Xylistin 4.5MIU

Antibacterial

Description
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XYLISTIN 4.5 MIU is a sterile, lyophilized powder for intravenous (IV) or intramuscular (IM) injection, containing Colistimethate Sodium, a polymyxin antibiotic. It is used for the treatment of severe multidrug-resistant Gram-negative infections, particularly those caused by Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae.

Composition

Active Ingredient:
- Colistimethate Sodium (equivalent to 4.5 million international units [MIU] per vial).
Excipients:
- Sodium hydroxide (for pH adjustment).

Mechanism of Action

Bactericidal action by binding to lipopolysaccharides (LPS) in the outer membrane of Gram-negative bacteria.
Disrupts cell membrane integrity, leading to cell lysis.
Effective against multi-drug resistant (MDR) Gram-negative bacteria, including:
- Pseudomonas aeruginosa
- Acinetobacter baumannii
- Carbapenem-resistant Enterobacteriaceae (CRE)

Dosage & Administration

Adult Dose (IV/IM):

Loading Dose: 9 MIU (divided into 2 doses 12 hours apart).
Maintenance Dose: 4.5 MIU every 12 hours (adjust based on renal function).

Pediatric Dose:

2.5–5 MIU/kg/day in 2–4 divided doses (max 9 MIU/day).

Renal Dose Adjustment:

CrCl 30–50 mL/min: 3 MIU every 12 hours.
CrCl 10–30 mL/min: 2.25 MIU every 12 hours.
CrCl <10 mL/min or dialysis: 1.5 MIU every 24 hours (administer after dialysis).

Administration:

IV: Dilute in 50–100 mL NS/D5W, infuse over 30–60 minutes.
IM: Deep intramuscular injection (painful, use lidocaine if needed).

Uses (Indications)

✔ Severe pneumonia (HAP/VAP) caused by MDR Gram-negative bacteria. ✔ Bloodstream infections (sepsis) due to CRE or Pseudomonas. ✔ Complicated urinary tract infections (cUTIs). ✔ Wound infections & burn sepsis. ✔ Meningitis (intrathecal administration in some cases).

Storage

Unreconstituted powder: Store at 2–8°C (refrigerated).
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze.

Recommendations

✔ Monitor renal function (SCr, BUN) before and during therapy. ✔ Check for neurotoxicity (tingling, dizziness, seizures). ✔ Avoid concurrent use with nephrotoxic drugs (vancomycin, aminoglycosides). ✔ Not effective against Gram-positive bacteria or anaerobes.

Important Note

Contraindications:

Hypersensitivity to colistin or polymyxins.
Myasthenia gravis (risk of neuromuscular blockade).

Side Effects:

⚠ Nephrotoxicity (acute kidney injury – monitor SCr). ⚠ Neurotoxicity (paresthesia, seizures, dizziness). ⚠ Hypersensitivity reactions (rash, anaphylaxis).

Injection site pain (IM route).

Drug Interactions:

Aminoglycosides, vancomycin, NSAIDs ↑ nephrotoxicity risk.
Neuromuscular blockers ↑ respiratory depression risk.

Pregnancy & Lactation:

Category C (use only if benefits outweigh risks).
Breastfeeding: Safety unknown (avoid if possible).

Presentation

Single-dose vial (4.5 MIU powder for reconstitution).

Composition

Active Ingredient:
- Colistimethate Sodium (equivalent to 4.5 million international units [MIU] per vial).
Excipients:
- Sodium hydroxide (for pH adjustment).

Mechanism of Action

Bactericidal action by binding to lipopolysaccharides (LPS) in the outer membrane of Gram-negative bacteria.
Disrupts cell membrane integrity, leading to cell lysis.
Effective against multi-drug resistant (MDR) Gram-negative bacteria, including:
- Pseudomonas aeruginosa
- Acinetobacter baumannii
- Carbapenem-resistant Enterobacteriaceae (CRE)

Dosage & Administration

Adult Dose (IV/IM):

Loading Dose: 9 MIU (divided into 2 doses 12 hours apart).
Maintenance Dose: 4.5 MIU every 12 hours (adjust based on renal function).

