Imutrex 10

Imutrex (Methotrexate) 10mg Tablets are a medication used to treat various conditions, including:

• Rheumatoid arthritis (a type of arthritis that causes inflammation and joint pain)
• Psoriasis (a skin condition that causes red, scaly patches)
• Polyarticular juvenile idiopathic arthritis (a type of arthritis that affects children and causes inflammation and joint pain)
• Moderate to severe Crohn’s disease and ulcerative colitis (conditions that cause inflammation in the digestive tract)

Composition: Each 10mg tablet of Imutrex contains 10mg of Methotrexate (an active pharmaceutical ingredient), which is an antimetabolite medication.

Mechanism of Action: Methotrexate works by:

• Inhibiting the production of folic acid, which is necessary for cell growth and division
• Inhibiting the activity of enzymes that are involved in the synthesis of nucleic acids and proteins
• Reducing the production of inflammatory chemicals, such as cytokines and chemokines

Dosage: The recommended dose of Imutrex varies depending on the condition being treated. For rheumatoid arthritis, the recommended dose is 7.5-15mg once weekly. For psoriasis, the recommended dose is 10-20mg once weekly. For polyarticular juvenile idiopathic arthritis, the recommended dose is 10-15mg once weekly. For Crohn’s disease and ulcerative colitis, the recommended dose is 25-30mg once daily.

Side Effects: Common side effects of Imutrex include:

• Nausea
• Vomiting
• Diarrhea
• Stomach pain
• Headache
• Fatigue
• Dizziness
• Skin rash

Rare but serious side effects include:

• Severe allergic reactions, including anaphylaxis and Stevens-Johnson syndrome
• Bone marrow suppression, which can lead to anemia, neutropenia, or thrombocytopenia
• Liver damage, which can lead to liver failure or liver transplant
• Pulmonary toxicity, which can lead to lung damage or lung failure

Recommendation: Imutrex is recommended for patients with various conditions who have not responded to other treatments or who have had unacceptable side effects. Patients with kidney disease or other medical conditions that may affect their ability to respond to treatment should be closely monitored while taking Imutrex.

Important Note:

• Imutrex should be used under the guidance of a healthcare provider with experience in the treatment of the condition being treated.
• Patients should be advised to report any symptoms of hypersensitivity reactions, such as rash, itching, swelling, or difficulty breathing.
• Imutrex may interact with other medications, such as warfarin and certain antibiotics. Patients should inform their healthcare provider of all medications they are taking before starting Imutrex therapy.
• Patients with a history of kidney disease or other medical conditions that may affect their ability to respond to treatment should be closely monitored while taking Imutrex.

Special Precautions:

• Patients with a history of kidney disease should be closely monitored while taking Imutrex.
• Patients with a history of liver disease should be closely monitored while taking Imutrex.
• Patients with a history of bone marrow suppression should be closely monitored while taking Imutrex.
• Pregnant or breastfeeding women should consult their healthcare provider before taking Imutrex.