginosa or Proteus spp.

(Limited activity against some Enterococcus faecium strains)*

Dosage & Administration

Standard Adult Dose:

Initial dose: 100 mg IV (single dose).
Maintenance: 50 mg every 12 hours (infused over 30–60 minutes).

Adjustments:

Severe hepatic impairment (Child-Pugh C): Reduce maintenance dose to 25 mg every 12 hours.
No dose adjustment needed for renal impairment.

Pediatrics:

Not recommended for children <18 years (risk of tooth discoloration & bone growth issues).

Uses (Indications)

Complicated skin & soft tissue infections (cSSTI)
Complicated intra-abdominal infections (cIAI)
Community-acquired bacterial pneumonia (CABP)
Bacterial infections resistant to other antibiotics

(Not FDA-approved for diabetic foot infections or bacteremia due to higher mortality risk in some studies.)

Storage

Unreconstituted vials: Store at 20–25°C, protect from light.
Reconstituted solution:
- Stable for 6 hours at room temperature or 24 hours refrigerated (2–8°C).
Do not freeze.

Recommendations

Use only when other antibiotics fail (due to increased mortality risk in some infections).
Monitor for superinfections (e.g., C. difficile, fungal infections).
Avoid in pregnancy & breastfeeding (Category D – fetal harm risk).

Important Notes

⚠ Black Box Warning:

Increased mortality risk observed in some infections (especially hospital-acquired pneumonia).
Reserve for situations where alternatives are inadequate.

Side Effects:

Common: Nausea, vomiting, diarrhea.
Serious: Pancreatitis, hepatic dysfunction, hypersensitivity.

Drug Interactions:

Warfarin (increased INR monitoring needed).
Oral contraceptives (reduced efficacy – use backup contraception).

Conclusion

Tiganex (Tigecycline) is a last-resort antibiotic for MDR infections. Use cautiously due to safety concerns and limited spectrum against some pathogens.

Reviews

There are no reviews yet.

Be the first to review “Tiganex Inj”

Description
Reviews (0)

Composition

Active Ingredient: Tigecycline – 50 mg/vial (lyophilized powder).
Excipients: Hydrochloric acid, sodium hydroxide, lactose.

Mechanism of Action

Bacteriostatic (inhibits protein synthesis by binding to the 30S ribosomal subunit).
Broad-spectrum coverage, including:
- Gram-positive (MRSA, VRE*, Streptococcus spp.)
- Gram-negative (E. coli, Klebsiella, Acinetobacter)
- Anaerobes (Bacteroides fragilis)
- Atypical bacteria (Chlamydia, Mycoplasma)
Not effective against Pseudomonas aeruginosa or Proteus spp.

(Limited activity against some Enterococcus faecium strains)*

Dosage & Administration

Standard Adult Dose:

Initial dose: 100 mg IV (single dose).
Maintenance: 50 mg every 12 hours (infused over 30–60 minutes).

Adjustments:

Severe hepatic impairment (Child-Pugh C): Reduce maintenance dose to 25 mg every 12 hours.
No dose adjustment needed for renal impairment.

Pediatrics:

Not recommended for children <18 years (risk of tooth discoloration & bone growth issues).

Uses (Indications)

Complicated skin & soft tissue infections (cSSTI)
Complicated intra-abdominal infections (cIAI)
Community-acquired bacterial pneumonia (CABP)
Bacterial infections resistant to other antibiotics

(Not FDA-approved for diabetic foot infections or bacteremia due to higher mortality risk in some studies.)

Storage

Unreconstituted vials: Store at 20–25°C, protect from light.
Reconstituted solution:
- Stable for 6 hours at room temperature or 24 hours refrigerated (2–8°C).
Do not freeze.

Recommendations

Use only when other antibiotics fail (due to increased mortality risk in some infections).
Monitor for superinfections (e.g., C. difficile, fungal infections).
Avoid in pregnancy & breastfeeding (Category D – fetal harm risk).

Important Notes

⚠ Black Box Warning:

Increased mortality risk observed in some infections (especially hospital-acquired pneumonia).
Reserve for situations where alternatives are inadequate.

Side Effects:

Common: Nausea, vomiting, diarrhea.
Serious: Pancreatitis, hepatic dysfunction, hypersensitivity.

Drug Interactions:

Warfarin (increased INR monitoring needed).
Oral contraceptives (reduced efficacy – use backup contraception).

Conclusion

Tiganex (Tigecycline) is a last-resort antibiotic for MDR infections. Use cautiously due to safety concerns and limited spectrum against some pathogens.

Reviews

There are no reviews yet.

Be the first to review “Tiganex Inj”

Medical Disclaimer

Anteka Pharmacy primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on Anteka Pharmacy. Our mission is to support, not replace, the doctor-patient relationship.