Introduction
Valcivir is a brand name for valacyclovir, an antiviral medication used to treat infections caused by herpes viruses, including:
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Herpes simplex virus (HSV-1 & HSV-2) – Cold sores, genital herpes
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Varicella-zoster virus (VZV) – Chickenpox, shingles (herpes zoster)
It is a prodrug of acyclovir, meaning it converts into acyclovir in the body, providing better absorption and longer-lasting effects.
Description
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Generic Name:Â Valacyclovir hydrochloride
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Brand Names:Â Valcivir (India), Valtrex (global brand)
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Dosage Forms:Â Tablets (typically 500 mg, 1000 mg)
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Manufacturer:Â Cipla (Valcivir brand)
Use
Valcivir is prescribed for:
✔ Genital herpes (treatment & suppression)
✔ Cold sores (oral herpes)
✔ Shingles (herpes zoster)
✔ Chickenpox (in some cases)
✔ Prevention of CMV (cytomegalovirus) in immunocompromised patients
Mechanism of Action
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Valacyclovir is converted into acyclovir in the body.
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Acyclovir inhibits viral DNA polymerase, preventing the herpes virus from replicating.
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This reduces the severity and duration of outbreaks and helps prevent new ones.
Side Effects
Common side effects:
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Headache
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Nausea, stomach pain
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Dizziness, fatigue
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Mild skin rash
Serious side effects (rare):
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Kidney dysfunction (in high doses or dehydrated patients)
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Neurological effects (confusion, hallucinations, seizures – rare)
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Thrombotic thrombocytopenic purpura (TTP)/hemolytic uremic syndrome (HUS) – Very rare but serious
Storage
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Store at room temperature (15-30°C).
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Keep away from moisture and light.
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Keep out of reach of children.
Precautions & Warnings
âš Â Kidney impairment:Â Dose adjustment needed (consult doctor).
âš Â Hydration:Â Drink plenty of water to prevent kidney issues.
âš Â Pregnancy & breastfeeding:Â Generally considered safe but consult a doctor.
âš Â HIV/AIDS & immunocompromised patients:Â Higher risk of side effects; monitor closely.
âš Â Drug interactions:
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Probenecid (increases acyclovir levels)
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Nephrotoxic drugs (e.g., NSAIDs, aminoglycosides – may increase kidney risk)
Conclusion
Valcivir (valacyclovir) is a highly effective antiviral for herpes infections, offering better absorption than acyclovir. It helps manage outbreaks and reduce transmission but requires caution in kidney patients.
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