Introduction
Famtrex is a brand name for famciclovir, an antiviral medication used to treat infections caused by herpes viruses, including:
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Herpes simplex virus (HSV-1 & HSV-2) – Genital herpes, cold sores
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Varicella-zoster virus (VZV) – Shingles (herpes zoster)
Famciclovir is a prodrug of penciclovir, meaning it converts into its active form in the body, providing long-lasting antiviral effects.
Description
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Generic Name:Â Famciclovir
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Brand Names:Â Famtrex (India), Famvir (global brand)
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Dosage Forms:Â Tablets (250 mg, 500 mg)
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Manufacturer:Â Lupin (Famtrex brand)
Uses
Famtrex is prescribed for:
✔ Genital herpes (treatment & suppression)
✔ Cold sores (oral herpes)
✔ Shingles (herpes zoster)
✔ Recurrent herpes in immunocompromised patients (e.g., HIV)
Mechanism of Action
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Famciclovir is converted into penciclovir in the body.
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Penciclovir inhibits viral DNA polymerase, stopping the herpes virus from replicating.
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Reduces outbreak severity, speeds healing, and lowers transmission risk.
Side Effects
Common side effects:
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Headache
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Nausea, diarrhea
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Fatigue, dizziness
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Mild skin rash
Serious side effects (rare):
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Kidney dysfunction (in high doses or dehydrated patients)
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Neurological effects (confusion, hallucinations – rare)
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Hematologic abnormalities (low platelets – very rare)
Storage
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Store at room temperature (15-30°C).
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Keep away from moisture and light.
Precautions & Warnings
âš Â Kidney impairment:Â Dose adjustment required (lower doses for renal patients).
âš Â Hydration:Â Drink plenty of water to prevent kidney issues.
âš Â Pregnancy & breastfeeding:Â Use only if benefits outweigh risks.
âš Â Immunocompromised patients:Â Higher risk of side effects; monitor closely.
âš Â Drug interactions:
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Probenecid (may increase famciclovir levels)
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Nephrotoxic drugs (e.g., NSAIDs, aminoglycosides – may worsen kidney risk)
Conclusion
Famtrex (famciclovir) is an effective antiviral for herpes infections, offering convenient dosing and strong viral suppression. It is well-tolerated but requires caution in kidney patients.
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