Pediatric Dose:

2.5–5 MIU/kg/day in 2–4 divided doses (max 9 MIU/day).

Renal Dose Adjustment:

CrCl 30–50 mL/min: 3 MIU every 12 hours.
CrCl 10–30 mL/min: 2.25 MIU every 12 hours.
CrCl <10 mL/min or dialysis: 1.5 MIU every 24 hours (administer after dialysis).

Administration:

IV: Dilute in 50–100 mL NS/D5W, infuse over 30–60 minutes.
IM: Deep intramuscular injection (painful, use lidocaine if needed).

Uses (Indications)

✔ Severe pneumonia (HAP/VAP) caused by MDR Gram-negative bacteria.
✔ Bloodstream infections (sepsis) due to CRE or Pseudomonas.
✔ Complicated urinary tract infections (cUTIs).
✔ Wound infections & burn sepsis.
✔ Meningitis (intrathecal administration in some cases).

Storage

Unreconstituted powder: Store at 2–8°C (refrigerated).
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze.

Recommendations

✔ Monitor renal function (SCr, BUN) before and during therapy.
✔ Check for neurotoxicity (tingling, dizziness, seizures).
✔ Avoid concurrent use with nephrotoxic drugs (vancomycin, aminoglycosides).
✔ Not effective against Gram-positive bacteria or anaerobes.

Important Note

Contraindications:

Hypersensitivity to colistin or polymyxins.
Myasthenia gravis (risk of neuromuscular blockade).

Side Effects:

⚠ Nephrotoxicity (acute kidney injury – monitor SCr).
⚠ Neurotoxicity (paresthesia, seizures, dizziness).
⚠ Hypersensitivity reactions (rash, anaphylaxis).

Injection site pain (IM route).

Drug Interactions:

Aminoglycosides, vancomycin, NSAIDs ↑ nephrotoxicity risk.
Neuromuscular blockers ↑ respiratory depression risk.

Pregnancy & Lactation:

Category C (use only if benefits outweigh risks).
Breastfeeding: Safety unknown (avoid if possible).

Presentation

Single-dose vial (4.5 MIU powder for reconstitution).

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Composition

Active Ingredient:
- Colistimethate Sodium (equivalent to 4.5 million international units [MIU] per vial).
Excipients:
- Sodium hydroxide (for pH adjustment).

Mechanism of Action

Bactericidal action by binding to lipopolysaccharides (LPS) in the outer membrane of Gram-negative bacteria.
Disrupts cell membrane integrity, leading to cell lysis.
Effective against multi-drug resistant (MDR) Gram-negative bacteria, including:
- Pseudomonas aeruginosa
- Acinetobacter baumannii
- Carbapenem-resistant Enterobacteriaceae (CRE)

Dosage & Administration

Adult Dose (IV/IM):

Loading Dose: 9 MIU (divided into 2 doses 12 hours apart).
Maintenance Dose: 4.5 MIU every 12 hours (adjust based on renal function).

Pediatric Dose:

2.5–5 MIU/kg/day in 2–4 divided doses (max 9 MIU/day).

Renal Dose Adjustment:

CrCl 30–50 mL/min: 3 MIU every 12 hours.
CrCl 10–30 mL/min: 2.25 MIU every 12 hours.
CrCl <10 mL/min or dialysis: 1.5 MIU every 24 hours (administer after dialysis).

Administration:

IV: Dilute in 50–100 mL NS/D5W, infuse over 30–60 minutes.
IM: Deep intramuscular injection (painful, use lidocaine if needed).

Uses (Indications)

✔ Severe pneumonia (HAP/VAP) caused by MDR Gram-negative bacteria.
✔ Bloodstream infections (sepsis) due to CRE or Pseudomonas.
✔ Complicated urinary tract infections (cUTIs).
✔ Wound infections & burn sepsis.
✔ Meningitis (intrathecal administration in some cases).

Storage

Unreconstituted powder: Store at 2–8°C (refrigerated).
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze.

Recommendations

✔ Monitor renal function (SCr, BUN) before and during therapy.
✔ Check for neurotoxicity (tingling, dizziness, seizures).
✔ Avoid concurrent use with nephrotoxic drugs (vancomycin, aminoglycosides).
✔ Not effective against Gram-positive bacteria or anaerobes.

