XYLISTIN 1MIU

Antibacterial

Description
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XYLISTIN 1 MIU is a sterile, lyophilized powder for intravenous (IV) or intramuscular (IM) administration, containing colistimethate sodium (1 million international units [MIU] per vial). It belongs to the polymyxin class of antibiotics and is specifically used for severe infections caused by multidrug-resistant (MDR) Gram-negative bacteria, including Pseudomonas aeruginosa, Acinetobacter baumannii, and carbapenem-resistant Enterobacteriaceae (CRE).

Composition

Active Ingredient:
- Colistimethate sodium (equivalent to 1 MIU colistin base activity per vial).
Excipients:
- Sodium hydroxide (for pH adjustment).

Mechanism of Action

Bactericidal effect by binding to the lipopolysaccharide (LPS) in the outer membrane of Gram-negative bacteria.
Disrupts cell membrane integrity, causing leakage of cellular contents and bacterial death.
Effective against MDR strains, including:
- Carbapenem-resistant Enterobacteriaceae (CRE)
- ESBL-producing E. coli and Klebsiella
- Pan-resistant Pseudomonas and Acinetobacter

Dosage & Administration

Standard Adult Dose (IV/IM):

Loading Dose: 4.5–6 MIU (divided into 2 doses 12 hours apart).
Maintenance Dose: 1.5–2 MIU every 12 hours (adjusted for renal function).

Pediatric Dose:

2.5–5 MIU/kg/day in 2–4 divided doses (max 9 MIU/day).

Renal Dose Adjustment:

CrCl 30–50 mL/min: 1 MIU every 12 hours.
CrCl 10–30 mL/min: 0.5–1 MIU every 24 hours.
CrCl <10 mL/min or dialysis: 0.5 MIU every 48 hours (post-dialysis).

Administration Guidelines:

IV: Reconstitute with 1 mL sterile water, then dilute in 50 mL NS/D5W; infuse over 30–60 minutes.
IM: Deep injection (may require lidocaine for pain).

Uses (Indications)

✔ Hospital-acquired pneumonia (HAP/VAP) ✔ Bloodstream infections (sepsis) ✔ Complicated urinary tract infections (cUTIs) ✔ Wound infections and burn sepsis ✔ Meningitis (intrathecal use in some cases)

Storage

Unreconstituted powder: Store at 2–8°C (refrigerated); protect from light.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze or shake vigorously.

Recommendations

✔ Monitor renal function (SCr, BUN) before and during therapy. ✔ Assess for neurotoxicity (tingling, dizziness, seizures). ✔ Avoid concurrent nephrotoxic drugs (e.g., vancomycin, NSAIDs). ✔ Not effective against Gram-positive or anaerobic bacteria.

Important Note

Contraindications:

Hypersensitivity to colistin or polymyxins.
Myasthenia gravis (risk of neuromuscular blockade).

Side Effects:

⚠ Nephrotoxicity (↑ SCr, acute kidney injury). ⚠ Neurotoxicity (paresthesia, ataxia, seizures). ⚠ Hypersensitivity reactions (rash, anaphylaxis).

Injection site pain (IM route).

Drug Interactions:

Aminoglycosides/vancomycin: ↑ Nephrotoxicity.
Neuromuscular blockers: ↑ Respiratory depression.

Pregnancy & Lactation:

Category C (use only if benefits outweigh risks).
Breastfeeding: Avoid (unknown excretion in milk).

Presentation

Single-dose vial (1 MIU powder for reconstitution).

Composition

Active Ingredient:
- Colistimethate sodium (equivalent to 1 MIU colistin base activity per vial).
Excipients:
- Sodium hydroxide (for pH adjustment).

Mechanism of Action

Bactericidal effect by binding to the lipopolysaccharide (LPS) in the outer membrane of Gram-negative bacteria.
Disrupts cell membrane integrity, causing leakage of cellular contents and bacterial death.
Effective against MDR strains, including:
- Carbapenem-resistant Enterobacteriaceae (CRE)
- ESBL-producing E. coli and Klebsiella
- Pan-resistant Pseudomonas and Acinetobacter

Dosage & Administration

Standard Adult Dose (IV/IM):

Loading Dose: 4.5–6 MIU (divided into 2 doses 12 hours apart).
Maintenance Dose: 1.5–2 MIU every 12 hours (adjusted for renal function).

