CIDNAVIR

Antiviral

Description
Shipping Options
Customer Reviews

1. Product Description

Brand Name: Cidnavir
Generic Name: Cidofovir
Drug Class: Antiviral (Nucleotide analog)
Manufacturer: (Varies by country; often available as a specialty pharmaceutical product)
Dosage Form: Intravenous (IV) solution (typically 375 mg/vial for reconstitution)

2. Composition

Active Ingredient: Cidofovir (as cidofovir hydrate)
Inactive Ingredients: May include sterile water for injection, sodium hydroxide (for pH adjustment)

3. Therapeutic Uses

FDA/EMA-Approved Indications:

Treatment of cytomegalovirus (CMV) retinitis in AIDS patients (second-line therapy)

Off-Label/Investigational Uses:

Adenovirus infections (in immunocompromised patients)
Herpesvirus infections (e.g., refractory HSV or VZV)

Mechanism of Action:

Inhibits viral DNA polymerase, preventing viral replication.

4. Dosage & Administration

Standard Adult Dose for CMV Retinitis:

Induction: 5 mg/kg IV once weekly for 2 weeks (with probenecid and saline hydration).
Maintenance: 5 mg/kg IV every 2 weeks (with probenecid).

Key Administration Notes: ✔ Must be given with:

Probenecid (to reduce nephrotoxicity)
IV saline hydration (before and after infusion) ✔ Infusion rate: Slow IV over 1 hour. ✔ Dose adjustment required for renal impairment.

5. Contraindications

❌ Severe renal impairment (CrCl ≤ 55 mL/min) ❌ Hypersensitivity to cidofovir or probenecid ❌ Concurrent use with nephrotoxic drugs (e.g., furosemide, aminoglycosides)

6. Side Effects

Common	Serious (Require Immediate Action)
Nephrotoxicity (↑ creatinine)	Severe kidney failure
Neutropenia	Uveitis/eye inflammation
Nausea/vomiting	Metabolic acidosis
Probenecid-related reactions (rash, headache)	Hypotension during infusion

7. Storage & Handling

Unopened vials: Store at 2–8°C (refrigerate).
After reconstitution: Use within 24 hours if refrigerated.
Protect from light.

8. Black Box Warnings (FDA)

⚠ Nephrotoxicity: Can cause permanent kidney damage. ⚠ Must administer with probenecid and hydration. ⚠ Carcinogenic/mutagenic potential (avoid in pregnancy).

9. Drug Interactions

Nephrotoxic drugs (e.g., NSAIDs, vancomycin): ↑ Risk of kidney injury.
Zidovudine: May ↑ toxicity.

10. Patient Counseling Points

✔ Report decreased urine output or eye pain immediately. ✔ Complete probenecid dosing as prescribed. ✔ Avoid pregnancy (teratogenic risk).

Note:

Cidnavir is a high-alert medication used only in hospital/specialty settings.
Confirm local availability and protocols (may differ by country).

1. Product Description

Brand Name: Cidnavir
Generic Name: Cidofovir
Drug Class: Antiviral (Nucleotide analog)
Manufacturer: (Varies by country; often available as a specialty pharmaceutical product)
Dosage Form: Intravenous (IV) solution (typically 375 mg/vial for reconstitution)

2. Composition

Active Ingredient: Cidofovir (as cidofovir hydrate)
Inactive Ingredients: May include sterile water for injection, sodium hydroxide (for pH adjustment)

3. Therapeutic Uses

FDA/EMA-Approved Indications:

Treatment of cytomegalovirus (CMV) retinitis in AIDS patients (second-line therapy)

Off-Label/Investigational Uses:

Adenovirus infections (in immunocompromised patients)
Herpesvirus infections (e.g., refractory HSV or VZV)

Mechanism of Action:

Inhibits viral DNA polymerase, preventing viral replication.

