Etacept (Etanercept) 25mg Injection is a medication used to treat various conditions, including:
- Rheumatoid arthritis (RA)
- Psoriatic arthritis (PsA)
- Juvenile idiopathic arthritis (JIA)
- Plaque psoriasis
- Enthesitis-related arthritis (ERA)
- Ankylosing spondylitis (AS)
Composition: Each injection of Etacept contains 25mg of Etanercept (an active pharmaceutical ingredient), which is a recombinant human tumor necrosis factor (TNF) receptor fusion protein.
Mechanism of Action: Etanercept works by binding to TNF-alpha, a protein that plays a key role in inflammation and immune response. By binding to TNF-alpha, Etanercept inhibits its activity and reduces the inflammation and immune response associated with the conditions it is used to treat.
Dosage: The recommended dose of Etacept varies depending on the condition being treated. For rheumatoid arthritis and psoriatic arthritis, the usual dose is 25mg injected subcutaneously twice a week. For juvenile idiopathic arthritis, the usual dose is 25mg injected subcutaneously once a week. For plaque psoriasis, the usual dose is 25mg injected subcutaneously twice a week for 3 months, followed by 25mg injected subcutaneously every other week.
Side Effects: Common side effects of Etacept include:
- Injection site reactions
- Headache
- Fatigue
- Muscle or joint pain
- Nausea
- Diarrhea
- Rash
Rare but serious side effects include:
- Increased risk of infections, including serious infections such as tuberculosis and sepsis
- Increased risk of lymphoma and other types of cancer
- Increased risk of demyelinating diseases, such as multiple sclerosis and Guillain-Barré syndrome
- Increased risk of autoimmune disorders, such as lupus-like syndrome and vitiligo
Recommendation: Etacept is recommended for patients with rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, plaque psoriasis, enthesitis-related arthritis, or ankylosing spondylitis who have not responded to other treatments. Patients with a history of hypersensitivity reactions to Etanercept or other TNF-alpha inhibitors should not receive Etacept.
Important Note:
- Etacept should be used under the guidance of a healthcare provider with experience in the treatment of the condition being treated.
- Patients with a history of liver disease, kidney disease, or other medical conditions that may affect their ability to respond to treatment should be closely monitored while taking Etacept.
- Etacept may interact with other medications, such as immunosuppressants and certain antibiotics. Patients should inform their healthcare provider of all medications they are taking before starting Etacept therapy.
- Patients should be advised to report any symptoms of hypersensitivity reactions, such as rash, itching, swelling, or difficulty breathing.
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