Pediatric Dose:

2.5–5 MIU/kg/day in 2–4 divided doses (max 9 MIU/day).

Renal Dose Adjustment:

CrCl 30–50 mL/min: 1 MIU every 12 hours.
CrCl 10–30 mL/min: 0.5–1 MIU every 24 hours.
CrCl <10 mL/min or dialysis: 0.5 MIU every 48 hours (post-dialysis).

Administration Guidelines:

IV: Reconstitute with 1 mL sterile water, then dilute in 50 mL NS/D5W; infuse over 30–60 minutes.
IM: Deep injection (may require lidocaine for pain).

Uses (Indications)

✔ Hospital-acquired pneumonia (HAP/VAP)
✔ Bloodstream infections (sepsis)
✔ Complicated urinary tract infections (cUTIs)
✔ Wound infections and burn sepsis
✔ Meningitis (intrathecal use in some cases)

Storage

Unreconstituted powder: Store at 2–8°C (refrigerated); protect from light.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze or shake vigorously.

Recommendations

✔ Monitor renal function (SCr, BUN) before and during therapy.
✔ Assess for neurotoxicity (tingling, dizziness, seizures).
✔ Avoid concurrent nephrotoxic drugs (e.g., vancomycin, NSAIDs).
✔ Not effective against Gram-positive or anaerobic bacteria.

Important Note

Contraindications:

Hypersensitivity to colistin or polymyxins.
Myasthenia gravis (risk of neuromuscular blockade).

Side Effects:

⚠ Nephrotoxicity (↑ SCr, acute kidney injury).
⚠ Neurotoxicity (paresthesia, ataxia, seizures).
⚠ Hypersensitivity reactions (rash, anaphylaxis).

Injection site pain (IM route).

Drug Interactions:

Aminoglycosides/vancomycin: ↑ Nephrotoxicity.
Neuromuscular blockers: ↑ Respiratory depression.

Pregnancy & Lactation:

Category C (use only if benefits outweigh risks).
Breastfeeding: Avoid (unknown excretion in milk).

Presentation

Single-dose vial (1 MIU powder for reconstitution).

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Composition

Active Ingredient:
- Colistimethate sodium (equivalent to 1 MIU colistin base activity per vial).
Excipients:
- Sodium hydroxide (for pH adjustment).

Mechanism of Action

Bactericidal effect by binding to the lipopolysaccharide (LPS) in the outer membrane of Gram-negative bacteria.
Disrupts cell membrane integrity, causing leakage of cellular contents and bacterial death.
Effective against MDR strains, including:
- Carbapenem-resistant Enterobacteriaceae (CRE)
- ESBL-producing E. coli and Klebsiella
- Pan-resistant Pseudomonas and Acinetobacter

Dosage & Administration

Standard Adult Dose (IV/IM):

Loading Dose: 4.5–6 MIU (divided into 2 doses 12 hours apart).
Maintenance Dose: 1.5–2 MIU every 12 hours (adjusted for renal function).

Pediatric Dose:

2.5–5 MIU/kg/day in 2–4 divided doses (max 9 MIU/day).

Renal Dose Adjustment:

CrCl 30–50 mL/min: 1 MIU every 12 hours.
CrCl 10–30 mL/min: 0.5–1 MIU every 24 hours.
CrCl <10 mL/min or dialysis: 0.5 MIU every 48 hours (post-dialysis).

Administration Guidelines:

IV: Reconstitute with 1 mL sterile water, then dilute in 50 mL NS/D5W; infuse over 30–60 minutes.
IM: Deep injection (may require lidocaine for pain).

Uses (Indications)

✔ Hospital-acquired pneumonia (HAP/VAP)
✔ Bloodstream infections (sepsis)
✔ Complicated urinary tract infections (cUTIs)
✔ Wound infections and burn sepsis
✔ Meningitis (intrathecal use in some cases)

Storage

Unreconstituted powder: Store at 2–8°C (refrigerated); protect from light.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze or shake vigorously.