4. Dosage & Administration

Standard Adult Dose for CMV Retinitis:

Induction: 5 mg/kg IV once weekly for 2 weeks (with probenecid and saline hydration).
Maintenance: 5 mg/kg IV every 2 weeks (with probenecid).

Key Administration Notes:
✔ Must be given with:

Probenecid (to reduce nephrotoxicity)
IV saline hydration (before and after infusion)
✔ Infusion rate: Slow IV over 1 hour.
✔ Dose adjustment required for renal impairment.

5. Contraindications

❌ Severe renal impairment (CrCl ≤ 55 mL/min)
❌ Hypersensitivity to cidofovir or probenecid
❌ Concurrent use with nephrotoxic drugs (e.g., furosemide, aminoglycosides)

6. Side Effects

Common	Serious (Require Immediate Action)
Nephrotoxicity (↑ creatinine)	Severe kidney failure
Neutropenia	Uveitis/eye inflammation
Nausea/vomiting	Metabolic acidosis
Probenecid-related reactions (rash, headache)	Hypotension during infusion

7. Storage & Handling

Unopened vials: Store at 2–8°C (refrigerate).
After reconstitution: Use within 24 hours if refrigerated.
Protect from light.

8. Black Box Warnings (FDA)

⚠ Nephrotoxicity: Can cause permanent kidney damage.
⚠ Must administer with probenecid and hydration.
⚠ Carcinogenic/mutagenic potential (avoid in pregnancy).

9. Drug Interactions

Nephrotoxic drugs (e.g., NSAIDs, vancomycin): ↑ Risk of kidney injury.
Zidovudine: May ↑ toxicity.

10. Patient Counseling Points

✔ Report decreased urine output or eye pain immediately.
✔ Complete probenecid dosing as prescribed.
✔ Avoid pregnancy (teratogenic risk).

Note:

Cidnavir is a high-alert medication used only in hospital/specialty settings.
Confirm local availability and protocols (may differ by country).

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

1. Product Description

Brand Name: Cidnavir
Generic Name: Cidofovir
Drug Class: Antiviral (Nucleotide analog)
Manufacturer: (Varies by country; often available as a specialty pharmaceutical product)
Dosage Form: Intravenous (IV) solution (typically 375 mg/vial for reconstitution)

2. Composition

Active Ingredient: Cidofovir (as cidofovir hydrate)
Inactive Ingredients: May include sterile water for injection, sodium hydroxide (for pH adjustment)

3. Therapeutic Uses

FDA/EMA-Approved Indications:

Treatment of cytomegalovirus (CMV) retinitis in AIDS patients (second-line therapy)

Off-Label/Investigational Uses:

Adenovirus infections (in immunocompromised patients)
Herpesvirus infections (e.g., refractory HSV or VZV)

Mechanism of Action:

Inhibits viral DNA polymerase, preventing viral replication.

4. Dosage & Administration

Standard Adult Dose for CMV Retinitis:

Induction: 5 mg/kg IV once weekly for 2 weeks (with probenecid and saline hydration).
Maintenance: 5 mg/kg IV every 2 weeks (with probenecid).

Key Administration Notes:
✔ Must be given with:

Probenecid (to reduce nephrotoxicity)
IV saline hydration (before and after infusion)
✔ Infusion rate: Slow IV over 1 hour.
✔ Dose adjustment required for renal impairment.

5. Contraindications

❌ Severe renal impairment (CrCl ≤ 55 mL/min)
❌ Hypersensitivity to cidofovir or probenecid
❌ Concurrent use with nephrotoxic drugs (e.g., furosemide, aminoglycosides)

6. Side Effects

Common	Serious (Require Immediate Action)
Nephrotoxicity (↑ creatinine)	Severe kidney failure
Neutropenia	Uveitis/eye inflammation
Nausea/vomiting	Metabolic acidosis
Probenecid-related reactions (rash, headache)	Hypotension during infusion

7. Storage & Handling

Unopened vials: Store at 2–8°C (refrigerate).
After reconstitution: Use within 24 hours if refrigerated.
Protect from light.