Important Note

Contraindications:

Hypersensitivity to colistin or polymyxins.
Myasthenia gravis (risk of neuromuscular blockade).

Side Effects:

⚠ Nephrotoxicity (acute kidney injury – monitor SCr).
⚠ Neurotoxicity (paresthesia, seizures, dizziness).
⚠ Hypersensitivity reactions (rash, anaphylaxis).

Injection site pain (IM route).

Drug Interactions:

Aminoglycosides, vancomycin, NSAIDs ↑ nephrotoxicity risk.
Neuromuscular blockers ↑ respiratory depression risk.

Pregnancy & Lactation:

Category C (use only if benefits outweigh risks).
Breastfeeding: Safety unknown (avoid if possible).

Presentation

Single-dose vial (4.5 MIU powder for reconstitution).

Reviews

There are no reviews yet.

Be the first to review “Xylistin 4.5MIU ”

Description
Reviews (0)

Composition

Active Ingredient:
- Colistimethate Sodium (equivalent to 4.5 million international units [MIU] per vial).
Excipients:
- Sodium hydroxide (for pH adjustment).

Mechanism of Action

Bactericidal action by binding to lipopolysaccharides (LPS) in the outer membrane of Gram-negative bacteria.
Disrupts cell membrane integrity, leading to cell lysis.
Effective against multi-drug resistant (MDR) Gram-negative bacteria, including:
- Pseudomonas aeruginosa
- Acinetobacter baumannii
- Carbapenem-resistant Enterobacteriaceae (CRE)

Dosage & Administration

Adult Dose (IV/IM):

Loading Dose: 9 MIU (divided into 2 doses 12 hours apart).
Maintenance Dose: 4.5 MIU every 12 hours (adjust based on renal function).

Pediatric Dose:

2.5–5 MIU/kg/day in 2–4 divided doses (max 9 MIU/day).

Renal Dose Adjustment:

CrCl 30–50 mL/min: 3 MIU every 12 hours.
CrCl 10–30 mL/min: 2.25 MIU every 12 hours.
CrCl <10 mL/min or dialysis: 1.5 MIU every 24 hours (administer after dialysis).

Administration:

IV: Dilute in 50–100 mL NS/D5W, infuse over 30–60 minutes.
IM: Deep intramuscular injection (painful, use lidocaine if needed).

Uses (Indications)

✔ Severe pneumonia (HAP/VAP) caused by MDR Gram-negative bacteria.
✔ Bloodstream infections (sepsis) due to CRE or Pseudomonas.
✔ Complicated urinary tract infections (cUTIs).
✔ Wound infections & burn sepsis.
✔ Meningitis (intrathecal administration in some cases).

Storage

Unreconstituted powder: Store at 2–8°C (refrigerated).
Reconstituted solution:
- Stable for 24 hours at 2–8°C (discard unused portions).
- Do not freeze.

Recommendations

✔ Monitor renal function (SCr, BUN) before and during therapy.
✔ Check for neurotoxicity (tingling, dizziness, seizures).
✔ Avoid concurrent use with nephrotoxic drugs (vancomycin, aminoglycosides).
✔ Not effective against Gram-positive bacteria or anaerobes.

Important Note

Contraindications:

Hypersensitivity to colistin or polymyxins.
Myasthenia gravis (risk of neuromuscular blockade).

Side Effects:

⚠ Nephrotoxicity (acute kidney injury – monitor SCr).
⚠ Neurotoxicity (paresthesia, seizures, dizziness).
⚠ Hypersensitivity reactions (rash, anaphylaxis).

Injection site pain (IM route).

Drug Interactions:

Aminoglycosides, vancomycin, NSAIDs ↑ nephrotoxicity risk.
Neuromuscular blockers ↑ respiratory depression risk.

Pregnancy & Lactation:

Category C (use only if benefits outweigh risks).
Breastfeeding: Safety unknown (avoid if possible).

Presentation

Single-dose vial (4.5 MIU powder for reconstitution).

Reviews

There are no reviews yet.

Be the first to review “Xylistin 4.5MIU ”

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