Recommendations

✔ Monitor renal function (SCr, BUN) before and during therapy.
✔ Assess for neurotoxicity (tingling, dizziness, seizures).
✔ Avoid concurrent nephrotoxic drugs (e.g., vancomycin, NSAIDs).
✔ Not effective against Gram-positive or anaerobic bacteria.

Important Note

Contraindications:

Hypersensitivity to colistin or polymyxins.
Myasthenia gravis (risk of neuromuscular blockade).

Side Effects:

⚠ Nephrotoxicity (↑ SCr, acute kidney injury).
⚠ Neurotoxicity (paresthesia, ataxia, seizures).
⚠ Hypersensitivity reactions (rash, anaphylaxis).

Injection site pain (IM route).

Drug Interactions:

Aminoglycosides/vancomycin: ↑ Nephrotoxicity.
Neuromuscular blockers: ↑ Respiratory depression.

Pregnancy & Lactation:

Category C (use only if benefits outweigh risks).
Breastfeeding: Avoid (unknown excretion in milk).

Presentation

Single-dose vial (1 MIU powder for reconstitution).

Reviews

There are no reviews yet.

Be the first to review “XYLISTIN 1MIU”

Description
Reviews (0)

Composition

Active Ingredient:
- Colistimethate sodium (equivalent to 1 MIU colistin base activity per vial).
Excipients:
- Sodium hydroxide (for pH adjustment).

Mechanism of Action

Bactericidal effect by binding to the lipopolysaccharide (LPS) in the outer membrane of Gram-negative bacteria.
Disrupts cell membrane integrity, causing leakage of cellular contents and bacterial death.
Effective against MDR strains, including:
- Carbapenem-resistant Enterobacteriaceae (CRE)
- ESBL-producing E. coli and Klebsiella
- Pan-resistant Pseudomonas and Acinetobacter

Dosage & Administration

Standard Adult Dose (IV/IM):

Loading Dose: 4.5–6 MIU (divided into 2 doses 12 hours apart).
Maintenance Dose: 1.5–2 MIU every 12 hours (adjusted for renal function).

Pediatric Dose:

2.5–5 MIU/kg/day in 2–4 divided doses (max 9 MIU/day).

Renal Dose Adjustment:

CrCl 30–50 mL/min: 1 MIU every 12 hours.
CrCl 10–30 mL/min: 0.5–1 MIU every 24 hours.
CrCl <10 mL/min or dialysis: 0.5 MIU every 48 hours (post-dialysis).

Administration Guidelines:

IV: Reconstitute with 1 mL sterile water, then dilute in 50 mL NS/D5W; infuse over 30–60 minutes.
IM: Deep injection (may require lidocaine for pain).

Uses (Indications)

✔ Hospital-acquired pneumonia (HAP/VAP)
✔ Bloodstream infections (sepsis)
✔ Complicated urinary tract infections (cUTIs)
✔ Wound infections and burn sepsis
✔ Meningitis (intrathecal use in some cases)

Storage

Unreconstituted powder: Store at 2–8°C (refrigerated); protect from light.
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze or shake vigorously.

Recommendations

✔ Monitor renal function (SCr, BUN) before and during therapy.
✔ Assess for neurotoxicity (tingling, dizziness, seizures).
✔ Avoid concurrent nephrotoxic drugs (e.g., vancomycin, NSAIDs).
✔ Not effective against Gram-positive or anaerobic bacteria.

Important Note

Contraindications:

Hypersensitivity to colistin or polymyxins.
Myasthenia gravis (risk of neuromuscular blockade).

Side Effects:

⚠ Nephrotoxicity (↑ SCr, acute kidney injury).
⚠ Neurotoxicity (paresthesia, ataxia, seizures).
⚠ Hypersensitivity reactions (rash, anaphylaxis).

Injection site pain (IM route).

Drug Interactions:

Aminoglycosides/vancomycin: ↑ Nephrotoxicity.
Neuromuscular blockers: ↑ Respiratory depression.

Pregnancy & Lactation:

Category C (use only if benefits outweigh risks).
Breastfeeding: Avoid (unknown excretion in milk).

Presentation

Single-dose vial (1 MIU powder for reconstitution).

Reviews

There are no reviews yet.

Be the first to review “XYLISTIN 1MIU”

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