8. Black Box Warnings (FDA)

⚠ Nephrotoxicity: Can cause permanent kidney damage.
⚠ Must administer with probenecid and hydration.
⚠ Carcinogenic/mutagenic potential (avoid in pregnancy).

9. Drug Interactions

Nephrotoxic drugs (e.g., NSAIDs, vancomycin): ↑ Risk of kidney injury.
Zidovudine: May ↑ toxicity.

10. Patient Counseling Points

✔ Report decreased urine output or eye pain immediately.
✔ Complete probenecid dosing as prescribed.
✔ Avoid pregnancy (teratogenic risk).

Note:

Cidnavir is a high-alert medication used only in hospital/specialty settings.
Confirm local availability and protocols (may differ by country).

Reviews

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Be the first to review “CIDNAVIR”

Description
Reviews (0)

1. Product Description

Brand Name: Cidnavir
Generic Name: Cidofovir
Drug Class: Antiviral (Nucleotide analog)
Manufacturer: (Varies by country; often available as a specialty pharmaceutical product)
Dosage Form: Intravenous (IV) solution (typically 375 mg/vial for reconstitution)

2. Composition

Active Ingredient: Cidofovir (as cidofovir hydrate)
Inactive Ingredients: May include sterile water for injection, sodium hydroxide (for pH adjustment)

3. Therapeutic Uses

FDA/EMA-Approved Indications:

Treatment of cytomegalovirus (CMV) retinitis in AIDS patients (second-line therapy)

Off-Label/Investigational Uses:

Adenovirus infections (in immunocompromised patients)
Herpesvirus infections (e.g., refractory HSV or VZV)

Mechanism of Action:

Inhibits viral DNA polymerase, preventing viral replication.

4. Dosage & Administration

Standard Adult Dose for CMV Retinitis:

Induction: 5 mg/kg IV once weekly for 2 weeks (with probenecid and saline hydration).
Maintenance: 5 mg/kg IV every 2 weeks (with probenecid).

Key Administration Notes:
✔ Must be given with:

Probenecid (to reduce nephrotoxicity)
IV saline hydration (before and after infusion)
✔ Infusion rate: Slow IV over 1 hour.
✔ Dose adjustment required for renal impairment.

5. Contraindications

❌ Severe renal impairment (CrCl ≤ 55 mL/min)
❌ Hypersensitivity to cidofovir or probenecid
❌ Concurrent use with nephrotoxic drugs (e.g., furosemide, aminoglycosides)

6. Side Effects

Common	Serious (Require Immediate Action)
Nephrotoxicity (↑ creatinine)	Severe kidney failure
Neutropenia	Uveitis/eye inflammation
Nausea/vomiting	Metabolic acidosis
Probenecid-related reactions (rash, headache)	Hypotension during infusion

7. Storage & Handling

Unopened vials: Store at 2–8°C (refrigerate).
After reconstitution: Use within 24 hours if refrigerated.
Protect from light.

8. Black Box Warnings (FDA)

⚠ Nephrotoxicity: Can cause permanent kidney damage.
⚠ Must administer with probenecid and hydration.
⚠ Carcinogenic/mutagenic potential (avoid in pregnancy).

9. Drug Interactions

Nephrotoxic drugs (e.g., NSAIDs, vancomycin): ↑ Risk of kidney injury.
Zidovudine: May ↑ toxicity.

10. Patient Counseling Points

✔ Report decreased urine output or eye pain immediately.
✔ Complete probenecid dosing as prescribed.
✔ Avoid pregnancy (teratogenic risk).

Note:

Cidnavir is a high-alert medication used only in hospital/specialty settings.
Confirm local availability and protocols (may differ by country).

Reviews

There are no reviews yet.

Be the first to review “CIDNAVIR”

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