Introduction:
Microvir 250 is an antiviral medication containing Famciclovir (250mg), a prodrug of penciclovir. It is used to treat infections caused by herpesviruses, including genital herpes, cold sores (herpes labialis), and shingles (herpes zoster).
Description:
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Generic Name:Â Famciclovir
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Brand Name:Â Microvir 250
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Drug Class:Â Antiviral (Nucleoside analogue)
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Mechanism of Action:
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Converts into penciclovir in the body, which inhibits viral DNA polymerase, preventing herpesvirus replication.
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Therapeutic Uses:
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Genital Herpes (Herpes Simplex Virus – HSV-2):
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Treatment of recurrent episodes
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Suppressive therapy (prevents frequent outbreaks)
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Cold Sores (Herpes Labialis – HSV-1):
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Reduces healing time and symptom severity
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Herpes Zoster (Shingles):
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Less commonly used at this dose (500mg preferred)
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Dosage:
Condition | Dosage | Duration |
---|---|---|
Recurrent Genital Herpes | 125mg twice daily | 5 days |
Suppressive Therapy (Genital Herpes) | 250mg twice daily | Up to 1 year |
Cold Sores (Herpes Labialis) | 1500mg single dose (or 750mg x 2 doses) | 1 day |
Renal Impairment | Dose adjustment needed (reduce frequency) | As prescribed |
Side Effects:
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Common:
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Headache, nausea, dizziness, fatigue
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Less Common:
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Rash, itching, abdominal pain, diarrhea
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Rare but Serious:
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Allergic reactions, liver enzyme changes, confusion (especially in elderly)
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Importance:
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Reduces viral shedding and transmission risk (especially in genital herpes).
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Shortens outbreak duration and severity.
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Used for long-term suppression in recurrent herpes.
Storage:
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Store below 30°C, in a dry place away from sunlight.
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Keep tightly closed in original packaging.
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Keep out of reach of children.
Conclusion:
Microvir 250 (Famciclovir) is effective for genital herpes suppression and cold sore treatment. Proper dosing ensures optimal results while minimizing side effects.
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