Infimab

Infimab is a prescription medication used to treat several conditions, including:

• Rheumatoid Arthritis (RA)
• Psoriatic Arthritis (PsA)
• Ankylosing Spondylitis (AS)
• Crohn’s Disease
• Ulcerative Colitis

Composition: Infimab is a chimeric monoclonal antibody that targets and neutralizes tumor necrosis factor-alpha (TNF-alpha), a protein that contributes to inflammation and joint damage in these conditions.

Indications: Infimab is indicated for the treatment of:

• Rheumatoid Arthritis (RA) in adults who have had an inadequate response to other treatments
• Psoriatic Arthritis (PsA) in adults who have had an inadequate response to other treatments
• Ankylosing Spondylitis (AS) in adults who have had an inadequate response to other treatments
• Crohn’s Disease in adults who have had an inadequate response to other treatments
• Ulcerative Colitis in adults who have had an inadequate response to other treatments

Mechanism of Action: Infimab works by binding to TNF-alpha and preventing it from interacting with its receptors, thereby reducing inflammation and joint damage.

Dosage and Administration: Infimab is administered via intravenous infusion every 8 weeks, with the first dose given as a 0.5 mg/kg infusion and subsequent doses given as a 0.5-1 mg/kg infusion.

Side Effects: Common side effects of Infimab include:

• Headache
• Fatigue
• Nasopharyngitis
• Upper respiratory tract infections
• Allergic reactions
• Increased risk of serious infections, including opportunistic infections such as tuberculosis

Precautions: Infimab is not recommended for individuals with:

• Active tuberculosis or a history of latent tuberculosis that has not been properly treated
• Active or chronic infections, including bacterial, fungal, or viral infections
• Weakened immune system
• History of lymphoma or other malignancies
• Pregnancy or breastfeeding

Contraindications:

• Active tuberculosis or a history of latent tuberculosis that has not been properly treated
• Active or chronic infections, including bacterial, fungal, or viral infections
• Weakened immune system

Special Precautions:

• Individuals with a history of opportunistic infections, including tuberculosis, should be monitored closely for signs of infection.
• Individuals with a history of lymphoma or other malignancies should be monitored closely for signs of recurrence.
• Infimab should not be used in combination with other immunosuppressive medications without close monitoring.

Important Note: Infimab is only available by prescription and should only be used under the guidance of a healthcare provider. It is important to follow the dosage and administration instructions carefully and to report any side effects or concerns to your healthcare provider.