Pdlast Apremilast is a prescription medication that is used to treat active psoriatic arthritis (PsA) in adults. It is also used to treat moderate to severe plaque psoriasis (PsO) in adults who are candidates for phototherapy or systemic therapy. Apremilast works by blocking the action of a specific enzyme called phosphodiesterase 4 (PDE4), which helps to reduce inflammation and joint pain.
Composition: Each tablet of Pdlast Apremilast contains:
- 30mg of apremilast
Indications: Pdlast Apremilast is indicated for the treatment of:
- Active psoriatic arthritis (PsA) in adults
- Moderate to severe plaque psoriasis (PsO) in adults who are candidates for phototherapy or systemic therapy
Mechanism of Action: Apremilast works by blocking the action of phosphodiesterase 4 (PDE4), which is an enzyme that breaks down cyclic adenosine monophosphate (cAMP). By blocking PDE4, apremilast increases the levels of cAMP in the body, which helps to reduce inflammation and joint pain.
Dosage and Administration: The recommended dosage of Pdlast Apremilast is 30mg twice daily, taken orally. The tablets should be swallowed whole and not crushed or chewed.
Side Effects: Common side effects of Pdlast Apremilast include:
- Headache
- Nausea
- Diarrhea
- Abdominal pain
- Fatigue
- Muscle pain
- Insomnia
- Anxiety
- Depression
Precautions: Pdlast Apremilast should not be used by individuals with:
- Hypersensitivity to apremilast or any of its components
- Known cardiac conduction abnormalities or arrhythmias
- Known severe liver disease or hepatic impairment
Contraindications:
- Pregnancy or breastfeeding
- Children under the age of 18
Special Precautions:
- Individuals with a history of depression or suicidal thoughts should be monitored closely while taking Pdlast Apremilast.
- Individuals with a history of kidney disease should be monitored closely while taking Pdlast Apremilast.
- Individuals with a history of liver disease should be monitored closely while taking Pdlast Apremilast.
Important Note: Pdlast Apremilast is a prescription medication and should only be used under the guidance of a healthcare provider. It is important to follow the recommended dosage and administration instructions carefully and to report any side effects or concerns to your healthcare provider.
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