Mitomycin 40 mg

Mitomycin 40 mg is a branded version of Mitomycin, a cancer medication used to treat various types of cancer, including stomach cancer, breast cancer, and lung cancer.

Composition:

Each 40 mg vial of Mitomycin 40 mg contains mitomycin, a mitomycin C derivative, and sodium chloride.

Mechanism of Action:

Mitomycin works by inhibiting the growth of cancer cells by:

1. Interfering with the replication of DNA
2. Damaging the DNA of cancer cells
3. Inhibiting the activity of enzymes that promote cell growth

Use:

Mitomycin 40 mg is indicated for the treatment of:

1. Stomach cancer (gastric adenocarcinoma)
2. Breast cancer (node-positive or node-negative)
3. Lung cancer (non-small cell lung cancer)

Dosage:

The recommended dosage of Mitomycin 40 mg varies depending on the indication and patient characteristics:

1. Stomach cancer: 20-30 mg/m² IV every 6-8 weeks for up to 6 courses.
2. Breast cancer: 20-30 mg/m² IV every 6-8 weeks for up to 6 courses.
3. Lung cancer: 10-20 mg/m² IV every 6-8 weeks for up to 6 courses.

Side Effects:

Common side effects of Mitomycin 40 mg include:

1. Nausea and vomiting
2. Diarrhea
3. Fatigue
4. Hair loss
5. Redness and swelling at the injection site

Serious side effects can include:

1. Bone marrow suppression (reduced blood cell count)
2. Increased risk of infection
3. Cardiac problems (e.g., heart failure, arrhythmias)
4. Gastrointestinal perforation (hole in the stomach or intestine)

Recommendation:

Mitomycin 40 mg should be administered under the guidance of a healthcare professional, and patients should be closely monitored for signs of bone marrow suppression, infection, and cardiac problems.

Important Note:

• Patients with pre-existing cardiac problems, kidney disease, or liver disease should be carefully monitored while receiving Mitomycin 40 mg.
• Patients with a history of gastrointestinal disorders (e.g., peptic ulcer disease) should be monitored for signs of perforation.
• Women of childbearing potential should use effective contraception while receiving Mitomycin 40 mg.
• Pregnant or breastfeeding women should not receive Mitomycin 40 mg.