Febustat (Febuxostat) 40 mg Tablet is a medication used to treat gout and hyperuricemia (high levels of uric acid in the blood). It is a xanthine oxidase inhibitor, which reduces the production of uric acid in the body.
Composition: Each tablet contains 40 mg of Febuxostat (an active pharmaceutical ingredient).
Mechanism of Action: Febuxostat works by inhibiting the enzyme xanthine oxidase, which is responsible for converting purines into uric acid. By reducing the production of uric acid, Febustat helps to lower serum uric acid levels and prevent the formation of uric acid crystals in the joints, which can cause gout attacks.
Dosage: The recommended dose of Febustat is 40 mg once daily. It may be taken with or without food. The dosage may be adjusted based on individual patient response and serum uric acid levels.
Uses: Febustat is used to treat:
- Gout
- Hyperuricemia (high levels of uric acid in the blood)
- Prevention of recurrent gout attacks
Side Effects: Common side effects of Febustat include:
- Nausea
- Diarrhea
- Abdominal pain
- Headache
- Fatigue
- Muscle pain
- Skin rash
- Swelling
Rare but serious side effects include:
- Liver damage
- Blood disorders
- Severe allergic reactions
Recommendation: Febustat is recommended for patients with a history of gout or hyperuricemia who have not responded to other treatments. It is also recommended for patients who are unable to tolerate other treatments for gout. Patients with liver disease or kidney disease should be closely monitored while taking Febustat.
Important Note:
- Febustat is not recommended for patients with severe kidney disease or end-stage renal disease.
- Patients with liver disease should be monitored regularly for liver function test results.
- Febustat may increase the risk of liver damage in patients with pre-existing liver disease.
- Patients taking Febustat should be advised to report any symptoms of liver damage, such as yellowing of the skin and eyes, dark urine, or pale stools.
- Febustat may interact with other medications, such as warfarin, methotrexate, and sulfonamides. Patients should inform their healthcare provider of all medications they are taking before starting Febustat therapy.
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